Article(id=1292126475134727000, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.02.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1762963200000, receivedDateStr=2025-11-13, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996558221, onlineDateStr=2026-08-06, pubDate=1769529600000, pubDateStr=2026-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996558221, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996558221, creator=13701087609, updateTime=1785996558221, updator=13701087609, issue=Issue{id=1292126409196064779, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='2', pageStart='151', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1769529600000', pubDateStr='2026-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996542500, creator='13701087609', updateTime=1786014671444, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292202447569707674, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292202447569707675, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=158, endPage=163, ext={EN=ArticleExt(id=1292126475549963097, articleId=1292126475134727000, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Efficacy of ceftazidime/avibactam combined with polymyxin in the treatment of carbapenem-resistant Gram-negative bacterial pulmonary infections, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the efficacy of ceftazidime/avibactam (CAZ/AVI) combined with polymyxin in the treatment of carbapenem-resistant Gram-negative bacteria (CRO) pulmonary infections.
Methods A total of 80 patients with CRO pulmonary infections admitted to our hospital from December 2019 to December 2024 were selected and divided into a control group (n=37) and a CAZ/AVI group (n=43) based on treatment methods. The control group received colistimethate sodium combined with meropenem, while the CAZ/AVI group received CAZ/AVI combined with colistimethate sodium. The clinical efficacy, bacterial clearance rate, and prognosis were compared between the two groups. Based on treatment efficacy, patients were classified into an effective group and an ineffective group, and logistic analysis was performed to identify factors influencing treatment outcomes in CRO pulmonary infections.
Results The clinical efficacy and bacterial clearance rate in the CAZ/AVI group were higher than those in the control group (P<0.05); there was no statistically significant difference in 28-day mortality between the two groups (P>0.05). The levels of WBC, CRP, PCT, TNF-α, IL-6, and IL-10 in the CAZ/AVI group were lower than those in the control group (P<0.05). In the effective group, age, APACHE Ⅱ score, SOFA score, and the proportion of patients receiving continuous renal replacement therapy (CRRT) were lower than those in the ineffective group, while treatment duration and the proportion receiving CAZ/AVI combined with polymyxin were higher (P<0.05). Logistic analysis indicated that APACHE Ⅱ score, SOFA score, CRRT, treatment duration, and CAZ/AVI combined with polymyxin were influencing factors for treatment outcomes in CRO pulmonary infections (P<0.05).
Conclusion CAZ/AVI combined with polymyxin shows significant efficacy in the treatment of CRO pulmonary infections.
, authors=Rong LIU, Jiang-nan ZHENG, Hong-ju BAO, Wei WANG, Zheng FU, Jin-yu SU, authorsList=Rong LIU, Jiang-nan ZHENG, Hong-ju BAO, Wei WANG, Zheng FU, Jin-yu SU, authorCompany=null, correspAuthors=Jin-yu SU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126476363658074, articleId=1292126475134727000, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=头孢他啶/阿维巴坦联合多黏菌素对耐碳青霉烯革兰阴性菌肺部感染的疗效分析, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究头孢他啶/阿维巴坦（CAZ/AVI）联合多黏菌素对耐碳青霉烯革兰阴性菌（CRO）肺部感染的疗效。
方法 选取2019年12月到2024年12月本院接收的80例CRO肺部感染患者，按治疗方法分为对照组（n=37）和CAZ/AVI组（n=43）。对照组给予多黏菌素E甲磺酸钠联合美罗培南治疗。CAZ/AVI组给予CAZ/AVI联合多黏菌素E甲磺酸钠治疗，比较两组的临床疗效、细菌清除率及预后。根据治疗疗效分为有效组和无效组，并采用Logistic分析CRO肺部感染治疗疗效的影响因素。
结果 CAZ/AVI组的临床疗效、细菌清除率高于对照组（P<0.05）；两组的28 d死亡率比较，差异无统计学意义（P>0.05）。CAZ/AVI组的WBC、CRP、PCT、TNF-α、IL -6、IL -10低于对照组（P<0.05）。有效组的年龄、APACHE Ⅱ评分、SOFA评分、接受连续性肾脏替代治疗（CRRT）比例低于无效组，用药疗程、接受CAZ/AVI联合多黏菌素治疗比例高于无效组（P<0.05）；Logistic分析表明，APACHE Ⅱ评分、SOFA评分、接受CRRT、用药疗程、CAZ/AVI联合多黏菌素治疗是CRO肺部感染治疗疗效的影响因素（P<0.05）。
结论 CAZ/AVI联合多黏菌素对CRO肺部感染的疗效较为显著。
, authors=刘蓉, 郑江南, 包红菊, 王伟, 傅正, 苏晋豫, authorsList=刘蓉, 郑江南, 包红菊, 王伟, 傅正, 苏晋豫, authorCompany=null, correspAuthors=苏晋豫, authorNote=
刘蓉（1989-），女，主治医师，主要从事慢性气道炎症性疾病及常见呼吸危重症疾病的研究
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=cVTE6kW8lXHP2OrCsas9Og==, magXml=wZOsz75xoUGn9DkRgtKiQg==, pdfUrl=null, pdf=iBeMnIG+lI5FQbHiAh4lfg==, pdfFileSize=1660654, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=H4loN/arek1ubUmoF5dwYA==, mapNumber=null, fund=null)}, authors=[Author(id=1292126478213346143, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292126478297232225, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, authorId=1292126478213346143, language=EN, stringName=Rong LIU, firstName=Rong, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Respiratory and Critical Care Medicine Department, Suzhou Ninth People’s Hospital, Suzhou 215200, Jiangxi Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126478376924002, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, authorId=1292126478213346143, language=CN, stringName=刘蓉, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=苏州市第九人民医院 呼吸与危重症医学科 江苏 苏州 215200, bio={"content":"
刘蓉（1989-），女，主治医师，主要从事慢性气道炎症性疾病及常见呼吸危重症疾病的研究
"}, bioImg=null, bioContent=
刘蓉（1989-），女，主治医师，主要从事慢性气道炎症性疾病及常见呼吸危重症疾病的研究
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126478133654363, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, xref=null, ext=[AuthorCompanyExt(id=1292126478142042972, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Respiratory and Critical Care Medicine Department, Suzhou Ninth People’s Hospital, Suzhou 215200, Jiangxi Province, China), AuthorCompanyExt(id=1292126478150431581, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=苏州市第九人民医院 呼吸与危重症医学科 江苏 苏州 215200)])]), Author(id=1292126478439838564, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292126478519530342, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, authorId=1292126478439838564, language=EN, stringName=Jiang-nan ZHENG, firstName=Jiang-nan, middleName=null, lastName=ZHENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Respiratory and Critical Care Medicine Department, Suzhou Ninth People’s Hospital, Suzhou 215200, Jiangxi Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126478578250599, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, authorId=1292126478439838564, language=CN, stringName=郑江南, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=苏州市第九人民医院 呼吸与危重症医学科 江苏 苏州 215200, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126478133654363, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, xref=null, ext=[AuthorCompanyExt(id=1292126478142042972, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Respiratory and Critical Care Medicine Department, Suzhou Ninth People’s Hospital, Suzhou 215200, Jiangxi Province, China), AuthorCompanyExt(id=1292126478150431581, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=苏州市第九人民医院 呼吸与危重症医学科 江苏 苏州 215200)])]), Author(id=1292126478653748073, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292126478758605675, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, authorId=1292126478653748073, language=EN, stringName=Hong-ju BAO, firstName=Hong-ju, middleName=null, lastName=BAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Respiratory and Critical Care Medicine Department, Suzhou Ninth People’s Hospital, Suzhou 215200, Jiangxi Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126478901212012, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, authorId=1292126478653748073, language=CN, stringName=包红菊, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=苏州市第九人民医院 呼吸与危重症医学科 江苏 苏州 215200, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126478133654363, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, xref=null, ext=[AuthorCompanyExt(id=1292126478142042972, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Respiratory and Critical Care Medicine Department, Suzhou Ninth People’s Hospital, Suzhou 215200, Jiangxi Province, China), AuthorCompanyExt(id=1292126478150431581, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=苏州市第九人民医院 呼吸与危重症医学科 江苏 苏州 215200)])]), Author(id=1292126478993486702, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292126479148675952, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, authorId=1292126478993486702, language=EN, stringName=Wei WANG, firstName=Wei, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Respiratory and Critical Care Medicine Department, Suzhou Ninth People’s Hospital, Suzhou 215200, Jiangxi Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126479199007601, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, authorId=1292126478993486702, language=CN, stringName=王伟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=苏州市第九人民医院 呼吸与危重症医学科 江苏 苏州 215200, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126478133654363, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, xref=null, ext=[AuthorCompanyExt(id=1292126478142042972, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Respiratory and Critical Care Medicine Department, Suzhou Ninth People’s Hospital, Suzhou 215200, Jiangxi Province, China), AuthorCompanyExt(id=1292126478150431581, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=苏州市第九人民医院 呼吸与危重症医学科 江苏 苏州 215200)])]), Author(id=1292126479245144947, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292126479312253813, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, authorId=1292126479245144947, language=EN, stringName=Zheng FU, firstName=Zheng, middleName=null, lastName=FU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Respiratory and Critical Care Medicine Department, Suzhou Ninth People’s Hospital, Suzhou 215200, Jiangxi Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126479366779766, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, authorId=1292126479245144947, language=CN, stringName=傅正, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=苏州市第九人民医院 呼吸与危重症医学科 江苏 苏州 215200, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126478133654363, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, xref=null, ext=[AuthorCompanyExt(id=1292126478142042972, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Respiratory and Critical Care Medicine Department, Suzhou Ninth People’s Hospital, Suzhou 215200, Jiangxi Province, China), AuthorCompanyExt(id=1292126478150431581, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=苏州市第九人民医院 呼吸与危重症医学科 江苏 苏州 215200)])]), Author(id=1292126479438082936, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=15962545331@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1292126479517774714, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, authorId=1292126479438082936, language=EN, stringName=Jin-yu SU, firstName=Jin-yu, middleName=null, lastName=SU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Respiratory and Critical Care Medicine Department, Suzhou Ninth People’s Hospital, Suzhou 215200, Jiangxi Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126479580689275, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, authorId=1292126479438082936, language=CN, stringName=苏晋豫, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=苏州市第九人民医院 呼吸与危重症医学科 江苏 苏州 215200, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126478133654363, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, xref=null, ext=[AuthorCompanyExt(id=1292126478142042972, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Respiratory and Critical Care Medicine Department, Suzhou Ninth People’s Hospital, Suzhou 215200, Jiangxi Province, China), AuthorCompanyExt(id=1292126478150431581, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=苏州市第九人民医院 呼吸与危重症医学科 江苏 苏州 215200)])])], keywords=[Keyword(id=1292126479719101308, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, language=EN, orderNo=1, keyword=ceftazidime/avibactam), Keyword(id=1292126479794598782, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, language=EN, orderNo=2, keyword=carbapenem-resistant Gram-negative bacteria), Keyword(id=1292126479886873471, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, language=EN, orderNo=3, keyword=pulmonary infection), Keyword(id=1292126479966565248, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, language=EN, orderNo=4, keyword=prognosis), Keyword(id=1292126480025285505, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, language=CN, orderNo=1, keyword=头孢他啶/阿维巴坦), Keyword(id=1292126480088200066, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, language=CN, orderNo=2, keyword=耐碳青霉烯革兰阴性菌), Keyword(id=1292126480151114627, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, language=CN, orderNo=3, keyword=肺部感染), Keyword(id=1292126480209834884, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, language=CN, orderNo=4, keyword=预后)], refs=null, funds=[Fund(id=1292126480306303877, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, awardId=BK20211019, language=CN, fundingSource=江苏省自然科学基金资助项目(BK20211019), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1292126478133654363, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, xref=null, ext=[AuthorCompanyExt(id=1292126478142042972, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Respiratory and Critical Care Medicine Department, Suzhou Ninth People’s Hospital, Suzhou 215200, Jiangxi Province, China), AuthorCompanyExt(id=1292126478150431581, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126475134727000, companyId=1292126478133654363, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=苏州市第九人民医院 呼吸与危重症医学科 江苏 苏州 215200)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1788948995538, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509895005466898, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995591, updatedTime=1788948995591, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1304509895047409939, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995601, updatedTime=1788948995601, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2026.02.002, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2026.02.002, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2026.02.002, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2026.02.002, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1769529600000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
180
73
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
