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As a representative of the new generation of nucleic acid vaccine technology, messenger ribonucleic acid (mRNA) vaccines have demonstrated advantages such as rapid manufacture, high efficacy, and good safety since Coronavirus Disease 2019(COVID-19), becoming an important direction in global vaccine research and development. Many mRNA vaccines have been approved or in clinical trials. This article systematically reviews and summarizes the current research and development of mRNA vaccines, discussing the current state of mRNA vaccine development and evaluation strategies in China, with the aim of providing scientific basis for the development of mRNA vaccines.

, authors=Xia DENG, Shuang LU, authorsList=Xia DENG, Shuang LU, authorCompany=null, correspAuthors=Shuang LU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707201236788128, articleId=1291707200276292510, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=国内外mRNA疫苗临床研发进展和审评考虑, columnId=1291339025730760957, journalTitle=中国临床药理学杂志, columnName=药物评价与管理, runingTitle=null, highlight=null, articleAbstract=

信使核糖核酸（mRNA）疫苗作为新一代核酸疫苗技术的代表，自新型冠状病毒肺炎疫情以来展现出快速研发、高效保护和良好安全性等优势，成为全球疫苗研发的重要方向。全球已有多款mRNA疫苗获批上市或进入临床试验。本文系统梳理并总结了当前国内外mRNA疫苗的研发进展，讨论了我国mRNA疫苗的研发现状及审评策略，以期为mRNA疫苗的研发提供科学依据。

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邓霞（1987-），女，副研究员，主要从事疫苗临床专业审评相关工作

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邓霞（1987-），女，副研究员，主要从事疫苗临床专业审评相关工作

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