Article(id=1291706979278418532, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.24.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1750780800000, receivedDateStr=2025-06-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896542614, onlineDateStr=2026-08-05, pubDate=1766851200000, pubDateStr=2025-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896542614, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896542614, creator=13701087609, updateTime=1785896542614, updator=13701087609, issue=Issue{id=1291706966187991876, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='24', pageStart='3451', pageEnd='3600', issueExtLink='null', onlineDate='null', pubDate='1766851200000', pubDateStr='2025-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896539494, creator='13701087609', updateTime=1785998798662, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292135872292479273, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292135872296673578, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3491, endPage=3498, ext={EN=ArticleExt(id=1291706979479745125, articleId=1291706979278418532, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Study on
in vitro activity of ceftobiprole, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To evaluate in vitro activity of ceftobiprole against clinical isolated bacteria in recent years in China.
Methods The minimal inhibitory concentrations (MICs) were determined by the microbroth dilution method.
Results A total of 948 clinical isolates collected from nationwide between 2019 to 2020 were studied. Ceftobiprole exhibited excellent antibacterial activity against gram-positive cocci, the value of MIC90 was 0.5 mg·L-1 for methicillin susceptible Staphylococcus spp and susceptibility rates of methicillin resistant Staphylococcus aureus (MRSA) were 93.1%, which was better than that of ceftaroline (72.3%). The MIC values of ceftobiprole against penicillin nonsusceptible Streptococcus pneumoniae (PNSSP) ranged from 0.06 to 1 mg·L-1, with 80.0% susceptibility rate . The values of MIC90 of ceftobiprole were ≤2 mg·L-1 for other streptococci and Enterococcus faecalis. Against Gram-negative bacteria, ceftobiprole also showed better antibacterial activity against non-extended spectrum β-lactamases (ESBLs) Escherichia coli, non-ESBLs Klebsiella pneumoniae, ampicillin-susceptible Haemophilus influenzae and Moraxella catarrhalis, the values of MIC90 ≤0.5 mg·L-1 and susceptible strains more than 98.1%. The activity of ceftobiprole against Pseudomonas aeruginosa was similar to that of ceftazidime and cefepime.
Conclusion Ceftobiprole showed excellent antibacterial activity against clinical isolates, include MRSA, PNSSP, and Haemophilus influenzae in recent years in China, which similar to the surveillance results in Europe and America. The clinical prospect is worthy of expectation.
, authors=Feng XUE, Jia ZHANG, Yun LI, authorsList=Feng XUE, Jia ZHANG, Yun LI, authorCompany=null, correspAuthors=Yun LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291706979874009702, articleId=1291706979278418532, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=头孢比罗体外抗菌作用研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 评价头孢比罗对近年临床常见分离菌的体外抗菌活性。
方法 最低抑菌浓度（MIC）测定采用标准微量肉汤二倍稀释法。
结果 对2019~2020年间全国范围内临床分离948株细菌进行了MIC测定。结果显示：头孢比罗对革兰阳性菌具有很好抗菌作用，对甲氧西林敏感葡萄球菌MIC90值为0.5 mg·L-1。甲氧西林耐药金黄色葡萄球菌（MRSA）对其敏感率为93.1%，优于头孢洛林（72.3%）。头孢比罗对青霉素不敏感肺炎链球菌（PNSSP）MIC值在0.06～1 mg·L-1，细菌敏感率为80.0%；对其他链球菌及粪肠球菌MIC90值≤2 mg·L-1。革兰阴性菌中，头孢比罗对超广谱β-内酰胺酶（ESBLs）阴性大肠埃希菌、肺炎克雷伯菌以及氨苄西林敏感流感嗜血杆菌、卡他莫拉菌同样具有很好抗菌作用，MIC90值≤0.5 mg·L-1，菌株敏感率≥98.1%。头孢比罗对铜绿假单胞菌抗菌作用与头孢他啶、头孢吡肟相似。
结论 头孢比罗对国内近年临床分离常见革兰阳性、阴性致病菌，包括MRSA、PNSSP等均有很好抗菌作用，与欧美监测结果相似。临床前景值得期待。
, authors=薛峰, 张佳, 李耘, authorsList=薛峰, 张佳, 李耘, authorCompany=null, correspAuthors=李耘, authorNote=
薛峰（1971-），男，主管技师，主要从事抗菌药物临床前药效研究
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