Article(id=1291704817005646213, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.20.017, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1752508800000, receivedDateStr=2025-07-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896027088, onlineDateStr=2026-08-05, pubDate=1761580800000, pubDateStr=2025-10-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896027088, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896027088, creator=13701087609, updateTime=1785896027088, updator=13701087609, issue=Issue{id=1291704786705993936, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='20', pageStart='2851', pageEnd='3000', issueExtLink='null', onlineDate='null', pubDate='1761580800000', pubDateStr='2025-10-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896019864, creator='13701087609', updateTime=1785896741492, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707813508702571, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707813508702572, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2948, endPage=2954, ext={EN=ArticleExt(id=1291704817282470278, articleId=1291704817005646213, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research progress on the treatment of polycystic ovary syndrome with traditional Chinese medicine by regulating the PI3K/Akt signaling pathway, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Polycystic ovary syndrome (PCOS) is a common reproductive and endocrine metabolic disorder in women of childbearing age. Its pathological mechanisms are complex and diverse, involving insulin resistance, hyperandrogenemia, oxidative stress damage, and disorders of glucose and lipid metabolism. Studies have found that the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway is involved in regulating the apoptosis and autophagy of ovarian granulosa cells (GCs). Traditional Chinese medicine precisely regulates the expression of proteins related to the PI3K/Akt pathway through multiple components and multiple targets, inhibits abnormal apoptosis and excessive autophagy of GCs, thereby significantly improving ovarian function and metabolic disorders, alleviating clinical symptoms of PCOS patients and delaying disease progression. This review explores the regulatory role of the PI3K/Akt signaling pathway in PCOS and analyzes the potential mechanisms of targeted intervention of PCOS by traditional Chinese medicine. Through a comprehensive analysis of existing literature, the research progress of traditional Chinese medicine monomers and their compound preparations in improving clinical symptoms of PCOS is summarized, aiming to provide scientific theoretical support for the rational clinical application of traditional Chinese medicine in the prevention and treatment of PCOS and to provide new research ideas for the development of new therapeutic drugs.

, authors=Qin SU¹, Li WANG², Rong-rong PAN¹, Ao ZHOU¹, Shao-min LU², Dong-peng ZHANG², Yu-jing HE¹, authorsList=Qin SU, Li WANG, Rong-rong PAN, Ao ZHOU, Shao-min LU, Dong-peng ZHANG, Yu-jing HE, authorCompany=null, correspAuthors=Shao-min LU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704817731260807, articleId=1291704817005646213, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中医药调控PI3K/Akt信号通路治疗多囊卵巢综合征研究进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

多囊卵巢综合征（PCOS）是育龄期女性常见的生殖和内分泌代谢性疾病，其病理机制复杂多样，涉及胰岛素抵抗、高雄激素血症、氧化应激损伤及糖脂代谢紊乱等。研究发现，磷脂酰肌醇3-激酶/蛋白激酶B（PI3K/Akt）信号通路参与调控卵巢颗粒细胞（GCs）的凋亡与自噬过程。中医药通过多成分、多靶点精准调控PI3K/Akt通路相关蛋白表达水平，有效抑制GCs异常凋亡与过度自噬，从而显著改善卵巢功能和代谢紊乱，从而有效缓解PCOS患者的临床症状并延缓疾病的进展。本综述探讨PI3K/Akt信号通路在PCOS中的调控作用，并分析中医药对靶向干预PCOS的潜在机制。通过对现有文献的综合分析，总结了中药单体及其复方制剂在改善PCOS临床症状方面的研究进展，旨在为临床合理应用中医药防治PCOS提供科学的理论支持，为开发新型治疗药物提供新的研究思路。

, authors=苏琴¹, 王黎², 潘蓉蓉¹, 周澳¹, 芦少敏², 张东鹏², 何玉晶¹, authorsList=苏琴, 王黎, 潘蓉蓉, 周澳, 芦少敏, 张东鹏, 何玉晶, authorCompany=null, correspAuthors=芦少敏, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=8pnq3Gjp2uGYPwgi32oXMA==, magXml=1w+tq+A8N76QQ/mkr5n7iA==, pdfUrl=null, pdf=ds16O2gkmi/hQxzjt0vHsg==, pdfFileSize=1531673, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=Mq33ETJ02d/bzt6hpVZHVg==, mapNumber=null, fund=null)}, authors=[Author(id=1292440036893549410, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704817005646213, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292440036973241188, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704817005646213, authorId=1292440036893549410, language=EN, stringName=Qin SU, firstName=Qin, middleName=null, lastName=SU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.College of Integrated Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292440037044544357, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704817005646213, authorId=1292440036893549410, language=CN, stringName=苏琴, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.甘肃中医药大学，中西医结合学院，甘肃 兰州 730000, bio={"content":"

苏琴（1999-），女，硕士研究生，主要从事中西医结合防治内分泌疾病的工作和研究

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苏琴（1999-），女，硕士研究生，主要从事中西医结合防治内分泌疾病的工作和研究

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