Article(id=1291707191610860398, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.21.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1756396800000, receivedDateStr=2025-08-29, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896593238, onlineDateStr=2026-08-05, pubDate=1763308800000, pubDateStr=2025-11-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896593238, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896593238, creator=13701087609, updateTime=1785896593238, updator=13701087609, issue=Issue{id=1291706987964822180, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='21', pageStart='3001', pageEnd='3150', issueExtLink='null', onlineDate='null', pubDate='1763308800000', pubDateStr='2025-11-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896544684, creator='13701087609', updateTime=1785896721343, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707729324826977, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707729324826978, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3001, endPage=3006, ext={EN=ArticleExt(id=1291707192026096495, articleId=1291707191610860398, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Detection and antimicrobial resistance distribution of
Acinetobacter baumannii complex in a grade A tertiary hospital in Beijing (2017-2024), columnId=1291404846742102089, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Bacterial Resistance Surveillance, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the species distribution and antimicrobial resistance profiles of Acinetobacter baumannii complex (ABC) isolates from a Grade A tertiary hospital in Beijing (2017-2024), providing evidence for clinical microbiological identification and antimicrobial therapy.
Methods ABC isolates were collected from the hospital’s antimicrobial resistance surveillance network. Species identification was performed by mass sectrometry and susceptibility testing was analyzed using WHONET 5.6. Statistical comparisons of resistance rates were performed with SPSS 26.0 (chi-square test).
Results Among 2 752 non-repetitive ABC isolates,Acinetobacter baumannii (ABA) accounted for 91.75%, followed by Acinetobacter pittii (APT, 6.90%) and Acinetobacter nosocomialis (ANO, 1.31%). Sputum and urine were the predominant specimen types, with ABA and APT frequently isolated from bloodstream infections. The resistance profile varied statistically significantly defferences across the bacterial species for all 12 common antimicrobials (all P<0.05). Among these, ABA demonstrated the highest resistance rates, ANO showed an intermediate profile, and APT was the most susceptible. Specifically, ABA exhibited resistance rates exceeding 80% to β-lactam antibiotics, including piperacillin/tazobactam, ceftazidime, imipenem and meropenem. In contrast, ANO showed resistance rates of 30%-50%, and APT only 10%-30% to the same agents. Resistance profiles between ABA and ANO differed statistically significantly except for trimethoprim-sulfamethoxazole and minocycline (all P>0.05). The single Acinetobacter calcoaceticus isolate was only resistant to doxycycline and trimethoprim-sulfamethoxazole, while remaining susceptible to all other β-lactam and fluoroquinolone agents tested.
Conclusion ABC species exhibit distinct clinical distributions and resistance patterns, emphasizing the need for accurate species identification and ongoing resistance surveillance to guide appropriate empirical therapy.
, authors=Chang-yu XIA, Jia ZHOU, Ru-li FENG, Yan YAN, Lei HUANG, authorsList=Chang-yu XIA, Jia ZHOU, Ru-li FENG, Yan YAN, Lei HUANG, authorCompany=null, correspAuthors=Lei HUANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707192411972464, articleId=1291707191610860398, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=2017-2024年北京市某三甲医院鲍曼不动杆菌复合群的检出情况和耐药分布, columnId=1291404846905679947, journalTitle=中国临床药理学杂志, columnName=细菌耐药监测, runingTitle=null, highlight=null, articleAbstract=
目的 分析2017-2024年北京市某三甲医院鲍曼不动杆菌复合群（Acinetobacter baumannii complex，ABC）的菌种分布特征及耐药性差异，为临床微生物精准鉴定和抗菌药物合理使用提供科学依据。
方法 基于本院细菌耐药监测网数据，收集ABC复合群菌株的耐药监测资料。用质谱仪对菌种进行精确鉴定，用WHONET 5.6软件分析菌种的药敏结果，组间耐药率比较用SPSS 26.0进行卡方检验。
结果 共纳入首次分离的ABC菌株2 752株，其中鲍曼不动杆菌（ABA）占91.75%，皮特不动杆菌（APT）占6.90%，医院不动杆菌（ANO）占1.31%，另检出醋酸钙不动杆菌1株。痰液和尿液为最主要的标本来源，ABA和APT所致血流感染亦较常见。药敏结果显示：各菌种对12种常用抗菌药物的耐药率差异均具有统计学意义（均P<0.05）。ABA耐药率最高，ANO次之，APT敏感性最佳。ABA对β-内酰胺类抗菌药物，如哌拉西林/他唑巴坦、头孢他啶、亚胺培南和美罗培南的耐药率均超过80%；而ANO对上述药物的耐药率为30%～50%，APT仅为10%～30%。ABA与ANO对复方新诺明和米诺环素的耐药率比较，在统计学上差异均无统计学意义（均P>0.05）。醋酸钙不动杆菌仅对多西环素和复方新诺明耐药，而对β-内酰胺类和氟喹诺酮类均敏感。
结论 ABC不同菌种在标本分布、分离科室及耐药谱方面存在显著异质性，建议微生物实验室加强菌种精准鉴定与耐药性动态监测，为临床抗感染治疗提供精准指导。
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夏昌宇（1981-），女，主管技师，主要从事多重耐药菌感染机制与防控相关的研究
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