Article(id=1291706967760851678, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.24.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1759939200000, receivedDateStr=2025-10-09, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896539869, onlineDateStr=2026-08-05, pubDate=1766851200000, pubDateStr=2025-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896539869, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896539869, creator=13701087609, updateTime=1785896539869, updator=13701087609, issue=Issue{id=1291706966187991876, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='24', pageStart='3451', pageEnd='3600', issueExtLink='null', onlineDate='null', pubDate='1766851200000', pubDateStr='2025-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896539494, creator='13701087609', updateTime=1785998798662, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292135872292479273, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292135872296673578, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3482, endPage=3490, ext={EN=ArticleExt(id=1291706969430184673, articleId=1291706967760851678, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Study on the
in vitro antibacterial activity of dequalinium chloride against common pathogens in oral infections, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To evaluate the in vitro antibacterial effects and post-antibiotic effect (PAE) of dequalinium chloride against common pathogens isolated from oral infections in China in recent years.
Methods The minimum inhibitory concentration (MIC) was determined by the standard microbroth or agar (for anaerobes) two-fold dilution method; the minimum bactericidal concentration (MBC) was determined by the broth two-fold dilution method; time-kill curves and PAE were determined by the colony count method.
Results MICs of dequalinium chloride and commonly used antimicrobial drugs were determined for 274 bacterial strains from 22 hospitals in 19 cities across China. Result showed that, for Gram-positive bacteria, the MIC50 values of dequalinium chloride against Staphylococcus aureus and Streptococcus pyogenes were 1 and 2 mg·L-1, respectively, with MIC90 values of 2 and 4 mg·L-1, respectively. For Streptococcus pneumoniae, Enterococcus faecalis, and the viridans group streptococci, the MIC50 values were 8, 4 and 8 mg·L-1, respectively, while the MIC90 values were 8, and 16 mg·L-1, respectively. Among Gram-negative bacteria, the MIC50 and MIC90 values of dequalinium chloride against Klebsiella pneumoniae were both 64 mg·L-1; and >512 mg·L-1 for MIC50 against Pseudomonas aeruginosa. For 32 strains of anaerobic bacteria, the MIC50 and MIC90 of dequalinium chloride were 16 and 128 mg·L-1, respectively. Dequalinium chloride showed superior antibacterial activity against genera of Peptostreptococcus and Porphyromonas compared to Prevotella. MBC and time-kill curves showed that dequalinium chloride has a good bactericidal effect on Staphylococcus aureus, Streptococcus pyogenes, and oral streptococci, killing bacteria from an initial count of 1.0×105-1.0×106 CFU·mL-1 to 0 at 1-4 times MIC concentration within 4-24 h. It also showed good bactericidal effect on Enterococcus faecalis. The time-kill curves indicating a concentration-dependent characteristic of the drug. The PAE of dequalinium chloride against the above four bacterial strains was between 0.5-1 h.
Conclusion Dequalinium chloride exhibits superior antibacterial activity against Gram-positive bacteria than Gram-negative bacteria and anaerobes, especially against Staphylococcus aureus and Streptococcus pyogenes, warranting further clinical research.
, authors=Shan WANG, Yun LI, Jia ZHANG, Yao-yao LIU, Bo ZHENG, authorsList=Shan WANG, Yun LI, Jia ZHANG, Yao-yao LIU, Bo ZHENG, authorCompany=null, correspAuthors=Bo ZHENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291706970243879654, articleId=1291706967760851678, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=地喹氯铵对口腔感染常见病原菌体外抗菌活性研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 评价地喹氯铵对中国近年来临床分离口腔感染常见病原菌的体外抗菌作用及抗生素后效应（PAE）。
方法 用标准微量肉汤/琼脂（用于厌氧菌）二倍稀释法测定最低抑菌浓度（MIC）；用肉汤二倍稀释法测定最低杀菌浓度（MBC）；用菌落计数法测定杀菌曲线和PAE。
结果 对来自中国19座城市22家医院的274株细菌进行了地喹氯铵和常用抗菌药物的MIC测定。结果显示：革兰氏阳性菌中，地喹氯铵对金黄色葡萄球菌及化脓链球菌的MIC50值分别为1和2 mg·L-1，MIC90值分别为2和4 mg·L-1；对肺炎链球菌、粪肠球菌及草绿色链球菌群MIC50值分别为8、4和8 mg·L-1，MIC90值分别为8、16和16 mg·L-1。革兰氏阴性菌中，地喹氯铵对肺炎克雷伯菌MIC50和MIC90均为64 mg·L-1；地喹氯铵对铜绿假单胞的MIC50为>512 mg·L-1。地喹氯铵对32株厌氧菌的MIC50和MIC90分别为16和128 mg·L-1。地喹氯铵对消化链球菌属和卟啉单胞菌属的抗菌作用优于普雷沃菌属。MBC与杀菌曲线试验表明地喹氯铵对金黄色葡萄球菌、化脓链球菌及口腔链球菌具有很好杀菌作用，在1~4倍MIC浓度，4~24 h，可将细菌由起始1.0×105~1.0×106CFU·mL-1杀灭至0 CFU·mL-1，对粪肠球菌具有较好杀菌作用，杀菌曲线显示该药倾向于浓度依赖性药物特征。地喹氯铵对以上4株菌的PAE在0.5~1 h之间。
结论 地喹氯铵对革兰氏阳性菌的抗菌作用优于革兰氏阴性菌及厌氧菌，尤其是对金黄色葡萄球菌及化脓链球菌具有很好抗菌活性，值得进一步临床研究。
, authors=王珊, 李耘, 张佳, 刘姚姚, 郑波, authorsList=王珊, 李耘, 张佳, 刘姚姚, 郑波, authorCompany=null, correspAuthors=郑波, authorNote=
王珊（1981-），女，主管技师，主要从事抗菌药物临床前药效研究
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