Article(id=1291707271772402623, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.23.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1763308800000, receivedDateStr=2025-11-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896612351, onlineDateStr=2026-08-05, pubDate=1765900800000, pubDateStr=2025-12-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896612351, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896612351, creator=13701087609, updateTime=1785896612351, updator=13701087609, issue=Issue{id=1291707045514858818, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='23', pageStart='3301', pageEnd='3450', issueExtLink='null', onlineDate='null', pubDate='1765900800000', pubDateStr='2025-12-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896558407, creator='13701087609', updateTime=1785896663780, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707487678390577, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707487682584882, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3382, endPage=3390, ext={EN=ArticleExt(id=1291707272162472896, articleId=1291707271772402623, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Pathological mechanism and new progress in drug treatment of metabolic dysfunction-associated steatotic liver disease, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

The global prevalence and incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) are steadily increasing, with the situation being particularly pronounced in China. Currently, MASLD has become the most common form of chronic liver disease in the country, posing a serious threat to public health. The pathogenesis of MASLD is highly complex, involving multiple contributing factors, which presents significant challenges for researchers exploring treatment strategies. This article provides a comprehensive review of MASLD, with a focus on elucidating its pathogenesis and current advances in therapeutic research, aiming to offer valuable insights for future studies and contribute to addressing this serious health challenge.

, authors=Xin-yue WANG¹, Yan-xi LI¹, Yan ZHANG², authorsList=Xin-yue WANG, Yan-xi LI, Yan ZHANG, authorCompany=null, correspAuthors=Yan ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707272716121025, articleId=1291707271772402623, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=代谢相关脂肪性肝病的病理机制及药物治疗新进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

全球代谢相关脂肪性肝病（MASLD）的患病率和发病率呈现出不断增高的态势，尤以我国较为严重，目前该疾病已经成为我国最主要的慢性肝病类型，严重威胁着国民的健康。MASLD的发病机制极为复杂，涉及多个层面的因素，这使得研究人员在探索治疗方法时面临重重困难。本文针对MASLD进行了全面的综述，着重探讨了该疾病的发病机制及其治疗方面的研究现状，以期为MASLD后续的研究工作提供有价值的依据，助力应对这一严重的健康挑战。

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