Article(id=1291707007497696049, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.24.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1760457600000, receivedDateStr=2025-10-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896549342, onlineDateStr=2026-08-05, pubDate=1766851200000, pubDateStr=2025-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896549342, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896549342, creator=13701087609, updateTime=1785896549342, updator=13701087609, issue=Issue{id=1291706966187991876, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='24', pageStart='3451', pageEnd='3600', issueExtLink='null', onlineDate='null', pubDate='1766851200000', pubDateStr='2025-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896539494, creator='13701087609', updateTime=1785998798662, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292135872292479273, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292135872296673578, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3530, endPage=3535, ext={EN=ArticleExt(id=1291707007963263794, articleId=1291707007497696049, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Pharmaceutical care for anticoagulation therapy following mechanical aortic valve replacement complicated by lower extremity arterial embolism, columnId=1246531412023730850, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Medication Comment, runingTitle=null, highlight=null, articleAbstract=
Objective To provide anticoagulation recommendations and optimize pharmacotherapy for a patient with lower extremity arterial embolism following aortic valve replacement by integrating pharmacogenomics and drug-drug interactions with medication education.
Methods A clinical pharmacist participated in the anticoagulation therapy and medication monitoring for a patient who underwent emergency surgery due to lower extremity arterial embolism after mechanical aortic valve replacement. Based on an analysis of the patient′s individual condition and clinical characteristics, and with reference to guidelines and evidence-based literature, the clinical pharmacist guided the perioperative anticoagulation regimen. Factors influencing the effect of warfarin were also analyzed to optimize its dosage.
Results The patient′s lower extremity arterial embolism improved, and the patient was discharged with favorable follow-up outcomes.
Conclusion This case provides a reference for clinical pharmacists in managing anticoagulation therapy for patients with lower extremity arterial embolism after mechanical heart valve replacement.
, authors=Wei-wei ZHANG
1a, 2, 3, Kang SHE
1b, Min YANG
1b, Zi-ning WANG
1a, authorsList=Wei-wei ZHANG, Kang SHE, Min YANG, Zi-ning WANG, authorCompany=null, correspAuthors=Zi-ning WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707008667906867, articleId=1291707007497696049, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=主动脉瓣机械瓣膜置换术后合并下肢动脉栓塞抗凝治疗的药学监护, columnId=1246531412271194800, journalTitle=中国临床药理学杂志, columnName=用药点评, runingTitle=null, highlight=null, articleAbstract=
目的 结合药物基因组学、药物相互作用及用药教育的综合药学服务为1例主动脉瓣瓣膜置换术后下肢动脉栓塞患者提供及优化抗凝药物使用方案。
方法 临床药师参与1例主动脉瓣机械瓣膜置换术后合并下肢动脉栓塞并进行紧急手术患者的抗凝治疗及用药监护,通过对患者个体情况及病情特点进行分析,同时结合指南、文献相关循证依据,对患者围手术期抗凝方案进行指导,同时对影响华法林作用的因素进行分析并优化其使用剂量。
结论 本例报告为临床药师针对心脏机械瓣膜置换术后发生下肢动脉栓塞患者提供相关抗凝用药参考。
, authors=张微微
1a, 2, 3, 佘康
1b, 杨敏
1b, 王梓凝
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张微微(1983-),女,主管药师,主要从事临床药学及医工交叉研究
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2.清华大学 北京清华长庚医院 临床药学科,北京 102218
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