Article(id=1291707021808652448, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.21.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1752508800000, receivedDateStr=2025-07-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896552754, onlineDateStr=2026-08-05, pubDate=1763308800000, pubDateStr=2025-11-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896552754, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896552754, creator=13701087609, updateTime=1785896552754, updator=13701087609, issue=Issue{id=1291706987964822180, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='21', pageStart='3001', pageEnd='3150', issueExtLink='null', onlineDate='null', pubDate='1763308800000', pubDateStr='2025-11-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896544684, creator='13701087609', updateTime=1785896721343, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707729324826977, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707729324826978, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3061, endPage=3066, ext={EN=ArticleExt(id=1291707022026756257, articleId=1291707021808652448, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research of quercetin alleviating lipopolysaccharide induced acute renal injury based on Nrf2/IκB-α/NF-κB signaling axis, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective Based on the nuclear factor E2-related factor 2 (Nrf2)/nuclear factor kappa B inhibitor alpha (IκB-α)/nuclear factor-kappa B (NF-κB) signaling axis, this study explored the protective effects of quercetin on lipopolysaccharide (LPS)-induced acute kidney injury (AKI) in rats.
Methods A total of 60 SD rats were randomly divided into control group, model group, dexamethasone (DEX) group, quercetin high dose (100 mg·kg-1) experimental group and quercetin low (10 mg·kg-1) dose experimental group, with 12 rats in each group. Except for the control group, all other groups received intraperitoneal injection of LPS (10 mg·kg-1) to prepare an AKI rat model. Enzyme-linked immunosorbent assay was used to detect serum levels of cystatin C (CysC), kidney injury molecule-1 (KIM-1) and inflammatory factors; renal tissue pathological changes were observed, and levels of myeloperoxidase (MPO), catalase (CAT) and 4-hydroxynonenal (4-HNE) in renal tissues were measured by colorimetry; immunohistochemistry was used to detect protein relative expression levels of Nrf2, IκB-α and NF-κB.
Results The levels of CysC in control group, model group, quercetin high dose group, low dose group and DEX group were (93.18±8.29), (317.58±12.26), (132.73±10.52), (182.91±10.63) and (153.29±10.14) ng·mL-1, respectively; levels of KIM-1 were (12.39±1.79), (52.19±4.26), (26.83±3.89), (35.71±4.03) and (29.07±4.12) pg·mL-1, respectively; MPO were (72.52±8.23), (177.95±9.14), (116.37±8.93), (136.52±9.37) and (121.81±9.02) pg·mL-1, respectively; CAT contents were (60.73±8.12), (17.92±8.32), (38.41±8.73), (29.72±7.95) and (36.68±9.26) U·mL-1, respectively; 4-HNE were (59.82±7.38), (179.63±9.41), (97.38±8.83), (116.91±9.17) and (98.56±8.79) nmol·L-1, respectively. The levels of tumor necrosis factor-α (TNF-α) were (8.96±2.69), (58.27±5.13), (19.14±4.82), (39.56±5.37) and (16.38±4.11) pg·mL-1, respectively; IL-1β were (15.62±3.58), (52.09±5.76), (29.47±4.61), (36.17±5.23) and (25.76±4.29) pg·mL-1, respectively; IL-6 were (10.46±2.89), (71.14±6.53), (21.93±5.57), (33.28±5.96) and (19.12±5.61) pg·mL-1, respectively. The intergrated optical density (IOD) of Nrf2 protein were 92.56±6.13, 45.09±6.97, 73.22±6.02, 63.52±6.73 and 68.29±6.51; IκB-α protein IOD values were 85.62±5.75, 42.83±6.29, 70.12±6.51, 61.45±6.87 and 78.77±6.32; the IOD values of NF-κB p65 protein were 43.28±4.92, 87.59±6.35, 55.79±5.32, 68.83±6.13 and 49.18±5.08, respectively. There were significant differences in the above indexes between the control group and the model group, between the model group and the quercetin high and low dose groups, and the DEX group (all P<0.05).
Conclusion Quercetin may alleviate inflammation and oxidative stress damage by regulating the expression of Nrf2/IκB-α/NF-κB signaling axis, thereby playing a protective role against LPS-induced acute kidney injury.
, authors=Hao-ruo YANG
1, Jian-long XU
2, Yu ZHANG
2, Bin YANG
2, authorsList=Hao-ruo YANG, Jian-long XU, Yu ZHANG, Bin YANG, authorCompany=null, correspAuthors=Bin YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707022358106274, articleId=1291707021808652448, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于Nrf2/IκB-α/NF-κB信号轴探讨槲皮素减轻脂多糖诱导急性肾损伤的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 基于核因子E2相关因子2（Nrf2）/核因子κB抑制蛋白α（IκB-α）/核转录因子-κB（NF-κB）信号轴探讨槲皮素对脂多糖（LPS）诱导急性肾损伤（AKI）大鼠的保护作用。
方法 60只SD大鼠随机分为对照组、模型组、阳性对照组（地塞米松，dexamethasone）和槲皮素高、低（100、10 mg·kg-1）剂量实验组，每组12只。除对照组外各组腹腔注射10 mg·kg-1脂多糖（LPS）制备急性肾损伤大鼠模型。用酶联免疫吸附法检测血清胱抑素（CysC）、肾损伤分子-1（KIM-1）及炎症因子水平；用比色法检测肾组织髓过氧化酶（MPO）、过氧化氢酶（CAT）和四羟基壬二醛（4-HNE）水平；用免疫组化法检测Nrf2、IκB-α和NF-κB蛋白相对表达水平。
结果 对照组、模型组、槲皮素高、低剂量实验组和阳性对照组的CysC水平分别为（93.18±8.29）、（317.58±12.26）、（132.73±10.52）、（182.91±10.63）和（153.29±10.14）ng·mL-1；KIM-1分别为（12.39±1.79）、（52.19±4.26）、（26.83±3.89）、（35.71±4.03）和（29.07±4.12）pg·mL-1；MPO含量分别为（72.52±8.23）、（177.95±9.14）、（116.37±8.93）、（136.52±9.37）和（121.81±9.02）pg·mL-1；CAT含量分别为（60.73±8.12）、（17.92±8.32）、（38.41±8.73）、（29.72±7.95）和（36.68±9.26）U·mL-1；4-HNE分别为（59.82±7.38）、（179.63±9.41）、（97.38±8.83）、（116.91±9.17）和（98.56±8.79）nmol·L-1。对照组、模型组、槲皮素高、低剂量实验组和阳性对照组的TNF-α水平分别为（8.96±2.69）、（58.27±5.13）、（19.14±4.82）、（39.56±5.37）和（16.38±4.11）pg·mL-1；IL-1β水平分别为（15.62±3.58）、（52.09±5.76）、（29.47±4.61）、（36.17±5.23）和（25.76±4.29）pg·mL-1；IL-6水平分别为（10.46±2.89）、（71.14±6.53）、（21.93±5.57）、（33.28±5.96）和（19.12±5.61）pg·mL-1；Nrf2蛋白相对表达水平分别为92.56±6.13、45.09±6.97、73.22±6.02、63.52±6.73和68.29±6.51；IκB-α蛋白相对表达水平分别为85.62±5.75、42.83±6.29、70.12±6.51、61.45±6.87和78.77±6.32；NF-κB p65蛋白相对表达水平分别为43.28±4.92、87.59±6.35、55.79±5.32、68.83±6.13和49.18±5.08。对照组上述指标与模型组比较，模型组的上述指标与高、低剂量实验组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 槲皮素可能通过调节Nrf2/IκB-α/NF-κB信号轴表达，减轻炎症及氧化应激损伤，发挥对LPS诱导急性肾损伤的保护作用。
, authors=杨昊若
1, 徐建龙
2, 张昱
2, 杨斌
2, authorsList=杨昊若, 徐建龙, 张昱, 杨斌, authorCompany=null, correspAuthors=杨斌, authorNote=
杨昊若（2002-），男，硕士研究生，主要从事中西医结合临床医学及中药药理学研究
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