Article(id=1291706992628884447, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.24.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1719676800000, receivedDateStr=2024-06-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896545798, onlineDateStr=2026-08-05, pubDate=1766851200000, pubDateStr=2025-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896545798, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896545798, creator=13701087609, updateTime=1785896545798, updator=13701087609, issue=Issue{id=1291706966187991876, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='24', pageStart='3451', pageEnd='3600', issueExtLink='null', onlineDate='null', pubDate='1766851200000', pubDateStr='2025-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896539494, creator='13701087609', updateTime=1785998798662, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292135872292479273, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292135872296673578, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3518, endPage=3523, ext={EN=ArticleExt(id=1291706992821822432, articleId=1291706992628884447, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=ACOT8 pan-cancer analysis and its potential role in the prognosis of prostate cancer patients, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective

To clarify the role of acyl-CoA thioesterase 8 (ACOT8) across cancers, particularly its prognostic value, and its links to ferroptosis and the immune microenvironment in prostate cancer (PCa).

Methods

Using data from The Cancer Genome Atlas (TCGA), R software was used to analyze the gene differential expression of ACOT8 in pan-cancer and the correlation between prognosis. The single sample gene set enrichment analysis (ssGSEA), cell-type identification by estimating relative subsets of known RNA transcripts (CIBERSORT) and tumor immune dysfunction and exclusion (TIDE) algorithms were employed to assess correlations with ferroptosis and immune cell infiltration.

Results

ACOT8 was upregulated in 11 cancers and high expression predicted poor survival, most significantly in PCa. In PCa, ACOT8 expression was negatively correlated with ferroptosis activity and positively correlated with immunosuppressive cells.

Conclusion

ACOT8 is a poor prognostic marker in PCa, potentially by inhibiting ferroptosis and promoting an immunosuppressive microenvironment.

, authors=Mo ZHANG1, Jie CHEN2, 3, Rui-fen XUE2, 3, Zhuo-na RONG3, authorsList=Mo ZHANG, Jie CHEN, Rui-fen XUE, Zhuo-na RONG, authorCompany=null, correspAuthors=Zhuo-na RONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291706993086063585, articleId=1291706992628884447, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=ACOT8泛癌分析及其在前列腺癌患者预后中的潜在作用, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的

通过生物信息学方法分析酰基辅酶A硫酯酶8(ACOT8)在多种肿瘤尤其是前列腺癌中的功能作用,评估在人类泛癌中的差异表达和预后价值,探讨ACOT8与铁死亡和免疫微环境之间的相关性。

方法

癌症样本数据来自癌症基因组图谱数据库(TCGA),利用R软件对ACOT8在泛癌中的基因差异表达和预后相关性进行分析,使用单样本基因集富集分析(ssGSEA)算法分析ACOT8与铁死亡相关性,利用CIBERSORT方法和肿瘤免疫功能障碍与排斥(TIDE)算法分析ACOT8与免疫微环境相关性。

结果

在33种肿瘤类型中,ACOT8在11种肿瘤中表达升高,并且表达较高的患者生存预后更差,这在前列腺癌中表现更为明显。本研究进一步发现ACOT8可能与前列腺癌铁死亡抑制和免疫抑制有关。

结论

ACOT8在前列腺癌中高表达,是前列腺癌的不良预后因素,抑制ACOT8的表达或许有助于诱导肿瘤细胞铁死亡以及改善肿瘤免疫抑制状态。

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张默(1989-),女,硕士研究生,从事肿瘤相关的临床和基础研究

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戎卓娜,助理研究员 MP: 18342216422 E-mail:
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ACOT8泛癌分析及其在前列腺癌患者预后中的潜在作用
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张默 1 , 陈洁 2, 3 , 薛瑞芬 2, 3 , 戎卓娜 3
中国临床药理学杂志 | 临床与基础桥接研究 2025,41(24): 3518-3523
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中国临床药理学杂志 |临床与基础桥接研究 2025 , 41 (24) : 3518 -3523
ACOT8泛癌分析及其在前列腺癌患者预后中的潜在作用
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张默1, 陈洁2, 3, 薛瑞芬2, 3, 戎卓娜3
作者信息
  • 1.北京大学第一医院 中西医结合科,北京,100034
  • 2.徐州医科大学 药学院,江苏 徐州,221009
  • 3.北京大学第一医院 药剂科,北京,100034
通讯作者:
戎卓娜,助理研究员 MP: 18342216422 E-mail:
作者简介:

张默(1989-),女,硕士研究生,从事肿瘤相关的临床和基础研究

ACOT8 pan-cancer analysis and its potential role in the prognosis of prostate cancer patients
Mo ZHANG1, Jie CHEN2, 3, Rui-fen XUE2, 3, Zhuo-na RONG3
Affiliations
  • 1.Department of Integrative Medicine, Peking University First Hospital, Beijing 100034, China
  • 2.School of Pharmacy, Xuzhou Medical University, Xuzhou 221009, Jiangsu Province, China
  • 3.Department of Pharmacy, Peking University First Hospital, Beijing, 100034, China
出版时间: 2025-12-28 doi: 10.13699/j.cnki.1001-6821.2025.24.011
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目的

通过生物信息学方法分析酰基辅酶A硫酯酶8(ACOT8)在多种肿瘤尤其是前列腺癌中的功能作用,评估在人类泛癌中的差异表达和预后价值,探讨ACOT8与铁死亡和免疫微环境之间的相关性。

方法

癌症样本数据来自癌症基因组图谱数据库(TCGA),利用R软件对ACOT8在泛癌中的基因差异表达和预后相关性进行分析,使用单样本基因集富集分析(ssGSEA)算法分析ACOT8与铁死亡相关性,利用CIBERSORT方法和肿瘤免疫功能障碍与排斥(TIDE)算法分析ACOT8与免疫微环境相关性。

结果

在33种肿瘤类型中,ACOT8在11种肿瘤中表达升高,并且表达较高的患者生存预后更差,这在前列腺癌中表现更为明显。本研究进一步发现ACOT8可能与前列腺癌铁死亡抑制和免疫抑制有关。

结论

ACOT8在前列腺癌中高表达,是前列腺癌的不良预后因素,抑制ACOT8的表达或许有助于诱导肿瘤细胞铁死亡以及改善肿瘤免疫抑制状态。

酰基辅酶A硫酯酶8  /  预后  /  铁死亡  /  免疫微环境  /  泛癌分析
Objective

To clarify the role of acyl-CoA thioesterase 8 (ACOT8) across cancers, particularly its prognostic value, and its links to ferroptosis and the immune microenvironment in prostate cancer (PCa).

Methods

Using data from The Cancer Genome Atlas (TCGA), R software was used to analyze the gene differential expression of ACOT8 in pan-cancer and the correlation between prognosis. The single sample gene set enrichment analysis (ssGSEA), cell-type identification by estimating relative subsets of known RNA transcripts (CIBERSORT) and tumor immune dysfunction and exclusion (TIDE) algorithms were employed to assess correlations with ferroptosis and immune cell infiltration.

Results

ACOT8 was upregulated in 11 cancers and high expression predicted poor survival, most significantly in PCa. In PCa, ACOT8 expression was negatively correlated with ferroptosis activity and positively correlated with immunosuppressive cells.

Conclusion

ACOT8 is a poor prognostic marker in PCa, potentially by inhibiting ferroptosis and promoting an immunosuppressive microenvironment.

acyl-CoA thioesterase 8  /  prognosis  /  ferroptosis  /  immune microenvironment  /  pan-cancer analysis
张默, 陈洁, 薛瑞芬, 戎卓娜. ACOT8泛癌分析及其在前列腺癌患者预后中的潜在作用. 中国临床药理学杂志, 2025 , 41 (24) : 3518 -3523 . DOI: 10.13699/j.cnki.1001-6821.2025.24.011
Mo ZHANG, Jie CHEN, Rui-fen XUE, Zhuo-na RONG. ACOT8 pan-cancer analysis and its potential role in the prognosis of prostate cancer patients[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (24) : 3518 -3523 . DOI: 10.13699/j.cnki.1001-6821.2025.24.011
  • 北京市自然科学基金资助项目(L248076)
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doi: 10.13699/j.cnki.1001-6821.2025.24.011
  • 接收时间:2024-06-30
  • 首发时间:2026-08-05
  • 出版时间:2025-12-28
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  • 收稿日期:2024-06-30
基金
北京市自然科学基金资助项目(L248076)
作者信息
    1.北京大学第一医院 中西医结合科,北京,100034
    2.徐州医科大学 药学院,江苏 徐州,221009
    3.北京大学第一医院 药剂科,北京,100034

通讯作者:

戎卓娜,助理研究员 MP: 18342216422 E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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