Article(id=1292126400178312119, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126377440989952, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.01.016, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758470400000, receivedDateStr=2025-09-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996540350, onlineDateStr=2026-08-06, pubDate=1768579200000, pubDateStr=2026-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996540350, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996540350, creator=13701087609, updateTime=1785996540350, updator=13701087609, issue=Issue{id=1292126377440989952, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='1', pageStart='1', pageEnd='147', issueExtLink='null', onlineDate='null', pubDate='1768579200000', pubDateStr='2026-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996534929, creator='13701087609', updateTime=1786014708731, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292202603945947673, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126377440989952, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292202603950141978, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126377440989952, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=100, endPage=106, ext={EN=ArticleExt(id=1292126400375444408, articleId=1292126400178312119, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research of propofol alleviating intestinal ischemia-reperfusion injury in rats, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the potential mechanism of propofol in improving intestinal ischemia-reperfusion injury (IIRI).
Methods SD rats were randomly divided into sham group, model group (the superior mesenteric artery was clamped for 45 min and reperfusion for 2 h), experimental-L group (injection of 30 mg·kg-1 propofol before ischemia), experimental-M group (injection of 45 mg·kg-1 propofol before ischemia), experimental-H group (injection of 60 mg·kg-1 propofol before ischemia); after reperfusion, the rats were killed and intestinal tissues were taken for use. Hematoxylin-eosin (HE) staining was used to observe the intestinal histopathological changes, Western blot assay was used to detect the expression of Bcl-2 antagonist killer(BAK), Bcl-2 associated X(BAX) and other proteins, and real-time quantitative polymerase chain reaction (RT-qPCR) assay was used to detect the expression of cytoplasmic mitochondrial DNA (mtDNA). The enzyme activity and enzyme-linked immunosorbent assay was used to detect the expression of adenosine triphosphate (ATP) and interleukin (IL)-1β in intestinal tissue.
Results The pathological injury scores (Chiu’s methods) in sham group, model group, experimental-L group, experimental-M group and experimental-H group were (0±0), (4.20±0.60), (3.00±0.45), (2.20±0.40) and (1.00±0.77) points, respectively; the relative expression levels of BAK protein were 0.24±0.03, 0.66±0.08, 0.56±0.08, 0.40±0.05 and 0.34±0.03, respectively; the relative expression levels of BAX protein were 0.35±0.03, 0.79±0.11, 0.62±0.03, 0.51±0.05 and 0.40±0.04, respectively; the relative expression levels of NOD-like receptor pyrin domain-containing protein 3 (NLRP3) protein were 0.32±0.03, 1.05±0.12, 0.81±0.11, 0.64±0.08 and 0.49±0.08, respectively; the relative expression levels of Cyclic guanosine monophosphate adenosine synthase (cGAS) protein were 0.23±0.02, 0.97±0.10, 0.78±0.08, 0.63±0.07 and 0.45±0.07, respectively; the relative expression levels of the NADH dehydrogenase subunit (ND)1 mRNA were 1.00±0.08, 2.23±0.29, 1.79±0.13, 1.59±0.11 and 1.34±0.09, respectively; the levels of ATP production were 1.00±0.14, 0.47±0.03, 0.65±0.07, 0.80±0.06 and 0.81±0.12, respectively. Compared model group with the sham group and compared experimental-L, M, H group with model group, the differences of above indicators were all statistically significant (all P<0.05).
Conclusion Propofol can dose-dependently improve intestinal injury in IIRI rats and this protective effect was accompanied by downregulation of BAK/BAX protein expression, reduction of mtDNA release, and decreased activity of the downstream cGAS/NLRP3 inflammatory pathway.
, authors=Yu-hua GAO, Ke MAO, Peng-sen LIU, Si-long DU, authorsList=Yu-hua GAO, Ke MAO, Peng-sen LIU, Si-long DU, authorCompany=null, correspAuthors=Yu-hua GAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126400606131129, articleId=1292126400178312119, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=丙泊酚减轻大鼠肠缺血再灌注损伤的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨丙泊酚改善肠缺血再灌注损伤（IIRI）的潜在作用机制。
方法 将SD大鼠随机分为假手术组、模型组（夹闭肠系膜上动脉45 min后再灌注2 h）、低剂量实验组（缺血前注射30 mg·kg-1丙泊酚）、中剂量实验组（缺血前注射45 mg·kg-1丙泊酚）和高剂量实验组（缺血前注射60 mg·kg-1丙泊酚），再灌注结束后处死大鼠，取肠组织备用。用苏木精-伊红（HE）染色法观察肠组织病理学改变，用蛋白质印迹法检测Bcl-2拮抗杀伤蛋白（BAK）、Bcl-2相关X蛋白（BAX）等蛋白表达，用实时定量聚合酶链反应（RT-qPCR）实验法检测胞质线粒体DNA（mtDNA）表达，用酶活性及酶联免疫吸附测定试剂盒法检测肠组织腺苷三磷酸（ATP）和白细胞介素（IL）-1β表达。
结果 假手术组、模型组、低剂量实验组、中剂量实验组和高剂量实验组大鼠病理损伤评分（Chiu’s法）分别为（0±0）、（4.20±0.60）、（3.00±0.45）、（2.20±0.40）和（1.00±0.77）分；BAK蛋白相对表达水平分别为0.24±0.03、0.66±0.08、0.56±0.08、0.40±0.05和0.34±0.03；BAX蛋白相对表达水平分别为0.35±0.03、0.79±0.11、0.62±0.03、0.51±0.05和0.40±0.04；NOD样受体热蛋白结构域相关蛋白3（NLRP3）蛋白相对表达水平分别为0.32±0.03、1.05±0.12、0.81±0.11、0.64±0.08和0.49±0.08；环鸟苷单磷酸腺苷合成酶（cGAS）蛋白相对表达水平分别为0.23±0.02、0.97±0.10、0.78±0.08、0.63±0.07和0.45±0.07；NADH脱氢酶亚基（ND）1 mRNA相对表达水平分别为1.00±0.08、2.23±0.29、1.79±0.13、1.59±0.11和1.34±0.09；ATP生成相对水平分别为1.00±0.14、0.47±0.03、0.65±0.07、0.80±0.06和0.81±0.12；上述指标模型组与假手术组比较，低、高剂量实验组分别与模型组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 丙泊酚可以剂量依赖性地减轻肠缺血再灌注损伤。该保护作用伴随着BAK/BAX蛋白表达下调、胞质mtDNA释放减少以及下游cGAS/NLRP3炎症通路活性的降低。
, authors=高誉华, 毛轲, 刘鹏森, 杜思龙, authorsList=高誉华, 毛轲, 刘鹏森, 杜思龙, authorCompany=null, correspAuthors=高誉华, authorNote=
高誉华（1987-），女，主治医师，主要从事麻醉与疼痛方面的工作和研究
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=ajyTM25mWb6owtAe0lff5w==, magXml=zgjSjOLOowiURiA2XnO/1Q==, pdfUrl=null, pdf=EijvUZKIHRhL0ew2mOCTng==, pdfFileSize=1601596, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=evQa0qBV6L1GBtcPzoUZAw==, mapNumber=null, fund=null)}, authors=[Author(id=1292126402334184382, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=18736037837@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1292126402409681856, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, authorId=1292126402334184382, language=EN, stringName=Yu-hua GAO, firstName=Yu-hua, middleName=null, lastName=GAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Anesthesiology, Henan Hospital of Traditional Chinese Medicine/Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126402472596417, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, authorId=1292126402334184382, language=CN, stringName=高誉华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=河南省中医院/河南中医药大学 第二附属医院 麻醉科，河南 郑州 450002, bio={"content":"
高誉华（1987-），女，主治医师，主要从事麻醉与疼痛方面的工作和研究
"}, bioImg=null, bioContent=
高誉华（1987-），女，主治医师，主要从事麻醉与疼痛方面的工作和研究
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126402250298298, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, xref=null, ext=[AuthorCompanyExt(id=1292126402258686907, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, companyId=1292126402250298298, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology, Henan Hospital of Traditional Chinese Medicine/Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan Province, China), AuthorCompanyExt(id=1292126402267075516, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, companyId=1292126402250298298, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=河南省中医院/河南中医药大学 第二附属医院 麻醉科，河南 郑州 450002)])]), Author(id=1292126402535510979, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292126402606814149, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, authorId=1292126402535510979, language=EN, stringName=Ke MAO, firstName=Ke, middleName=null, lastName=MAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Anesthesiology, Henan Hospital of Traditional Chinese Medicine/Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126402678117318, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, authorId=1292126402535510979, language=CN, stringName=毛轲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=河南省中医院/河南中医药大学 第二附属医院 麻醉科，河南 郑州 450002, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126402250298298, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, xref=null, ext=[AuthorCompanyExt(id=1292126402258686907, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, companyId=1292126402250298298, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology, Henan Hospital of Traditional Chinese Medicine/Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan Province, China), AuthorCompanyExt(id=1292126402267075516, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, companyId=1292126402250298298, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=河南省中医院/河南中医药大学 第二附属医院 麻醉科，河南 郑州 450002)])]), Author(id=1292126402753614792, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292126402829112266, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, authorId=1292126402753614792, language=EN, stringName=Peng-sen LIU, firstName=Peng-sen, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Anesthesiology, Henan Hospital of Traditional Chinese Medicine/Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126402904609739, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, authorId=1292126402753614792, language=CN, stringName=刘鹏森, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=河南省中医院/河南中医药大学 第二附属医院 麻醉科，河南 郑州 450002, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126402250298298, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, xref=null, ext=[AuthorCompanyExt(id=1292126402258686907, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, companyId=1292126402250298298, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology, Henan Hospital of Traditional Chinese Medicine/Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan Province, China), AuthorCompanyExt(id=1292126402267075516, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, companyId=1292126402250298298, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=河南省中医院/河南中医药大学 第二附属医院 麻醉科，河南 郑州 450002)])]), Author(id=1292126402967524301, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292126403059798991, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, authorId=1292126402967524301, language=EN, stringName=Si-long DU, firstName=Si-long, middleName=null, lastName=DU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Anesthesiology, Henan Hospital of Traditional Chinese Medicine/Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126403139490768, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, authorId=1292126402967524301, language=CN, stringName=杜思龙, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=河南省中医院/河南中医药大学 第二附属医院 麻醉科，河南 郑州 450002, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126402250298298, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, xref=null, ext=[AuthorCompanyExt(id=1292126402258686907, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, companyId=1292126402250298298, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology, Henan Hospital of Traditional Chinese Medicine/Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan Province, China), AuthorCompanyExt(id=1292126402267075516, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, companyId=1292126402250298298, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=河南省中医院/河南中医药大学 第二附属医院 麻醉科，河南 郑州 450002)])])], keywords=[Keyword(id=1292126403240154066, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, language=EN, orderNo=1, keyword=propofol), Keyword(id=1292126403307262931, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, language=EN, orderNo=2, keyword=intestinal ischemia-reperfusion injury), Keyword(id=1292126403399537620, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, language=EN, orderNo=3, keyword=Bcl-2 antagonist killer/Bcl-2 associated X protein), Keyword(id=1292126403496006613, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, language=EN, orderNo=4, keyword=mitochondrial DNA), Keyword(id=1292126403571504086, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, language=EN, orderNo=5, keyword=oxidative stress), Keyword(id=1292126403651195863, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, language=CN, orderNo=1, keyword=丙泊酚), Keyword(id=1292126403726693336, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, language=CN, orderNo=2, keyword=肠缺血再灌注损伤), Keyword(id=1292126403806385113, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, language=CN, orderNo=3, keyword=Bcl-2拮抗杀伤蛋白/Bcl-2相关X蛋白), Keyword(id=1292126403886076890, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, language=CN, orderNo=4, keyword=线粒体DNA), Keyword(id=1292126403953185755, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, language=CN, orderNo=5, keyword=氧化应激), Keyword(id=1292126404011906012, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, language=CN, orderNo=6, keyword=炎症反应)], refs=null, funds=null, companyList=[AuthorCompany(id=1292126402250298298, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, xref=null, ext=[AuthorCompanyExt(id=1292126402258686907, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, companyId=1292126402250298298, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology, Henan Hospital of Traditional Chinese Medicine/Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan Province, China), AuthorCompanyExt(id=1292126402267075516, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126400178312119, companyId=1292126402250298298, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=河南省中医院/河南中医药大学 第二附属医院 麻醉科，河南 郑州 450002)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1788948995538, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509895005466898, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995591, updatedTime=1788948995591, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1304509895047409939, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995601, updatedTime=1788948995601, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2026.01.016, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2026.01.016, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2026.01.016, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2026.01.016, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1768579200000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
152
50
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
