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To evaluate the antifungal activity of minocycline (MIN), this study followed the methodological framework of a scoping review, systematically searched Chinese and English databases, and included 36 studies for inductive analysis. Results showed that MIN has a narrow direct antifungal spectrum, mainly acting on some Candida albicans strains. However, when combined with antifungal agents, it exerted a significant synergistic effect against various drug-resistant fungi. Its direct mechanisms included inhibiting hyphal transition and biofilm formation, as well as inducing oxidative stress and apoptosis. The synergistic mechanisms involved disrupting calcium homeostasis, destroying biofilm structure, increasing cell membrane permeability, interfering with amino acid metabolism and depending on the ergosterol biosynthesis gene 3 (ERG3). Both in vitro and in vivo studies consistently confirmed its efficacy, though it was affected by factors such as biofilm maturity, combination regimens and strain differences. MIN had clear antifungal potential, supported by substantial evidence on its mechanisms and preclinical data, but clinical translation remained inadequate. Future efforts should focus on conducting high-level preclinical validation and proof-of-concept clinical trials to clarify its efficacy, safety and optimal treatment regimens in humans, thereby promoting its clinical application.

, authors=Chen-can CHI, Fang ZHENG, authorsList=Chen-can CHI, Fang ZHENG, authorCompany=null, correspAuthors=Fang ZHENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126434064097634, articleId=1292126431568486752, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=米诺环素抗真菌活性的范围研究进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

为评估米诺环素（MIN）的抗真菌活性，本研究遵循范围综述方法学框架，系统检索中英文数据库，共纳入36项研究进行归纳分析。结果显示，MIN直接抗真菌谱较窄，主要作用于部分白色念珠菌，但与抗真菌药联用可以对多种耐药真菌产生显著协同效应。其直接机制包括抑制菌丝转换与生物膜形成、诱导氧化应激与细胞凋亡；协同机制则涉及扰乱钙稳态、破坏生物膜结构、增加细胞膜通透性、干扰氨基酸代谢及麦角甾醇生物合成基因3（ERG3）依赖性。体内外研究一致证实其疗效，但受生物膜成熟度、联合方案及菌株差异等因素影响。MIN具有明确的抗真菌潜力，机制与临床前证据较充分，但临床转化不足。未来需重点开展高级别临床前验证与概念临床试验，明确其人体疗效、安全性及最佳治疗方案，以推动其临床应用。

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池晨灿（1999-），女，硕士研究生，主要从事儿童呼吸系统疾病的相关研究

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池晨灿（1999-），女，硕士研究生，主要从事儿童呼吸系统疾病的相关研究

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