Article(id=1292126407983915196, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126377440989952, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.01.022, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1763481600000, receivedDateStr=2025-11-19, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996542210, onlineDateStr=2026-08-06, pubDate=1768579200000, pubDateStr=2026-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996542210, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996542210, creator=13701087609, updateTime=1785996542210, updator=13701087609, issue=Issue{id=1292126377440989952, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='1', pageStart='1', pageEnd='147', issueExtLink='null', onlineDate='null', pubDate='1768579200000', pubDateStr='2026-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996534929, creator='13701087609', updateTime=1786014708731, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292202603945947673, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126377440989952, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292202603950141978, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126377440989952, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=137, endPage=141, ext={EN=ArticleExt(id=1292126408197824701, articleId=1292126407983915196, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of pharmacological mechanism of organosulfur compounds from garlic on ischemia-reperfusion injury of urinary system, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Ischemia-reperfusion injury (I/R) is a common pathological process in clinical practice, referring to the phenomenon where the degree of tissue or organ damage intensifies when blood flow is restored after ischemia. In the urinary system, renal I/R is a key factor in inducing acute kidney injury, and its mechanism is closely related to the burst of reactive oxygen species (ROS) and systemic inflammatory responses after ischemia, which can also cause chain damage to multiple organs such as the testis through the blood circulation. Garlic, as a traditional food and medicine, its derived organic polysulfides (such as allicin, S-allyl cysteine, etc.) have been proven to have pharmacological activities such as anti-oxidative stress, anti-apoptosis and anti-inflammation. This article systematically reviews the protective effects and molecular mechanisms of garlic-derived organic polysulfides in urinary system I/R injury. At the level of oxidative stress, it restores the oxidative balance by regulating the activities of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) and ROS-generating enzymes; at the anti-apoptotic level, it inhibits excessive apoptosis of renal tubular epithelial cells by targeting the B-cell lymphoma 2 protein (Bcl-2)/ Bcl-2 associated X protein (Bax) family and cysteine aspartate-specific protease (Caspase) cascade pathways; at the anti-inflammatory level, it regulates the balance of interleukin (IL)-4/IL-10 and IL-6/ tumor necrosis factor-alpha (TNF-α), and controls the nuclear factor-kappa B (NF-κB) pathway and macrophage polarization, its protective effects have multi-target and multi-organ characteristics. This article aims to provide new ideas for the prevention and treatment of urinary system I/R-related injuries, and at the same time looks forward to further exploring the cross-regulation mechanism of oxidative stress-apoptosis-inflammation in the future, with the expectation of promoting it to become a potential clinical treatment option.

, authors=Ning HAN, Xu-tao SUN, Jia-xu CHEN, Cai-yun MAO, Yun-jia SONG, authorsList=Ning HAN, Xu-tao SUN, Jia-xu CHEN, Cai-yun MAO, Yun-jia SONG, authorCompany=null, correspAuthors=Yun-jia SONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126408436900030, articleId=1292126407983915196, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=大蒜来源的有机多硫化物对泌尿系统缺血再灌注损伤的药理机制研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

缺血再灌注损伤（I/R）是临床常见病理过程，指组织器官缺血后恢复血流供应时，损伤程度反而加剧的病理现象。在泌尿系统中，肾I/R是诱发急性肾损伤的关键因素，其发生机制与缺血后大量活性氧（ROS）爆发、全身性炎症反应等密切相关，且可以通过血液循环引发睾丸等多器官连锁损伤。大蒜作为药食同源的传统食材，其衍生的有机多硫化物（如大蒜素、S-烯丙基半胱氨酸等）已被证实具有抗氧化应激、抗细胞凋亡及抗炎等药理活性，其保护效应具有多靶点、多器官特征。本文系统综述了大蒜衍生有机多硫化物在泌尿系统I/R损伤中的保护作用及分子机制。在氧化应激层面，通过调控超氧化物歧化酶（SOD）、过氧化氢酶（CAT）等抗氧化酶及ROS生成酶活性恢复氧化平衡；在抗凋亡层面，靶向B细胞淋巴瘤-2相关蛋白（Bcl-2）/Bcl-2相关X蛋白（Bax）家族、半胱天冬酶（Caspase）级联通路抑制肾小管上皮细胞过度凋亡；在抗炎层面，调节白细胞介素（IL）-4/IL-10与IL-6/肿瘤坏死因子α（TNF-α）平衡，调控核因子-κB（NF-κB）通路及巨噬细胞极化。本文旨在为泌尿系统I/R相关损伤的防治提供新思路，同时展望未来更深入探索氧化应激-凋亡-炎症的交叉调控机制，以期推动其成为临床潜在的治疗方案。

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韩宁（2002-），女，硕士研究生，主要从事心血管疾病方面的研究

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韩宁（2002-），女，硕士研究生，主要从事心血管疾病方面的研究

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