Article(id=1291707168961618711, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.21.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1750953600000, receivedDateStr=2025-06-27, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896587838, onlineDateStr=2026-08-05, pubDate=1763308800000, pubDateStr=2025-11-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896587838, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896587838, creator=13701087609, updateTime=1785896587838, updator=13701087609, issue=Issue{id=1291706987964822180, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='21', pageStart='3001', pageEnd='3150', issueExtLink='null', onlineDate='null', pubDate='1763308800000', pubDateStr='2025-11-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896544684, creator='13701087609', updateTime=1785896721343, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707729324826977, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707729324826978, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3075, endPage=3082, ext={EN=ArticleExt(id=1291707169553015576, articleId=1291707168961618711, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research of geniposide on insulin resistance and oxidative stress damage in polycystic ovary syndrome rats by regulating the Nrf2/HO-1 signaling pathway, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the effects of geniposide on insulin resistance and oxidative stress damage in polycystic ovary syndrome (PCOS) rats by regulating the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1(HO-1) signaling pathway.
Methods A PCOS model was induced by gavage of letrozole for 21d and rats were randomly assigned into blank group (not modeled +normal saline), model group (modeled +normal saline), low-dose geniposide group (modeled+400 mg·kg-1 geniposide by gavage), high-dose geniposide group (modeled+800 mg·kg-1 geniposide by gavage), positive control group (modeled+0.34 mg·kg-1 ethinylestradiol and cyproterone by gavage) and high-dose geniposide+ML385 group (modeled+800 mg·kg-1 geniposide by gavage+30 mg·kg-1 ML385 by by intraperitoneal injection), with 10 rats in each group. The levels of fasting blood glucose (FBG) and fasting insulin (FINS) were measured by blood glucose meter and enzyme-linked immunosorbent assay (ELISA) and then homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. The levels of serum sex hormones and inflammatory were detected by ELISA and ovarian tissue oxidative stress index levels were detected by test kit, hematoxylin-eosin (HE) staining was used to measure the number of cystic follicles in rat ovarian tissue. TdT-media duTP nict end labeling (TUNEL) method was used to measure apoptosis of rat ovarian granulosa cells. Moreover, Western blot (WB) was used to detect apoptosis and Nrf2/HO-1 signaling pathway related protein expression in ovarian tissues.
Results The FBG levels in the low-dose geniposide group, high-dose geniposide group, positive control group, high-dose geniposide+ML385 group and control group, as well as the model group were (6.87±0.42), (5.21±0.28), (5.03±0.31), (8.32±0.51), (4.90±0.35) and (8.56±0.54) mmol·L-1, respectively; FINS were (16.13±1.62), (10.46±1.37), (10.21±1.51), (20.67±1.82), (9.82±1.14) and (21.45±2.05) mIU·L-1, respectively; HOMA-IR were 4.93±0.48、2.42±0.53、2.28±0.36、7.64±0.72、2.14±0.31 and 8.16±0.67, respectively; follicle-stimulating hormone (FSH) levels were (5.14±0.56), (7.49±0.62), (7.62±0.71), (2.95±0.54), (7.83±0.76) and (2.71±0.43) IU·L-1, respectively; the superoxide dismutase (SOD) levels were (42.91±3.22), (56.45±4.16), (58.02±3.98), (32.16±2.85), (59.73±4.35) and (30.84±2.74) U·mg prot-1, respectively. The relative protein expression levels of Nrf2 were 0.67±0.08, 1.10±0.12, 1.12±0.13, 0.26±0.07, 1.13±0.14 and 0.24±0.06, respectively; HO-1 were 0.61±0.07, 1.06±0.08, 1.08±0.10, 0.18±0.05, 1.09±0.11 and 0.16±0.04, respectively. The malondialdehyde (MDA) levels were (2.47±0.33), (1.39±0.21), (1.30±0.19), (3.38±0.42), (1.21±0.26) and (3.62±0.47) nmol·mg prot-1, respectively. The number of ovarian antral follicles was 9.60±0.74, 4.30±0.57, 4.10±0.71, 14.20±0.98, 3.90±0.65 and 15.10±1.13, respectively. The ovarian granulosa cell apoptosis index was (16.27±1.16)%, (7.48±0.91)%, (7.19±0.76)%, (23.86±1.23)%, (6.94±0.85)% and (25.31±1.42)%, respectively. Compared blank group with the control group; compared model group with low-dose geniposide group, high-dose geniposide group and positive control group; compared low-dose geniposide group with high-dose geniposide group and compred high-dose geniposide group with high-dose geniposide+ML385 group, the differences of above indexes were all statistically significant (all P<0.05).
Conclusion Geniposide can alleviate insulin resistance and oxidative stress damage in PCOS rats, possibly by activating the Nrf2/HO-1 signaling pathway.
, authors=Qing-lian MA
1, Qin TIAN
1, Yan ZHANG
2, Jing YANG
3, authorsList=Qing-lian MA, Qin TIAN, Yan ZHANG, Jing YANG, authorCompany=null, correspAuthors=Jing YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707169917920025, articleId=1291707168961618711, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=栀子苷调节Nrf2/HO-1信号通路对多囊卵巢综合征大鼠胰岛素抵抗及氧化应激损伤的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 研究栀子苷调节核因子红细胞系2相关因子2（Nrf2）/血红素加氧酶-1（HO-1）信号通路对多囊卵巢综合征（PCOS）大鼠胰岛素抵抗及氧化应激损伤的影响。
方法 SD大鼠通过灌胃来曲唑21 d来诱导建立PCOS模型，并随机分为空白组（不建模+生理盐水）、模型组（建模+生理盐水）、栀子苷低剂量实验组（建模+灌胃给予400 mg·kg-1栀子苷）、栀子苷高剂量实验组（建模+灌胃给与800 mg·kg-1栀子苷）、阳性对照组（建模+灌胃给予0.34 mg·kg-1炔雌醇环丙孕酮）、栀子苷高剂量+ML385组（建模+灌胃给与800 mg·kg-1栀子苷+腹腔注射30 mg·kg-1 ML385），每组10只。用血糖仪、酶联免疫吸附法分别检测大鼠空腹血糖（FBG）和空腹胰岛素（FINS）水平，并计算胰岛素抵抗指数（HOMA-IR）；用酶联免疫吸附法测定血清性激素与炎性水平，用试剂盒法检测卵巢组织氧化应激指标水平；用苏木精-伊红（HE）染色法检测大鼠卵巢组织囊状卵泡数量；用原位末端标记法（TUNEL）检测大鼠卵巢颗粒细胞凋亡；用蛋白质印迹法（WB）检测各组大鼠卵巢组织凋亡和Nrf2/HO-1信号通路相关蛋白相对表达水平。
结果 栀子苷低、高剂量实验组、阳性对照组、栀子苷高剂量+ML385组、空白组和模型组的FBG分别为（6.87±0.42）、（5.21±0.28）、（5.03±0.31）、（8.32±0.51）、（4.90±0.35）和（8.56±0.54）mmol·L-1；FINS分别为（16.13±1.62）、（10.46±1.37）、（10.21±1.51）、（20.67±1.82）、（9.82±1.14）和（21.45±2.05）mIU·L-1；HOMA-IR分别为4.93±0.48、2.42±0.53、2.28±0.36、7.64±0.72、2.14±0.31和8.16±0.67，促卵泡激素（FSH）水平分别为（5.14±0.56）、（7.49±0.62）、（7.62±0.71）、（2.95±0.54）、（7.83±0.76）和（2.71±0.43）IU·L-1；超氧化物歧化酶（SOD）分别为（42.91±3.22）、（56.45±4.16）、（58.02±3.98）、（32.16±2.85）、（59.73±4.35）和（30.84±2.74）U·mg prot-1；Nrf2蛋白相对表达水平分别为0.67±0.08、1.10±0.12、1.12±0.13、0.26±0.07、1.13±0.14和0.24±0.06；HO-1蛋白相对表达水平分别为0.61±0.07、1.06±0.08、1.08±0.10、0.18±0.05、1.09±0.11和0.16±0.04；丙二醛（MDA）水平分别为（2.47±0.33）、（1.39±0.21）、（1.30±0.19）、（3.38±0.42）、（1.21±0.26）和（3.62±0.47）nmol·mg prot-1；卵巢囊状卵泡数量分别为（9.60±0.74）、（4.30±0.57）、（4.10±0.71）、（14.20±0.98）、（3.90±0.65）和（15.10±1.13）个；卵巢颗粒细胞凋亡指数分别为（16.27±1.16）%、（7.48±0.91）%、（7.19±0.76）%、（23.86±1.23）%、（6.94±0.85）%和（25.31±1.42）%，模型组的上述指标与空白组比较；栀子苷低、高剂量实验组及阳性对照组的上述指标与模型组比较，栀子苷低剂量实验组的上述指标与栀子苷高剂量试验组比较，栀子苷高剂量+ML385组与栀子苷高剂量实验组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 栀子苷可减轻PCOS大鼠胰岛素抵抗及氧化应激损伤，可能是通过激活Nrf2/HO-1信号通路实现的。
, authors=马卿莲
1, 田琴
1, 张艳
2, 杨菁
3, authorsList=马卿莲, 田琴, 张艳, 杨菁, authorCompany=null, correspAuthors=杨菁, authorNote=
马卿莲（1978-），女，副主任医师，主要从事妇科内分泌相关的研究和工作
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=21qoZuNfV21G7BKOYj+Euw==, magXml=t/otO/gTXdHABu/y0YeKbQ==, pdfUrl=null, pdf=6gyegUONnxxyHvHcea2zzQ==, pdfFileSize=1635520, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=3k+w65sFx62bVlYT/xvyKg==, mapNumber=null, fund=null)}, authors=[Author(id=1291707172983956260, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291707173269168934, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, authorId=1291707172983956260, language=EN, stringName=Qing-lian MA, firstName=Qing-lian, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.Department of Obstetrics and Gynecology, Wuhan Red Cross Hospital, Wuhan 430000, Hubei Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291707173579547431, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, authorId=1291707172983956260, language=CN, stringName=马卿莲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.武汉市红十字会医院 妇产科，湖北 武汉 430000, bio={"content":"
马卿莲（1978-），女，副主任医师，主要从事妇科内分泌相关的研究和工作
"}, bioImg=null, bioContent=
马卿莲（1978-），女，副主任医师，主要从事妇科内分泌相关的研究和工作
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291707172040237850, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, xref=1., ext=[AuthorCompanyExt(id=1291707172044432155, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172040237850, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Department of Obstetrics and Gynecology, Wuhan Red Cross Hospital, Wuhan 430000, Hubei Province, China), AuthorCompanyExt(id=1291707172057015068, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172040237850, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.武汉市红十字会医院 妇产科，湖北 武汉 430000)])]), Author(id=1291707173843788585, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291707174191915819, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, authorId=1291707173843788585, language=EN, stringName=Qin TIAN, firstName=Qin, middleName=null, lastName=TIAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.Department of Obstetrics and Gynecology, Wuhan Red Cross Hospital, Wuhan 430000, Hubei Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291707174384853804, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, authorId=1291707173843788585, language=CN, stringName=田琴, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.武汉市红十字会医院 妇产科，湖北 武汉 430000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291707172040237850, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, xref=1., ext=[AuthorCompanyExt(id=1291707172044432155, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172040237850, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Department of Obstetrics and Gynecology, Wuhan Red Cross Hospital, Wuhan 430000, Hubei Province, China), AuthorCompanyExt(id=1291707172057015068, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172040237850, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.武汉市红十字会医院 妇产科，湖北 武汉 430000)])]), Author(id=1291707176159044398, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291707176519754544, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, authorId=1291707176159044398, language=EN, stringName=Yan ZHANG, firstName=Yan, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2.Department of Laboratory Medicine, Wuhan University People’s Hospital, Wuhan 430029, Hubei Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291707176788190001, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, authorId=1291707176159044398, language=CN, stringName=张艳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2.武汉大学 人民医院 检验科，湖北 武汉 430029, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291707172254147357, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, xref=2., ext=[AuthorCompanyExt(id=1291707172266730270, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172254147357, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Department of Laboratory Medicine, Wuhan University People’s Hospital, Wuhan 430029, Hubei Province, China), AuthorCompanyExt(id=1291707172279313183, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172254147357, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.武汉大学 人民医院 检验科，湖北 武汉 430029)])]), Author(id=1291707177115345715, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=dryangqing@hotmail.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291707177367003957, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, authorId=1291707177115345715, language=EN, stringName=Jing YANG, firstName=Jing, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.Reproductive Medicine Center, People’s Hospital of Wuhan University, Wuhan 430029, Hubei Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291707177505415990, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, authorId=1291707177115345715, language=CN, stringName=杨菁, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.武汉大学 人民医院 生殖医学中心，湖北 武汉 430029, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291707172614857504, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, xref=3., ext=[AuthorCompanyExt(id=1291707172623246113, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172614857504, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.Reproductive Medicine Center, People’s Hospital of Wuhan University, Wuhan 430029, Hubei Province, China), AuthorCompanyExt(id=1291707172627440418, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172614857504, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.武汉大学 人民医院 生殖医学中心，湖北 武汉 430029)])])], keywords=[Keyword(id=1291707177635439415, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, language=EN, orderNo=1, keyword=geniposide), Keyword(id=1291707177731908408, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, language=EN, orderNo=2, keyword=nuclear factor E2-related factor 2/ heme oxygenase-1), Keyword(id=1291707177840960313, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, language=EN, orderNo=3, keyword=polycystic ovary syndrome), Keyword(id=1291707177937429306, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, language=EN, orderNo=4, keyword=insulin resistance), Keyword(id=1291707178033898299, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, language=EN, orderNo=5, keyword=oxidative stress), Keyword(id=1291707178239419196, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, language=CN, orderNo=1, keyword=栀子苷), Keyword(id=1291707178314916669, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, language=CN, orderNo=2, keyword=核因子红细胞系2相关因子2/血红素加氧酶-1), Keyword(id=1291707178402997054, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, language=CN, orderNo=3, keyword=多囊卵巢综合征), Keyword(id=1291707178499466047, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, language=CN, orderNo=4, keyword=胰岛素抵抗), Keyword(id=1291707178684015424, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, language=CN, orderNo=5, keyword=氧化应激)], refs=null, funds=[Fund(id=1291707178855981889, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, awardId=WJ2019F017, language=CN, fundingSource=湖北省卫生健康委员会科研基金资助项目(WJ2019F017), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1291707172040237850, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, xref=1., ext=[AuthorCompanyExt(id=1291707172044432155, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172040237850, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Department of Obstetrics and Gynecology, Wuhan Red Cross Hospital, Wuhan 430000, Hubei Province, China), AuthorCompanyExt(id=1291707172057015068, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172040237850, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.武汉市红十字会医院 妇产科，湖北 武汉 430000)]), AuthorCompany(id=1291707172254147357, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, xref=2., ext=[AuthorCompanyExt(id=1291707172266730270, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172254147357, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Department of Laboratory Medicine, Wuhan University People’s Hospital, Wuhan 430029, Hubei Province, China), AuthorCompanyExt(id=1291707172279313183, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172254147357, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.武汉大学 人民医院 检验科，湖北 武汉 430029)]), AuthorCompany(id=1291707172614857504, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, xref=3., ext=[AuthorCompanyExt(id=1291707172623246113, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172614857504, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.Reproductive Medicine Center, People’s Hospital of Wuhan University, Wuhan 430029, Hubei Province, China), AuthorCompanyExt(id=1291707172627440418, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707168961618711, companyId=1291707172614857504, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.武汉大学 人民医院 生殖医学中心，湖北 武汉 430029)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1788948995538, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509895005466898, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995591, updatedTime=1788948995591, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1304509895047409939, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995601, updatedTime=1788948995601, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.21.013, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.21.013, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.21.013, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.21.013, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1763308800000, fullTextJson=null, articleText=null, reference=null)
PDF下载
全屏
138
26
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
