Article(id=1291707131011559813, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.23.014, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1756656000000, receivedDateStr=2025-09-01, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896578791, onlineDateStr=2026-08-05, pubDate=1765900800000, pubDateStr=2025-12-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896578791, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896578791, creator=13701087609, updateTime=1785896578791, updator=13701087609, issue=Issue{id=1291707045514858818, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='23', pageStart='3301', pageEnd='3450', issueExtLink='null', onlineDate='null', pubDate='1765900800000', pubDateStr='2025-12-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896558407, creator='13701087609', updateTime=1785896663780, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707487678390577, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707487682584882, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3399, endPage=3407, ext={EN=ArticleExt(id=1291707131217080710, articleId=1291707131011559813, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of the correlation between hyperuricemia and cardiovascular diseases, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Hyperuricemia (HUA) is a metabolic disorder characterized by abnormally elevated serum uric acid levels, with a rising prevalence worldwide. The potential hazards of HUA and its precise intervention strategies have emerged as a central focus in clinical medicine research. Current research indicates that HUA is closely associated with various systemic diseases, such as cardiovascular and renal diseases. Its pathogenic mechanisms involve multiple pathways, such as oxidative stress, inflammatory factor activation, and urate crystal deposition. However, the treatment of HUA patients with comorbid cardiovascular or renal diseases—particularly those with asymptomatic hyperuricemia (AH)—remains highly controversial. Existing clinical guidelines show significant regional variations, European and American guidelines favor a conservative monitoring approach, while Asian guidelines advocate for earlier intervention. Therefore, to establish the long-term clinical benefits for HUA patients, there is an urgent need for evidence-based medical support through large-scale prospective cohort studies and randomized controlled trials (RCTs). These studies will provide a more reliable foundation for standardized clinical management.

, authors=Xiu-zhen DI1, Xiao-hui WANG1, Hua SUN1, Nan BAI2, authorsList=Xiu-zhen DI, Xiao-hui WANG, Hua SUN, Nan BAI, authorCompany=null, correspAuthors=Nan BAI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707131586179463, articleId=1291707131011559813, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=高尿酸血症与心血管疾病相关性的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

高尿酸血症(HUA)是一种以血清尿酸(SUA)水平异常增高为特征的代谢性疾病,其全球患病率持续上升。HUA潜在危害及其精准干预策略成为临床医学关注的焦点问题。现有研究表明,HUA与心血管疾病、肾疾病等多种疾病存在密切关联,其致病机制涉及氧化应激、炎症因子激活和尿酸结晶沉积等多重通路,对于合并心血管和肾脏等疾病的HUA患者,尤其是无症状高尿酸血症(AH)的治疗存在较大争议。当前临床指南存在明显地域差异,欧美指南倾向于保守观察,而亚洲指南则更支持早期干预。因此,针对HUA患者的长期临床获益,亟需通过大规模前瞻性队列研究和随机对照试验(RCT)提供循证医学的依据,为HUA的规范化管理提供更可靠的临床依据。

, authors=邸秀珍1, 王晓晖1, 孙华1, 白楠2, authorsList=邸秀珍, 王晓晖, 孙华, 白楠, authorCompany=null, correspAuthors=白楠, authorNote=

邸秀珍(1975-),女,副主任药师,主要从事临床药学的相关研究

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白楠,副主任药师 Tel: (010)66937166 E-mail:
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高尿酸血症与心血管疾病相关性的研究现状
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邸秀珍 1 , 王晓晖 1 , 孙华 1 , 白楠 2
中国临床药理学杂志 | 综述 2025,41(23): 3399-3407
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中国临床药理学杂志 |综述 2025 , 41 (23) : 3399 -3407
高尿酸血症与心血管疾病相关性的研究现状
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邸秀珍1, 王晓晖1, 孙华1, 白楠2
作者信息
  • 1.中国人民解放军总医院 京南医疗区 北京 100841
  • 2.中国人民解放军总医院第一医学 伦理委员会办公室,北京 100853
通讯作者:
白楠,副主任药师 Tel: (010)66937166 E-mail:
作者简介:

邸秀珍(1975-),女,副主任药师,主要从事临床药学的相关研究

Research status of the correlation between hyperuricemia and cardiovascular diseases
Xiu-zhen DI1, Xiao-hui WANG1, Hua SUN1, Nan BAI2
Affiliations
  • 1.Jingnan Medical District, General Hospital of Chinese People’s Liberation Army, Beijing 100841, China
  • 2.The Office of the Medical Ethics Committee, The First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100853, China
出版时间: 2025-12-17 doi: 10.13699/j.cnki.1001-6821.2025.23.014
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高尿酸血症(HUA)是一种以血清尿酸(SUA)水平异常增高为特征的代谢性疾病,其全球患病率持续上升。HUA潜在危害及其精准干预策略成为临床医学关注的焦点问题。现有研究表明,HUA与心血管疾病、肾疾病等多种疾病存在密切关联,其致病机制涉及氧化应激、炎症因子激活和尿酸结晶沉积等多重通路,对于合并心血管和肾脏等疾病的HUA患者,尤其是无症状高尿酸血症(AH)的治疗存在较大争议。当前临床指南存在明显地域差异,欧美指南倾向于保守观察,而亚洲指南则更支持早期干预。因此,针对HUA患者的长期临床获益,亟需通过大规模前瞻性队列研究和随机对照试验(RCT)提供循证医学的依据,为HUA的规范化管理提供更可靠的临床依据。

高尿酸血症  /  无症状高尿酸血症  /  心血管疾病  /  发病机制  /  治疗

Hyperuricemia (HUA) is a metabolic disorder characterized by abnormally elevated serum uric acid levels, with a rising prevalence worldwide. The potential hazards of HUA and its precise intervention strategies have emerged as a central focus in clinical medicine research. Current research indicates that HUA is closely associated with various systemic diseases, such as cardiovascular and renal diseases. Its pathogenic mechanisms involve multiple pathways, such as oxidative stress, inflammatory factor activation, and urate crystal deposition. However, the treatment of HUA patients with comorbid cardiovascular or renal diseases—particularly those with asymptomatic hyperuricemia (AH)—remains highly controversial. Existing clinical guidelines show significant regional variations, European and American guidelines favor a conservative monitoring approach, while Asian guidelines advocate for earlier intervention. Therefore, to establish the long-term clinical benefits for HUA patients, there is an urgent need for evidence-based medical support through large-scale prospective cohort studies and randomized controlled trials (RCTs). These studies will provide a more reliable foundation for standardized clinical management.

hyperuricemia  /  asymptomatic hyperuricemia  /  cardiovascular disease  /  pathogenesis  /  treatment
邸秀珍, 王晓晖, 孙华, 白楠. 高尿酸血症与心血管疾病相关性的研究现状. 中国临床药理学杂志, 2025 , 41 (23) : 3399 -3407 . DOI: 10.13699/j.cnki.1001-6821.2025.23.014
Xiu-zhen DI, Xiao-hui WANG, Hua SUN, Nan BAI. Research status of the correlation between hyperuricemia and cardiovascular diseases[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (23) : 3399 -3407 . DOI: 10.13699/j.cnki.1001-6821.2025.23.014

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2025年第41卷第23期
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doi: 10.13699/j.cnki.1001-6821.2025.23.014
  • 接收时间:2025-09-01
  • 首发时间:2026-08-05
  • 出版时间:2025-12-17
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  • 收稿日期:2025-09-01
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    1.中国人民解放军总医院 京南医疗区 北京 100841
    2.中国人民解放军总医院第一医学 伦理委员会办公室,北京 100853

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白楠,副主任药师 Tel: (010)66937166 E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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