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Article(id=1291704844939718872, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.20.015, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1752508800000, receivedDateStr=2025-07-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896033749, onlineDateStr=2026-08-05, pubDate=1761580800000, pubDateStr=2025-10-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896033749, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896033749, creator=13701087609, updateTime=1785896033749, updator=13701087609, issue=Issue{id=1291704786705993936, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='20', pageStart='2851', pageEnd='3000', issueExtLink='null', onlineDate='null', pubDate='1761580800000', pubDateStr='2025-10-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896019864, creator='13701087609', updateTime=1785896741492, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707813508702571, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707813508702572, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2934, endPage=2940, ext={EN=ArticleExt(id=1291704845359149273, articleId=1291704844939718872, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Literature analysis of clinical characteristics of hypersensitivity reactions induced by etoposide, columnId=1246531412438966969, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Reader’s Field, runingTitle=null, highlight=null, articleAbstract=
Objective

To collect the case reports of hypersensitivity reactions induced by etoposide and systematically summarize the characteristics, clinical manifestations, and treatment outcomes of hypersensitivity reactions, in order to provide corresponding reference for the safe use of etoposide.

Methods

The related case reports of hypersensitivity reactions induced by etoposide were retrieved and collected from databases such as China National Knowledge Infrastructure China Hospital Knowledge Base, Wanfang, VIP, Pubmed and Web of Science, and basic information such as patient gender, age, medication use, time of hypersensitivity reaction occurrence, and treatment outcomes was statistically analyzed as well.

Results

A total of 27 case reports were finally included, involving 34 patients which included 21 males and 12 females and 1 patient whose gender was not mentioned. The average age of the patients was (45.83±15.50) years, with approximately 60% being over 40 years old. The majority of included cases were lung cancer patients, and the occurrence time of hypersensitivity reactions induced by etoposide was relatively short, with 18 patients experiencing hypersensitivity reactions within 1-10 minutes of medication, while only 3 patients had hypersensitivity reactions that occurred for more than 1 hour. Hypersensitivity reactions could affect many systems of the body, such as respiratory, circulatory, skin and its appendages. Common clinical manifestations of hypersensitivity reactions included difficulty breathing, chest tightness, papules, palpitations, hypotension, cyanosis; in addition, there were many serious cases such as anaphylactic shock. All cases showed improvement after treatment, and the patient did not experience any hypersensitivity reactions after receiving another infusion of etoposide, which had been pre treated with hormones or anti allergic drugs.

Conclusion

Hypersensitivity reactions induced by etoposide belong to immediate hypersensitivity reactions, characterized by short onset time, rapid progression, and good prognosis. In clinical practice, it is necessary to closely observe the status of patients during infusion of etoposide, strengthen medication monitoring, which can ensure the safety use of etoposide.

, authors=Dong CHI1, Chun-xing WU2, Han-meng DING3, Qing-jie SHI4, Peng-hui LIU5, authorsList=Dong CHI, Chun-xing WU, Han-meng DING, Qing-jie SHI, Peng-hui LIU, authorCompany=null, correspAuthors=Peng-hui LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704847368220890, articleId=1291704844939718872, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=依托泊苷致过敏反应临床特点的文献分析, columnId=1246531414020219657, journalTitle=中国临床药理学杂志, columnName=读者园地, runingTitle=null, highlight=null, articleAbstract=
目的

收集依托泊苷致过敏反应的个案报道并系统总结过敏反应发生的特点、临床表现及治疗转归等，以期为依托泊苷的安全使用提供参考。

方法

以中国知网中国医院知识库、万方医学网、维普网、Pubmed以及Web of Science等数据库为来源，检索收集依托泊苷致过敏反应的病例报道，并统计分析患者性别、年龄、用药情况、过敏反应发生时间以及处置转归等基本信息。

结果

共纳入27篇个案报道，涉及34例患者，其中男性21例，女性12例，还有一名患者性别未提及。患者平均年龄（45.83±15.50）岁，40岁以上占比约为60%。纳入的病例以肺癌患者居多，依托泊苷致过敏反应的发生时间较为短暂，有18例患者在用药的1~10 min内即出现了过敏反应，仅3例患者过敏反应的发生时间在1 h以上。过敏反应可累及呼吸、循环和皮肤及其附件等系统，并以呼吸困难、胸闷、丘疹、心慌、低血压、发绀等为常见临床表现，且不乏过敏性休克等严重病例。所有病例经干预后均好转，而经激素或抗过敏药等处理后，患者再次输注依托泊苷则未再出现过敏反应。

结论

依托泊苷所致过敏反应属速发型超敏反应，具有发生时间短暂、进展迅速、预后良好等特点；临床实际中应密切观察患者在输注依托泊苷时的状态，加强用药监护，确保依托泊苷使用的安全性。

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迟栋（1984-），男，副教授，主要从事抗肿瘤成分分离筛选相关工作

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刘鹏辉，副教授 MP: 19939790284 E-mail:
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依托泊苷致过敏反应临床特点的文献分析
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迟栋 1 , 吴春兴 2 , 丁韩梦 3 , 师卿杰 4 , 刘鹏辉 5
中国临床药理学杂志 | 读者园地 2025,41(20): 2934-2940
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中国临床药理学杂志 |读者园地 2025 , 41 (20) : 2934 -2940
依托泊苷致过敏反应临床特点的文献分析
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迟栋1, 吴春兴2, 丁韩梦3, 师卿杰4, 刘鹏辉5
作者信息
  • 1.南阳医学高等专科学校 河南 南阳 473000
  • 2.滨州市中心医院，山东 滨州 251700
  • 3.邓州市中国人民解放军95977部队，北京 100076
  • 4.河南中医药大学 第三附属医院，河南 郑州 450003
  • 5.防城港职业技术学院，广西 防城港 538000
通讯作者:
刘鹏辉，副教授 MP: 19939790284 E-mail:
作者简介:

迟栋（1984-），男，副教授，主要从事抗肿瘤成分分离筛选相关工作

Literature analysis of clinical characteristics of hypersensitivity reactions induced by etoposide
Dong CHI1, Chun-xing WU2, Han-meng DING3, Qing-jie SHI4, Peng-hui LIU5
Affiliations
  • 1.Nanyang Medical College, Nanyang 473000, Henan Province, China
  • 2.Binzhou Central Hospital, Binzhou 251700, Shandong Province, China
  • 3.95977 Troups of the Chinese People’s Liberation Army, Beijing 100076, China
  • 4.Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450003, Henan Province, China
  • 5.Fangchenggang Vocational and Technical College, Fangchenggang 538000, Guangxi Zhuang Autonomous Region, China
出版时间: 2025-10-28 doi: 10.13699/j.cnki.1001-6821.2025.20.015
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摘要
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目的

收集依托泊苷致过敏反应的个案报道并系统总结过敏反应发生的特点、临床表现及治疗转归等，以期为依托泊苷的安全使用提供参考。

方法

以中国知网中国医院知识库、万方医学网、维普网、Pubmed以及Web of Science等数据库为来源，检索收集依托泊苷致过敏反应的病例报道，并统计分析患者性别、年龄、用药情况、过敏反应发生时间以及处置转归等基本信息。

结果

共纳入27篇个案报道，涉及34例患者，其中男性21例，女性12例，还有一名患者性别未提及。患者平均年龄（45.83±15.50）岁，40岁以上占比约为60%。纳入的病例以肺癌患者居多，依托泊苷致过敏反应的发生时间较为短暂，有18例患者在用药的1~10 min内即出现了过敏反应，仅3例患者过敏反应的发生时间在1 h以上。过敏反应可累及呼吸、循环和皮肤及其附件等系统，并以呼吸困难、胸闷、丘疹、心慌、低血压、发绀等为常见临床表现，且不乏过敏性休克等严重病例。所有病例经干预后均好转，而经激素或抗过敏药等处理后，患者再次输注依托泊苷则未再出现过敏反应。

结论

依托泊苷所致过敏反应属速发型超敏反应，具有发生时间短暂、进展迅速、预后良好等特点；临床实际中应密切观察患者在输注依托泊苷时的状态，加强用药监护，确保依托泊苷使用的安全性。

依托泊苷  /  过敏反应  /  临床特点  /  文献分析  /  治疗转归
Objective

To collect the case reports of hypersensitivity reactions induced by etoposide and systematically summarize the characteristics, clinical manifestations, and treatment outcomes of hypersensitivity reactions, in order to provide corresponding reference for the safe use of etoposide.

Methods

The related case reports of hypersensitivity reactions induced by etoposide were retrieved and collected from databases such as China National Knowledge Infrastructure China Hospital Knowledge Base, Wanfang, VIP, Pubmed and Web of Science, and basic information such as patient gender, age, medication use, time of hypersensitivity reaction occurrence, and treatment outcomes was statistically analyzed as well.

Results

A total of 27 case reports were finally included, involving 34 patients which included 21 males and 12 females and 1 patient whose gender was not mentioned. The average age of the patients was (45.83±15.50) years, with approximately 60% being over 40 years old. The majority of included cases were lung cancer patients, and the occurrence time of hypersensitivity reactions induced by etoposide was relatively short, with 18 patients experiencing hypersensitivity reactions within 1-10 minutes of medication, while only 3 patients had hypersensitivity reactions that occurred for more than 1 hour. Hypersensitivity reactions could affect many systems of the body, such as respiratory, circulatory, skin and its appendages. Common clinical manifestations of hypersensitivity reactions included difficulty breathing, chest tightness, papules, palpitations, hypotension, cyanosis; in addition, there were many serious cases such as anaphylactic shock. All cases showed improvement after treatment, and the patient did not experience any hypersensitivity reactions after receiving another infusion of etoposide, which had been pre treated with hormones or anti allergic drugs.

Conclusion

Hypersensitivity reactions induced by etoposide belong to immediate hypersensitivity reactions, characterized by short onset time, rapid progression, and good prognosis. In clinical practice, it is necessary to closely observe the status of patients during infusion of etoposide, strengthen medication monitoring, which can ensure the safety use of etoposide.

etoposide  /  hypersensitivity reaction  /  clinical characteristics  /  literature analysis  /  treatment outcome
迟栋, 吴春兴, 丁韩梦, 师卿杰, 刘鹏辉. 依托泊苷致过敏反应临床特点的文献分析. 中国临床药理学杂志, 2025 , 41 (20) : 2934 -2940 . DOI: 10.13699/j.cnki.1001-6821.2025.20.015
Dong CHI, Chun-xing WU, Han-meng DING, Qing-jie SHI, Peng-hui LIU. Literature analysis of clinical characteristics of hypersensitivity reactions induced by etoposide[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (20) : 2934 -2940 . DOI: 10.13699/j.cnki.1001-6821.2025.20.015
基金
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  • 河南省中医药科学研究专项基金资助项目(2023ZY2106)
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doi: 10.13699/j.cnki.1001-6821.2025.20.015
  • 接收时间：2025-07-15
  • 首发时间：2026-08-05
  • 出版时间：2025-10-28
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  • 收稿日期：2025-07-15
基金
河南省中医药科学研究专项基金资助项目(2023ZY2106)
作者信息
    1.南阳医学高等专科学校 河南 南阳 473000
    2.滨州市中心医院，山东 滨州 251700
    3.邓州市中国人民解放军95977部队，北京 100076
    4.河南中医药大学 第三附属医院，河南 郑州 450003
    5.防城港职业技术学院，广西 防城港 538000

通讯作者:

刘鹏辉，副教授 MP: 19939790284 E-mail:
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https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.20.015
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2种不同金属材料的力学参数
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Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
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species		 占总种数比例
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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