Article(id=1291704913873101329, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.20.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1744819200000, receivedDateStr=2025-04-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896050183, onlineDateStr=2026-08-05, pubDate=1761580800000, pubDateStr=2025-10-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896050183, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896050183, creator=13701087609, updateTime=1785896050183, updator=13701087609, issue=Issue{id=1291704786705993936, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='20', pageStart='2851', pageEnd='3000', issueExtLink='null', onlineDate='null', pubDate='1761580800000', pubDateStr='2025-10-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896019864, creator='13701087609', updateTime=1785896741492, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707813508702571, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707813508702572, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2924, endPage=2928, ext={EN=ArticleExt(id=1291704914066039314, articleId=1291704913873101329, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Determination and pharmacokinetic study of arecoline in rat plasma by HPLC, columnId=1246531413395263850, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Research Method, runingTitle=null, highlight=null, articleAbstract=
Objective To establish a high performance liquid chromatography method for the determination of arecoline in rat plasma, to study the pharmacokinetic behavior of arecoline in rats, and to provide a scientific basis for the pharmacodynamic substance basis of arecoline.
Methods SD rats were given low, medium and high (10, 20 and 30 mg·kg-1) aqueous solutions of arecine by gavage, and blood was collected from the fundus venous plexus at different time points, and the supernatant was extracted by ethyl acetate and then injected for analysis. Puerarin was used as the internal standard to detect the content of arecine in plasma by HPLC, the mobile phase was acetonitrile-methanol-0.1% triethylamine aqueous solution (6∶16∶78, pH=4.5), isocratic elution, flow rate 1.0 mL·min-1, detection wavelength 215 nm, column temperature 30 ℃, and the pharmacokinetic parameters were calculated by DAS2.0 software.
Results The linear relationship between arecaine in 0.5-32.0 μg·mL-1 was good, the standard curve was y=0.0512x-0.0326(r=0.9960), the lower limit of quantification was 0.5 μg·mL-1, and the precision, repeatability, stability and recovery test results were good. The main pharmacokinetic parameters of arecaine in the low-, medium-, and high-dose groups were (1.36±0.21), (2.15±0.72) and (2.75±0.69) mg·L-1, and the area under the curve (AUC0-t) was (3.04±0.24), (3.87±1.02) and (4.49±0.76) mg·L-1·h, and the elimination half-lives (t1/2) were (3.67±1.73), (2.88±1.66) and (3.12±1.86) h.
Conclusion The method is simple and rapid, suitable for the pharmacokinetic study of arecoline in rat plasma.
, authors=Chun-xue ZHAO, Yu-zhu LI, Feng LIU, Lian ZHONG, Lan-jun CHEN, Wei LI, Yue-sheng XIE, authorsList=Chun-xue ZHAO, Yu-zhu LI, Feng LIU, Lian ZHONG, Lan-jun CHEN, Wei LI, Yue-sheng XIE, authorCompany=null, correspAuthors=Yue-sheng XIE, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704914523218451, articleId=1291704913873101329, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=用HPLC法测定槟榔碱在大鼠血浆中浓度及药代动力学研究, columnId=1246531413600784769, journalTitle=中国临床药理学杂志, columnName=研究方法, runingTitle=null, highlight=null, articleAbstract=
目的 采用高效液相色谱法建立槟榔碱在大鼠血浆中含量测定方法，研究槟榔碱在大鼠体内药代动力学行为，为槟榔碱的药效物质基础提供科学依据。
方法 SD大鼠灌胃给予低、中、高（10、20、30 mg·kg-1）三个剂量槟榔碱水溶液，于不同时间点眼底静脉丛采血，采用乙酸乙酯萃取后取上清进样分析。以葛根素为内标物采用HPLC法检测血浆中槟榔碱含量，流动相为乙腈-甲醇-0.1%三乙胺水溶液（6∶16∶78，pH=4.5），等度洗脱，流速1.0 mL·min-1，检测波长215 nm，柱温30 ℃，运用DAS 2.0软件计算药代动力学参数。
结果 槟榔碱在0.5~32.0 μg·mL-1内线性关系良好，其标准曲线为y=5.12×10-2x-3.26×10-2（r=0.996 0），定量下限0.5 μg·mL-1，精密度、重复性、稳定性及回收率试验结果良好。槟榔碱低、中、高剂量组主要药代动力学参数：药峰浓度（Cmax）分别为（1.36±0.21）、（2.15±0.72）和（2.75±0.69）mg·L-1，药时曲线下面积（AUC0-t）分别为（3.04±0.24）、（3.87±1.02）和（4.49±0.76）mg·L-1·h，消除半衰期（t1/2）分别为（3.67±1.73）、（2.88±1.66）和（3.12±1.86）h。
结论 该方法简便快捷，适用于槟榔碱大鼠血浆中的药代动力学研究。
, authors=赵春雪, 李雨洙, 刘峰, 钟莲, 陈兰君, 李伟, 谢跃生, authorsList=赵春雪, 李雨洙, 刘峰, 钟莲, 陈兰君, 李伟, 谢跃生, authorCompany=null, correspAuthors=谢跃生, authorNote=
赵春雪（2001-），女，硕士研究生，主要从事药代动力学研究
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