Article(id=1291706992628884447, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.24.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1719676800000, receivedDateStr=2024-06-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896545798, onlineDateStr=2026-08-05, pubDate=1766851200000, pubDateStr=2025-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896545798, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896545798, creator=13701087609, updateTime=1785896545798, updator=13701087609, issue=Issue{id=1291706966187991876, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='24', pageStart='3451', pageEnd='3600', issueExtLink='null', onlineDate='null', pubDate='1766851200000', pubDateStr='2025-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896539494, creator='13701087609', updateTime=1785998798662, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292135872292479273, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292135872296673578, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3518, endPage=3523, ext={EN=ArticleExt(id=1291706992821822432, articleId=1291706992628884447, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=
ACOT8 pan-cancer analysis and its potential role in the prognosis of prostate cancer patients, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To clarify the role of acyl-CoA thioesterase 8 (ACOT8) across cancers, particularly its prognostic value, and its links to ferroptosis and the immune microenvironment in prostate cancer (PCa).
Methods Using data from The Cancer Genome Atlas (TCGA), R software was used to analyze the gene differential expression of ACOT8 in pan-cancer and the correlation between prognosis. The single sample gene set enrichment analysis (ssGSEA), cell-type identification by estimating relative subsets of known RNA transcripts (CIBERSORT) and tumor immune dysfunction and exclusion (TIDE) algorithms were employed to assess correlations with ferroptosis and immune cell infiltration.
Results ACOT8 was upregulated in 11 cancers and high expression predicted poor survival, most significantly in PCa. In PCa, ACOT8 expression was negatively correlated with ferroptosis activity and positively correlated with immunosuppressive cells.
Conclusion ACOT8 is a poor prognostic marker in PCa, potentially by inhibiting ferroptosis and promoting an immunosuppressive microenvironment.
, authors=Mo ZHANG
1, Jie CHEN
2, 3, Rui-fen XUE
2, 3, Zhuo-na RONG
3, authorsList=Mo ZHANG, Jie CHEN, Rui-fen XUE, Zhuo-na RONG, authorCompany=null, correspAuthors=Zhuo-na RONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291706993086063585, articleId=1291706992628884447, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=
ACOT8泛癌分析及其在前列腺癌患者预后中的潜在作用, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 通过生物信息学方法分析酰基辅酶A硫酯酶8(ACOT8)在多种肿瘤尤其是前列腺癌中的功能作用,评估在人类泛癌中的差异表达和预后价值,探讨ACOT8与铁死亡和免疫微环境之间的相关性。
方法 癌症样本数据来自癌症基因组图谱数据库(TCGA),利用R软件对ACOT8在泛癌中的基因差异表达和预后相关性进行分析,使用单样本基因集富集分析(ssGSEA)算法分析ACOT8与铁死亡相关性,利用CIBERSORT方法和肿瘤免疫功能障碍与排斥(TIDE)算法分析ACOT8与免疫微环境相关性。
结果 在33种肿瘤类型中,ACOT8在11种肿瘤中表达升高,并且表达较高的患者生存预后更差,这在前列腺癌中表现更为明显。本研究进一步发现ACOT8可能与前列腺癌铁死亡抑制和免疫抑制有关。
结论 ACOT8在前列腺癌中高表达,是前列腺癌的不良预后因素,抑制ACOT8的表达或许有助于诱导肿瘤细胞铁死亡以及改善肿瘤免疫抑制状态。
, authors=张默
1, 陈洁
2, 3, 薛瑞芬
2, 3, 戎卓娜
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张默(1989-),女,硕士研究生,从事肿瘤相关的临床和基础研究
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