Article(id=1291707037910585619, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.22.017, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1753891200000, receivedDateStr=2025-07-31, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896556593, onlineDateStr=2026-08-05, pubDate=1764259200000, pubDateStr=2025-11-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896556593, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896556593, creator=13701087609, updateTime=1785896556593, updator=13701087609, issue=Issue{id=1291707004800750583, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='22', pageStart='3151', pageEnd='3300', issueExtLink='null', onlineDate='null', pubDate='1764259200000', pubDateStr='2025-11-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896548700, creator='13701087609', updateTime=1785896693213, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707610999316815, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707610999316816, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3262, endPage=3269, ext={EN=ArticleExt(id=1291707038183215380, articleId=1291707037910585619, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research advances on pharmacokinetic characteristics of cardiovascular drugs in high-altitude hypoxic environments, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

The high-altitude environment is characterized by hypoxia, low temperatures, strong radiation, and low humidity, with hypoxia exerting profound effects on human physiological functions. Cardiovascular disease, a prevalent chronic condition in plateau regions, poses a serious threat to health. While pharmacotherapy is the primary intervention, the hypoxic environment significantly alters the pharmacokinetic processes of cardiovascular drugs in vivo, thereby compromising their safety and efficacy. Consequently, investigating the pharmacokinetic characteristics of cardiovascular drugs under high-altitude hypoxia is crucial. Given the current scarcity of research in this area, this review summarizes the impact of high-altitude hypoxia on key pharmacokinetic parameters of cardiovascular drugs and explores potential mechanisms of action, aiming to provide a theoretical basis for the rational clinical use of these drugs in plateau areas.

, authors=Qin-qin MA^{1, 2, 4}, Rui ZHANG^{1, 2, 4}, Luo-bu GESANG^{1, 2, 3}, authorsList=Qin-qin MA, Rui ZHANG, Luo-bu GESANG, authorCompany=null, correspAuthors=Luo-bu GESANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707038602645781, articleId=1291707037910585619, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=高原低氧环境下心血管药物药代动力学特征的研究进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

高原环境以低氧、低温、高辐射和低湿度为特征，其中低氧对人体生理功能影响尤为显著。心血管疾病作为高原地区常见慢性病，严重威胁生命健康。目前药物治疗是其主要干预手段，但低氧环境会影响药物在体内的药代动力学过程，影响用药安全性与疗效。因此，研究高原低氧环境下心血管药物的药代动力学特征具有重要意义。鉴于当前相关研究尚不充分，本文综述了高原低氧对心血管药物关键药代动力学参数的影响及其潜在作用机制，旨在为高原地区心血管药物的合理应用提供理论依据。

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马琴琴（1995-），女，研究实习员，主要从事药代动力学相关的研究和工作

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马琴琴（1995-），女，研究实习员，主要从事药代动力学相关的研究和工作

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