Article(id=1291707263006302313, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.23.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1761494400000, receivedDateStr=2025-10-27, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896610260, onlineDateStr=2026-08-05, pubDate=1765900800000, pubDateStr=2025-12-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896610260, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896610260, creator=13701087609, updateTime=1785896610260, updator=13701087609, issue=Issue{id=1291707045514858818, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='23', pageStart='3301', pageEnd='3450', issueExtLink='null', onlineDate='null', pubDate='1765900800000', pubDateStr='2025-12-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896558407, creator='13701087609', updateTime=1785896663780, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707487678390577, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707487682584882, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3350, endPage=3357, ext={EN=ArticleExt(id=1291707263597699178, articleId=1291707263006302313, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Exploring the mechanism of Sijunzi decoction ameliorates pancreatic insulin resistance in T2DM rats: A focus on the PI3K/AKT pathway, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effect and underlying mechanism of Sijunzi Decoction in ameliorating insulin resistance (IR) within the pancreatic islets of rats with type 2 diabetes mellitus (T2DM).
Methods A total of 40 Sprague-Dawley (SD) rats were randomly divided into control group (n=10, fed with normal diet) and high-sugar and high-fat group [n=30, fed with high-sugar and high-fat diet coupled with intraperitoneal injection of streptozotocin (STZ) to create a type 2 diabetes mellitus (T2DM) model]. The smoothly modeled SD rats were further randomly assigned into model group, positive control group (0.003 g·mL-1) and experimental group (0.848 g·mL-1). The normal group and model group were given distilled water by gavage, while the other two groups were administered the corresponding drugs by gavage for 4 consecutive weeks. Fasting blood glucose (FBG) was measured using a blood glucose meter. Serum levels of fasting insulin (FINS), total cholesterol (TC), total triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in rats of each group were detected with commercial assay kits. The pancreatic index (PI) was calculated based on the detection of pancreatic tissue. Reverse transcription-polymerase chain reaction (RT-PCR) was employed to determine the mRNA expression levels of related proteins, and Western blotting was performed to ascertain the formulation standards of correlated total proteins.
Results The FBG, FINS, TC, TG, HDL-C, LDL-C and PI in the model group and experimental group were (13.60±0.61) mmol·L-1 vs. (9.73±0.43) mmol·L-1, (15.24±0.76) mIU·L-1 vs. (12.39±1.13) mIU·L-1, (5.42±0.41) mmol·L-1 vs. (3.76±0.26) mmol·L-1, (1.49±0.26) mmol·L-1 vs. (0.65±0.05) mmol·L-1, (0.82±0.06) mmol·L-1 vs. (1.12±0.08) mmol·L-1, (4.82±0.43) mmol·L-1 vs. (3.02±0.42) mmol·L-1, and (0.27±0.09)% vs. (0.34±0.02)%, respectively. The mRNA expression levels of INSR, IRS-1, PI3K, AKT, GLUT4, GSK-3β, and FOXO1 were 0.44±0.16 vs. 0.61±0.16, 0.48±0.13 vs. 0.72±0.16, 0.62±0.30 vs. 0.84±0.12, 0.74±0.20 vs. 0.92±0.02, 0.48±0.22 vs. 0.78±0.24, 1.90±0.16 vs. 1.56±0.25, and 1.83±0.16 vs. 1.60±0.21, respectively. The total protein expression levels of INSR, IRS-1, PI3K, AKT, GLUT4, GSK-3β, and FOXO1 were 0.59±0.29 vs. 0.82±0.18, 0.65±0.28 vs. 0.72±0.16, 0.49±0.14 vs. 0.74±0.15, 0.50±0.17 vs. 0.68±0.12, 0.65±0.28 vs. 0.86±0.14, 2.73±0.19 vs. 2.50±0.22, and 1.61±0.49 vs. 1.21±0.35, respectively. Compared with the model group, all the above indicators in the experimental group showed statistically significant differences (P<0.001, P<0.01, P<0.05).
Conclusion Sijunzi Decoction can improve pancreatic insulin resistance (IR) in rats with type 2 diabetes mellitus (T2DM) by regulating the expression of 7 signaling factors in the upstream, middle and downstream of the PI3K/AKT signaling pathway.
, authors=Xue-shan DU, Chun-long XUE, Shao-bo YANG, Xi-ya ZHANG, Jie REN, Xiu-jun DUAN, authorsList=Xue-shan DU, Chun-long XUE, Shao-bo YANG, Xi-ya ZHANG, Jie REN, Xiu-jun DUAN, authorCompany=null, correspAuthors=Xiu-jun DUAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707264054878315, articleId=1291707263006302313, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于PI3K/AKT通路探究四君子汤改善T2DM大鼠胰腺部位胰岛素抵抗的机制研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究四君子汤改善2型糖尿病（T2DM）大鼠胰腺胰岛素抵抗（IR）的作用及机制。
方法 将40只SD大鼠分为正常组（n=10，正常饲料）和高糖高脂组[n=10，高糖高脂饲料结合链脲佐菌素（STZ）腹腔注射构建T2DM模型]，造模成功的SD大鼠随机分为模型组、对照组（0.003 g·mL-1）和实验组（0.848 g·mL-1），正常组和模型组灌胃蒸馏水，其余2组分别灌胃相应药物，连续给药4周。用血糖仪测定空腹血糖（FBG），用试剂盒检测各组大鼠血清空腹胰岛素（FINS）、总胆固醇（TC）、总甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C），用胰腺组织检测胰腺指数（PI），用逆转录聚合酶链式反应法检测相关蛋白mRNA的表达，用蛋白印迹法检测相关总蛋白的表达。
结果 模型组和实验组的FBG分别为（13.60±0.61）和（9.73±0.43）mmol·L-1，FINS分别为（15.24±0.76）和（12.39±1.13）mIU·L-1，TC分别为（5.42±0.41）和（3.76±0.26）mmoL·L-1，TG分别为（1.49±0.26）和（0.65±0.05）mmoL·L-1，HDL-C分别为（0.82±0.06）和（1.12±0.08）mmoL·L-1，LDL-C分别为（4.82±0.43）和（3.02±0.42）mmoL·L-1，PI分别为（0.27±0.09）%和（0.34±0.02）%，INSR mRNA表达水平分别为0.44±0.16和0.61±0.16，IRS-1 mRNA表达水平分别为0.48±0.13和0.72±0.16，PI3K mRNA表达水平分别为0.62±0.30和0.84±0.12，AKT mRNA表达水平分别为0.74±0.20和0.92±0.02，GLUT4 mRNA表达水平分别为0.48±0.22和0.78±0.24，GSK-3β mRNA表达水平分别为1.90±0.16和1.56±0.25，FOXO1 mRNA表达水平分别为1.83±0.16和1.60±0.21，INSR总蛋白表达水平分别为0.59±0.29和0.82±0.18，IRS-1总蛋白表达水平分别为0.65±0.28和0.72±0.16，PI3K总蛋白表达水平分别为0.49±0.14和0.74±0.15，AKT总蛋白表达水平分别为0.50±0.17和0.68±0.12，GLUT4总蛋白表达水平分别为0.65±0.28和0.86±0.14，GSK-3β总蛋白表达水平分别为2.73±0.19和2.50±0.22，FOXO1总蛋白表达水平分别为1.61±0.49和1.21±0.35，实验组的上述指标与模型组比较，在统计学上差异具有统计学意义（P<0.001，P<0.01，P<0.05）。
结论 四君子汤可通过调节PI3K/AKT信号通路上、中、下游7个信号因子的表达改善T2DM大鼠胰腺IR。
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杜雪珊（2000-），女，硕士研究生，主要从事中药制剂方面的研究
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