Article(id=1292126425411248433, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126377440989952, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.01.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1746720000000, receivedDateStr=2025-05-09, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996546365, onlineDateStr=2026-08-06, pubDate=1768579200000, pubDateStr=2026-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996546365, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996546365, creator=13701087609, updateTime=1785996546365, updator=13701087609, issue=Issue{id=1292126377440989952, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='1', pageStart='1', pageEnd='147', issueExtLink='null', onlineDate='null', pubDate='1768579200000', pubDateStr='2026-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996534929, creator='13701087609', updateTime=1786014708731, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292202603945947673, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126377440989952, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292202603950141978, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126377440989952, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=53, endPage=58, ext={EN=ArticleExt(id=1292126427114135858, articleId=1292126425411248433, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research of Effects of paeonol on autophagy and NLRP3 inflammasome in renal tubular epithelial cells induced by albumin, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the regulatory effects of paeonol on autophagy and the NOD-like receptor protein 3 (NLRP3) inflammasome in human renal proximal tubular epithelial cells (HK-2) induced by human serum albumin (HSA).
Methods HK-2 cells were cultured in vitro and randomly assigned to control group, model group, as well as low-, medium- and high-dose experimental groups. Cells in the control group were cultured under normal conditions; those in the model group were treated with 20 mg·mL-1 HSA for 24 h; and cells in the low-, medium- and high-dose experimental groups were administered 25, 50 and 100 μmol·L-1 paeonol, respectively, for 24 h on the basis of the model group intervention. Enzyme-linked immunosorbent assay (ELISA) was performed to determine the concentrations of kidney injury molecule 1 (KIM-1), monocyte chemoattractant protein 1 (MCP-1), interleukin 1β (IL-1β) and caspase-1 in the cell supernatant. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the mRNA expression levels of KIM-1 and MCP-1. Western blotting was applied to measure the protein expression levels of NLRP3, apoptosis-associated speck-like protein containing a CARD (ASC), interleukin-1β (IL-1β), microtubule-associated protein 1 light chain 3 (LC3), sequestosome 1(p62), Beclin-1, PTEN-induced kinase 1 (PINK1) and Parkin.
Results The concentrations of KIM-1 in the cell supernatant of the control group, model group, and low-, medium- and high-dose experimental groups were (8.65±0.53), (17.33±2.04), (10.76±1.41), (8.48±0.47) and (8.47±0.24) pg·mL-1, respectively; the contents of MCP-1 were (531.38±15.64), (2 198.55±148.21), (1 966.29±53.52), (1 605.49±234.68) and (937.33±36.96) pg·mL-1, respectively; the secretion levels of IL-1β were (71.66±2.29), (109.92±4.41), (91.68±4.75), (80.66±4.00) and (62.38±3.24) pg·mL-1, respectively; the contents of caspase-1 were (66.57±10.52), (210.50±17.50), (201.88±7.22), (195.42±13.95) and (129.81±13.20) pg·mL-1, respectively; the relative expression levels of KIM-1 mRNA in each group were 1.05±0.05, 2.38±0.45, 1.58±0.20, 1.44±0.08 and 1.38±0.22, respectively; while those of MCP-1 were 1.04±0.04, 1.53±0.08, 1.32±0.16, 1.16±0.16 and 0.62±0.13, respectively; the relative expression levels of NLRP3 protein were 0.89±0.08, 1.13±0.07, 1.00±0.07, 0.84±0.12 and 0.55±0.16, respectively; those of ASC were 0.23±0.03, 0.87±0.19, 0.81±0.16, 0.78±0.08 and 0.46±0.05, respectively; those of IL-1β were 0.49±0.12, 1.46±0.29, 1.10±0.26, 0.71±0.06 and 0.53±0.13, respectively; the LC3Ⅱ/Ⅰ ratios were 1.08±0.04, 0.90±0.06, 1.00±0.02 and 1.05±0.04, respectively; the expression levels of p62 protein were 0.38±0.06, 1.23±0.11, 1.05±0.20 and 0.62±0.19, respectively; those of Beclin-1 were 0.82±0.07, 0.59±0.06, 0.90±0.07 and 0.93±0.09, respectively; those of PINK1 were 1.10±0.03, 0.68±0.07, 0.78±0.11 and 1.03±0.08, respectively; those of Parkin were 0.64±0.06, 0.46±0.05, 0.58±0.08 and 0.79±0.12, respectively. Compared with the control group, all the above indicators in the model group exhibited statistically significant differences (P<0.05, P<0.01, P<0.001). Moreover, the indicators in the high-dose experimental group showed statistically significant differences compared with the model group (P<0.05, P<0.01, P<0.001).
Conclusion Paeonol may alleviate albumin-induced renal tubular injury by promoting mitophagy and inhibiting the activation of the NLRP3 inflammasome.
, authors=Yong-xi HAO
1, Wei LIANG
2, Le SHI
1, Zi-yi QIN
1, Tao LIANG
1, authorsList=Yong-xi HAO, Wei LIANG, Le SHI, Zi-yi QIN, Tao LIANG, authorCompany=null, correspAuthors=Tao LIANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126427516789043, articleId=1292126425411248433, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=丹皮酚对白蛋白诱导的肾小管上皮细胞自噬和NLRP3炎症小体影响的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察丹皮酚对白蛋白（HSA）诱导的肾小管上皮细胞（HK-2）自噬和NOD样受体蛋白3（NLRP3）炎症小体的调控作用。
方法 体外培养HK-2细胞并随机分为对照组、模型组和低、中、高剂量实验组。对照组细胞正常培养；模型组用20 mg·mL-1 HSA干预24 h；低、中、高剂量实验组在模型组的基础上分别加入25、50和100 μmol·L-1丹皮酚处理24 h。酶联免疫吸附实验法检测上清液肾损伤因子1（KIM-1）、单核细胞趋化蛋白-1（MCP-1）、白介素-1β（IL-1β）和胱天蛋白酶-1（caspase-1）的含量，用实时荧光定量聚合酶链反应法检测KIM-1和MCP-1基因表达，用蛋白质印迹法检测含吡喃结构域的NLRP3、含CARD结构域的凋亡相关斑点样蛋白（ASC）、IL-1β、微管相关蛋白1轻链3（LC3）、泛素结合蛋白p62（p62）、自噬效应蛋白Beclin 1（Beclin-1）、PTEN诱导激酶1（PINK1）和Parkin蛋白的表达。
结果 对照组、模型组和低、中、高剂量组细胞上清中KIM-1浓度分别为（8.65±0.53）、（17.33±2.04）、（10.76±1.41）、（8.48±0.47）和（8.47±0.24）pg·mL-1，MCP-1含量为（531.38±15.64）、（2 198.55±148.21）、（1 966.29±53.52）、（1 605.49±234.68）和（937.33±36.96）pg·mL-1，IL-1β分泌水平为（71.66±2.29）、（109.92±4.41）、（91.68±4.75）、（80.66±4.00）和（62.38±3.24）pg·mL-1，caspase-1含量为（66.57±10.52）、（210.50±17.50）、（201.88±7.22）、（195.42±13.95）和（129.81±13.20）pg·mL-1，KIM-1 mRNA基因相对表达水平分别为1.05±0.05、2.38±0.45、1.58±0.20、1.44±0.08和1.38±0.22，MCP-1 mRNA相对表达水平分别为1.04±0.04、1.53±0.08、1.32±0.16、1.16±0.16和0.62±0.13，NLRP3蛋白相对表达水平为0.89±0.08、1.13±0.07、1.00±0.07、0.84±0.12和0.55±0.16，ASC蛋白相对表达水平分别为0.23±0.03、0.87±0.19、0.81±0.16、0.78±0.08和0.46±0.05，IL-1β蛋白相对表达水平分别为0.49±0.12、1.46±0.29、1.10±0.26、0.71±0.06和0.53±0.13，微管相关蛋白1轻链3-2（LC3Ⅱ）/LC3Ⅰ蛋白相对表达水平分别为1.08±0.04、0.90±0.06、1.00±0.02和1.05±0.04，p62蛋白相对表达水平分别为0.38±0.06、1.23±0.11、1.05±0.20和0.62±0.19，Beclin-1蛋白相对表达水平分别为0.82±0.07、0.59±0.06、0.90±0.07和0.93±0.09，PINK1蛋白相对表达水平分别为1.10±0.03、0.68±0.07、0.78±0.11和1.03±0.08，Parkin蛋白相对表达水平为0.64±0.06、0.46±0.05、0.58±0.08和0.79±0.12。模型组的上述指标与对照组比较，在统计学上差异均有统计学意义（P<0.05，P<0.01，P<0.001），高剂量实验组的上述指标与模型组比较，在统计学上差异均有统计学意义（P<0.05，P<0.01，P<0.001）。
结论 丹皮酚可能通过促进线粒体自噬，抑制NLRP3炎症小体，缓解白蛋白导致的肾小管损伤。
, authors=郝永熙
1, 梁卫
2, 时乐
1, 秦子怡
1, 梁涛
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郝永熙（2000-），女，硕士研究生，主要从事抗炎免疫药理方面的研究
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