Article(id=1291707000950387453, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.24.017, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1764172800000, receivedDateStr=2025-11-27, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896547782, onlineDateStr=2026-08-05, pubDate=1766851200000, pubDateStr=2025-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896547782, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896547782, creator=13701087609, updateTime=1785896547782, updator=13701087609, issue=Issue{id=1291706966187991876, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='24', pageStart='3451', pageEnd='3600', issueExtLink='null', onlineDate='null', pubDate='1766851200000', pubDateStr='2025-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896539494, creator='13701087609', updateTime=1785998798662, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292135872292479273, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292135872296673578, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3555, endPage=3561, ext={EN=ArticleExt(id=1291707001202045694, articleId=1291707000950387453, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of mechanisms of action of polygonum cuspidatum and its active components against nonalcoholic steatohepatitis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder characterized by excessive hepatic lipid accumulation resulting from multiple etiological factors. In recent years, changes in lifestyle have contributed to a rising incidence of NAFLD, making it a significant public health concern. Traditional Chinese medicine (TCM), with its multi-component, multi-pathway, and multi-target characteristics, has demonstrated unique advantages and research value in the prevention and treatment of NAFLD. Polygonum cuspidatum is a representative herbal medicine in this context and has been confirmed to possess various pharmacological activities, including anti-inflammatory, antioxidant, and hepatoprotective effects. However, its specific active components and mechanisms of action remain incompletely elucidated. Therefore, this article systematically reviews Chinese and English literature on Polygonum cuspidatum and its active components in the treatment of NAFLD. The results indicate that the core active components of Polygonum cuspidatum against NAFLD include resveratrol, polydatin, emodin, among others. The mechanisms involve multiple pathways, such as the regulation of lipid metabolism, improvement of glucose metabolism and insulin resistance, anti-inflammatory effects, antioxidant stress response, and modulation of gut microbiota. This review aims to provide insights and references for further mechanistic research and clinical application of Polygonum cuspidatum.

, authors=Xiao-li MA¹, Cai-xia ZHOU¹, Hai-ming DONG¹, Zhao-yang WU¹, Jian-xin YANG², authorsList=Xiao-li MA, Cai-xia ZHOU, Hai-ming DONG, Zhao-yang WU, Jian-xin YANG, authorCompany=null, correspAuthors=Jian-xin YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707001533395711, articleId=1291707000950387453, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=虎杖及有效成分治疗非酒精性脂肪性肝病作用机制的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

非酒精性脂肪性肝病（NAFLD）是一种由多种因素引起的以肝脂肪过度蓄积为主要特征的代谢性疾病。近年来，随着人们生活方式的改变，其发病率逐年上升，已成为威胁公众健康的重要问题。中药因其多成分、多途径、多靶点的特点，在NAFLD的防治中展现出了独特的优势与研究价值。虎杖作为其中的代表性药物，已被证实具有抗炎、抗氧化、保肝等多种药理活性，然其具体活性成分及作用机理尚未完全阐明。为此，本文系统综述了虎杖及有效成分治疗NAFLD的中英文文献，结果表明虎杖治疗NAFLD的核心活性成分包括白藜芦醇、虎杖苷、大黄素等，作用机制至少涉及调节脂质代谢、调节糖代谢及胰岛素抵抗、抗炎、抗氧化应激及调节肠道菌群等多种途径，可为虎杖的深入机制研究与临床应用提供思路和参考。

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马小丽（1999-），女，硕士研究生，主要从事中西医结合防治消化系统疾病方面的研究

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马小丽（1999-），女，硕士研究生，主要从事中西医结合防治消化系统疾病方面的研究

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