Article(id=1291707284766356454, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.23.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1761753600000, receivedDateStr=2025-10-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896615448, onlineDateStr=2026-08-05, pubDate=1765900800000, pubDateStr=2025-12-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896615448, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896615448, creator=13701087609, updateTime=1785896615448, updator=13701087609, issue=Issue{id=1291707045514858818, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='23', pageStart='3301', pageEnd='3450', issueExtLink='null', onlineDate='null', pubDate='1765900800000', pubDateStr='2025-12-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896558407, creator='13701087609', updateTime=1785896663780, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707487678390577, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707487682584882, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3335, endPage=3342, ext={EN=ArticleExt(id=1291707285328393191, articleId=1291707284766356454, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=The effects of apple polyphenols on lung function and immune imbalance in rats with acute exacerbation of chronic obstructive pulmonary disease by adjusting the
miR-21-5
p/SKP2 pathway, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the effects of apple polyphenols (AP) on lung function and immune imbalance in rats with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) by adjusting the miR-21-5p/SKP2 pathway.
Methods The stable stage of COPD was established by cigarette smoking and endotoxin infusion, and then AECOPD rats were established by nasal infusion of Staphylococcus aureus bacterial solution. They were randomly assigned into the AECOPD group, the AP-25 group, the AP-100 group, the dexamethasone group, the AP-100+NC agomir group, and the AP-100+miR-21-5p agomir group. And rats intervened with normal saline were as the control group. Subsequently, tracheal intubation was performed to measure the peak expiratory and inspiratory flow rates (PEF, PIF), and the ratio of forced expiratory volume to forced vital capacity in 0.3 seconds (FEV0.3/FVC). Serum was collected to measure the levels of tumor necrosis factor -α (TNF-α) and interleukin-6 (IL-6). Bronchoalveolar lavage fluid (BALF) was recovered, and the numbers of neutrophils, lymphocytes and macrophages were determined. Left lung lobe sections were prepared, and lung tissue lesions and scores were observed. The right lung tissue of rats was taken. The proportions of Th17 and Treg cells, the mRNA expression of miR-21-5p and SKP2, and the protein expression of retinoic acid-related orphan receptor γt (RORγt), IL-17A, forkhead box protein P3 (Foxp3), IL-10 and SKP2 in the lung tissue were detected.
Results The AECOPD group had higher RORγt, IL-17A, miR-21-5p, TNF-α, IL-6, macrophages, neutrophils, lymphocytes, Th17 cell proportion, and Th17/Treg than the control group, and had lower Foxp3, IL-10, SKP2 mRNA and protein expression, Treg cell proportion, PEF, PIF, and FEV0.3/FVC than the control group (P<0.05). The AP-25 group, AP-100 group and dexamethasone group had lower RORγt, IL-17A, miR-21-5p, TNF-α, IL-6, macrophages, neutrophils, lymphocytes, Th17 cell proportion, and Th17/Treg than the AECOPD group, and had higher Foxp3, IL-10, SKP2 mRNA and protein expression, Treg cell proportion, PEF, PIF, and FEV0.3/FVC than the AECOPD group (P<0.05). In addition, miR-21-5p agomir reversed the protective effect of AP on AECOPD rats.
Conclusion AP improves lung function and immune imbalance in AECOPD rats by inhibiting the miR-21-5p/SKP2 pathway.
, authors=Ping FENG, Ze-xuan JI, Kai-yan SONG, Li-ping CHEN, Bu WANG, Hai-hong QIAN, Zhi-hua ZHANG, authorsList=Ping FENG, Ze-xuan JI, Kai-yan SONG, Li-ping CHEN, Bu WANG, Hai-hong QIAN, Zhi-hua ZHANG, authorCompany=null, correspAuthors=Zhi-hua ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707285940761576, articleId=1291707284766356454, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=苹果多酚调节
miR-21-5
p/SKP2通路对慢性阻塞性肺疾病急性加重期大鼠肺功能及免疫失衡的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨苹果多酚（AP）调节miR-21-5p/SKP2通路对慢性阻塞性肺疾病急性加重期（AECOPD）大鼠肺功能及免疫失衡的影响。
方法 通过香烟烟熏及滴注内毒素建立COPD稳定期，随后以鼻腔内滴注金黄色葡萄球菌菌液建立AECOPD大鼠，随机分为AECOPD组、AP-25组、AP-100组、地塞米松组、AP-100+NC agomir组、AP-100+miR-21-5p agomir组，并以生理盐水干预的大鼠为对照组，随后气管插管测量呼、吸气峰值流量（PEF、PIF）、0.3 s用力呼气容积与用力肺活量比值（FEV0.3/FVC）；收集血清检测肿瘤坏死因子α（TNF-α）、白细胞介素-6（IL-6）水平；回收支气管肺泡灌洗液（BALF），测定中性粒细胞、淋巴细胞及巨噬细胞数量；制备左肺叶切片，观察肺组织病变并评分；取大鼠右肺组织，检测肺组织中Th17、Treg细胞比例、miR-21-5p、SKP2 mRNA表达及维A酸相关孤儿受体γt（RORγt）、IL-17A、叉头框蛋白P3（Foxp3）、IL-10、SKP2蛋白表达。
结果 AECOPD组RORγt、IL-17A、miR-21-5p、TNF-α、IL-6、巨噬细胞、中性粒细胞、淋巴细胞数、Th17细胞比例、Th17/Treg较对照组增加，Foxp3、IL-10、SKP2 mRNA及蛋白表达、Treg细胞比例、PEF、PIF、FEV0.3/FVC较对照组降低（P<0.05）；AP-25组、AP-100组、地塞米松组RORγt、IL-17A、miR-21-5p、TNF-α、IL-6、巨噬细胞、中性粒细胞、淋巴细胞数、Th17细胞比例、Th17/Treg较AECOPD组降低，Foxp3、IL-10、SKP2 mRNA及蛋白表达、Treg细胞比例、PEF、PIF、FEV0.3/FVC较AECOPD组增加（P<0.05）；miR-21-5p agomir逆转了AP对AECOPD大鼠的保护作用。
结论 AP通过抑制miR-21-5p/SKP2通路改善AECOPD大鼠肺功能及免疫失衡。
, authors=冯平, 姬泽萱, 宋凯艳, 陈丽萍, 王布, 钱海红, 张志华, authorsList=冯平, 姬泽萱, 宋凯艳, 陈丽萍, 王布, 钱海红, 张志华, authorCompany=null, correspAuthors=张志华, authorNote=
冯平（1986-），女，主治医师，主要从事慢性气道疾病相关研究
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