Article(id=1291707087122362640, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.22.018, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1759075200000, receivedDateStr=2025-09-29, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896568326, onlineDateStr=2026-08-05, pubDate=1764259200000, pubDateStr=2025-11-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896568326, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896568326, creator=13701087609, updateTime=1785896568326, updator=13701087609, issue=Issue{id=1291707004800750583, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='22', pageStart='3151', pageEnd='3300', issueExtLink='null', onlineDate='null', pubDate='1764259200000', pubDateStr='2025-11-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896548700, creator='13701087609', updateTime=1785896693213, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707610999316815, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707610999316816, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3270, endPage=3276, ext={EN=ArticleExt(id=1291707087386603793, articleId=1291707087122362640, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research progress on the role of remazolam in the prevention and treatment of perioperative neurocognitive disorders in elderly patients with hip fracture, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Elderly patients with hip fracture have a high incidence of perioperative neurocognitive disorders (PND), poor prognosis and high resource consumption. Remazolam has the pharmacokinetic advantages of esterase metabolism, predictable recovery and hemodynamic friendliness, and can be quickly reversed by flumazenil, making it suitable for people with advanced age, insufficient organ reserve or high risk of cognitive complications. Recent studies have shown that remazolam can reduce the level of postoperative inflammatory markers, improve early cognitive function and reduce the incidence of delirium, while retaining good hemodynamic stability and controllable recovery characteristics. The underlying mechanism involves the inhibition of excessive activation of microglia and neuroinflammatory response, reduction of systemic inflammatory response, reduction of stress and pain intensity, and reduction of cerebral hypoperfusion events and other pathways to produce neuroprotective effects. Therefore, this paper integrates the latest evidence of the molecular mechanism, pharmacological characteristics and clinical application of remazolam in the prevention and treatment of perioperative neurocognitive disorders in elderly patients with hip fracture, and emphasizes its potential value in optimizing perioperative anesthesia management of elderly hip fracture. It is expected to provide a theoretical basis for future high-quality, multi-center, long-term follow-up clinical research, and provide reference for individualized perioperative strategy formulation and PND prevention and treatment.

, authors=Ju-xian ZHAO, Shuan-jun ZHANG, Wen LI, Cai-hong WANG, Hui-wen WANG, authorsList=Ju-xian ZHAO, Shuan-jun ZHANG, Wen LI, Cai-hong WANG, Hui-wen WANG, authorCompany=null, correspAuthors=Hui-wen WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707087940251923, articleId=1291707087122362640, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=瑞马唑仑防治髋部骨折老年患者围术期神经认知障碍的作用研究进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

髋部骨折老年患者围术期神经认知障碍（PND）发生率高、预后差、资源消耗大。瑞马唑仑具有酯酶代谢、可预测苏醒及血流动力学友好等药代学优势，并可被氟马西尼快速逆转，使其适用于高龄、脏器储备不足或认知并发症高风险人群。近年研究显示，瑞马唑仑可降低术后炎症标志物水平、改善早期认知功能及减少谵妄发生率，同时保留了较好的血流动力学稳定性与可控苏醒特征。其潜在机制涉及抑制微胶质过度激活与神经炎症反应、减轻全身炎症反应、降低应激与疼痛强度以及减少脑低灌注事件等多通路产生神经保护效应。因此，本文整合了瑞马唑仑在防治髋部骨折老年患者围术期神经认知障碍的分子机制、药理特性与临床应用方面的最新证据，更强调其在优化老年髋部骨折围术期麻醉管理中的潜在价值。期望为未来高质量、多中心、长期随访的临床研究提供理论依据，并为个体化围术期策略制定及PND防治提供参考。

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赵炬仙（1986-），女，主治医师，主要从事临床麻醉与麻醉技术相关研究

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赵炬仙（1986-），女，主治医师，主要从事临床麻醉与麻醉技术相关研究

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