Article(id=1291704790468284627, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.20.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1753891200000, receivedDateStr=2025-07-31, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896020762, onlineDateStr=2026-08-05, pubDate=1761580800000, pubDateStr=2025-10-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896020762, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896020762, creator=13701087609, updateTime=1785896020762, updator=13701087609, issue=Issue{id=1291704786705993936, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='20', pageStart='2851', pageEnd='3000', issueExtLink='null', onlineDate='null', pubDate='1761580800000', pubDateStr='2025-10-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896019864, creator='13701087609', updateTime=1785896741492, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707813508702571, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707813508702572, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2912, endPage=2917, ext={EN=ArticleExt(id=1291704791290368213, articleId=1291704790468284627, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research on protective effects of bifendate on metabolic dysfunction-associated steatotic liver disease in mice, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the protective effects and potential mechanism of bifendate against methionine-choline-deficient (MCD) diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD) in mice.
Methods A total of 24 male C57BL/6J mice were randomly divided into control group, model group, and experimental group. The model group was fed with MCD diet to establish the MASLD model, while the experimental group received bifendate (300 mg·kg-1) in addition to the MCD diet. After 6 weeks, liver pathology was assessed using Hematoxylin-Eosin (H&E) and Oil Red O staining. Hepatic triglyceride (TG) content, serum lipopolysaccharide (LPS) and serum alanine aminotransferase (ALT) levels were measured using assay kits. Gut microbiota composition and diversity were analyzed by high-throughput sequencing. The relative expression levels of the intestinal tight junction protein ZO-1 and Occludin were detected by Western blot.
Results Oil Red O staining revealed that the number and degree of hepatocellular steatosis were significantly reduced in the experimental group compared to the model group. The MCD diet successfully induced steatohepatitis in mice, characterized by significantly increased hepatic TG, serum ALT, and marked hepatocellular steatosis. Hepatic TG contents were (66.43±14.58), (231.29±20.26), and (190.39±29.33) μmol·g-1 for the control, model and experimental groups, respectively; serum ALT levels were (52.04±16.80), (219.74±123.37) and (31.68±10.70) IU·L-1, respectively; serum LPS levels were (0.89±0.57), (4.01±0.65) and (0.52±0.25) EU·mL-1, respectively. The relative expression levels of ZO-1 were 1.00±0.94, 0.06±0.03 and 0.25±0.27, respectively, and for Occludin were 1.00±0.57, 0.06±0.03 and 0.15±0.15, respectively. Compared with the model group, the experimental group showed statistically significant differences in all the aforementioned indicators (P<0.05, P<0.001). Bifendate intervention significantly reduced serum ALT and hepatic TG levels and markedly alleviated the extent and severity of hepatocellular steatosis. Regarding the gut-liver axis, bifendate significantly improved the diversity and richness of the gut microbiota in model mice, particularly increasing the relative abundance of Bilophila and Desulfovibrio, genera closely related to bile acid metabolism. Furthermore, bifendate intervention significantly up-regulated the expression of intestinal tight junction proteins and decreased serum LPS levels.
Conclusion Bifendate can effectively ameliorate MCD diet-induced steatohepatitis in mice. Its protective mechanism is closely related to the regulation of the gut-liver axis, including remodeling the intestinal flora structure (increasing the relative abundance of Bilophila and Desulfovibrio), enhancing intestinal barrier function (upregulating tight junction proteins, reducing serum LPS), and potentially affecting bile acid metabolism.
, authors=Hong LI
1, Jie-yi CHEN
2, Qing-hua SUN
1, Rong-yue LIANG
1, Zhi-fang FU
1, Hong-mei JIAO
1, authorsList=Hong LI, Jie-yi CHEN, Qing-hua SUN, Rong-yue LIANG, Zhi-fang FU, Hong-mei JIAO, authorCompany=null, correspAuthors=Zhi-fang FU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704793337188566, articleId=1291704790468284627, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=联苯双酯对小鼠代谢功能障碍相关脂肪性肝病的保护作用研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨联苯双酯对蛋氨酸-胆碱缺乏（MCD）饮食诱导的小鼠代谢功能障碍相关脂肪性肝病（MASLD）的保护作用及其潜在机制。
方法 雄性C57BL/6J小鼠24只，随机分为对照组、模型组以及试验组，模型组用MCD饮食喂养建立MASLD模型，试验组在建模的基础上给予联苯双酯（300 mg·kg-1）干预。6周后，用苏木精-伊红法和油红O染色法评估小鼠肝病理学，用试剂盒法检测肝甘油三酯（TG）含量、血清脂多糖（LPS）水平和血清丙氨酸氨基转移酶（ALT）水平，用高通量测序分析法检测肠道菌群组成与多样性，用蛋白质印迹法检测闭锁小带蛋白-1（ZO-1）和闭合蛋白（Occludin）的相对表达水平。
结果 油红O染色显示，试验组较模型组的肝细胞脂肪变性数量和程度均显著降低。MCD饮食成功诱导小鼠脂肪性肝炎，表现为肝TG和血清ALT均显著升高及明显肝细胞脂肪变性。对照组、模型组和试验组的肝TG含量分别为（66.43±14.58）、（231.29±20.26）和（190.39±29.33）μmol·g-1；血清ALT水平分别为（52.04±16.80）、（219.74±123.37）和（31.68±10.70）IU·L-1；LPS水平分别为（0.89±0.57）、（4.01±0.65）和（0.52±0.25）EU·mL-1；ZO-1蛋白相对表达水平分别为1.00±0.94、0.06±0.03和0.25±0.27；Occludin蛋白相对表达水平分别为1.00±0.57、0.06±0.03和0.15±0.15，试验组的上述指标与模型组比较，在统计学上差异均有统计学意义（P<0.05，P<0.001）。联苯双酯干预可显著降低血清ALT和肝TG水平，并显著减轻肝细胞脂肪变性的数量和严重程度。在肠-肝轴方面，联苯双酯显著改善了模型小鼠肠道菌群的多样性和丰度，特别是增加了与胆汁酸代谢密切相关的嗜胆菌属（Bilophila）和脱硫弧菌属（Desulfovibrio）的相对丰度。同时，联苯双酯干预显著上调了肠道紧密连接蛋白ZO-1和Occludin的表达，并降低了血清LPS水平。
结论 联苯双酯有效改善MCD饮食诱导的小鼠MASLD，其作用机制与调节肠-肝轴密切相关，包括重塑肠道菌群结构（增加Bilophila和Desulfovibrio相对丰度）、增强肠道屏障功能（上调紧密连接蛋白、降低血清LPS）以及潜在影响胆汁酸代谢。
, authors=李虹
1, 陈洁仪
2, 孙清华
1, 梁荣月
1, 付志方
1, 焦红梅
1, authorsList=李虹, 陈洁仪, 孙清华, 梁荣月, 付志方, 焦红梅, authorCompany=null, correspAuthors=付志方, authorNote=
李虹（1975-），女，副主任医师，主要从事老年医学方面的临床工作和研究
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=LDXaY8eF80quKmWpjwrtfg==, magXml=Bztr4C5VogveJGB/WIzABg==, pdfUrl=null, pdf=9fmD6rZR80qGly3cVkP7ZA==, pdfFileSize=1868291, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=Wpb8lPhWbfhaplAPBKqZ4w==, mapNumber=null, fund=null)}, authors=[Author(id=1292440007298535454, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292440007390810144, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, authorId=1292440007298535454, language=EN, stringName=Hong LI, firstName=Hong, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.Department of Geriatrics, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292440007462113313, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, authorId=1292440007298535454, language=CN, stringName=李虹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.北京大学 第一医院 老年病内科，北京 100034, bio={"content":"
李虹（1975-），女，副主任医师，主要从事老年医学方面的临床工作和研究
"}, bioImg=null, bioContent=
李虹（1975-），女，副主任医师，主要从事老年医学方面的临床工作和研究
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292440007101403159, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, xref=1., ext=[AuthorCompanyExt(id=1292440007118180376, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007101403159, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Department of Geriatrics, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1292440007130763289, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007101403159, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.北京大学 第一医院 老年病内科，北京 100034)])]), Author(id=1292440007525027875, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292440007600525349, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, authorId=1292440007525027875, language=EN, stringName=Jie-yi CHEN, firstName=Jie-yi, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2.Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292440007667634214, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, authorId=1292440007525027875, language=CN, stringName=陈洁仪, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2.中国医学科学院 药物研究所，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292440007214649370, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, xref=2., ext=[AuthorCompanyExt(id=1292440007223037979, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007214649370, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China), AuthorCompanyExt(id=1292440007231426588, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007214649370, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.中国医学科学院 药物研究所，北京 100050)])]), Author(id=1292440007726354472, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292440007801851946, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, authorId=1292440007726354472, language=EN, stringName=Qing-hua SUN, firstName=Qing-hua, middleName=null, lastName=SUN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.Department of Geriatrics, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292440007873155115, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, authorId=1292440007726354472, language=CN, stringName=孙清华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.北京大学 第一医院 老年病内科，北京 100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292440007101403159, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, xref=1., ext=[AuthorCompanyExt(id=1292440007118180376, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007101403159, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Department of Geriatrics, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1292440007130763289, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007101403159, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.北京大学 第一医院 老年病内科，北京 100034)])]), Author(id=1292440007961235501, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292440009672511535, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, authorId=1292440007961235501, language=EN, stringName=Rong-yue LIANG, firstName=Rong-yue, middleName=null, lastName=LIANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.Department of Geriatrics, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292440011622862896, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, authorId=1292440007961235501, language=CN, stringName=梁荣月, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.北京大学 第一医院 老年病内科，北京 100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292440007101403159, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, xref=1., ext=[AuthorCompanyExt(id=1292440007118180376, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007101403159, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Department of Geriatrics, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1292440007130763289, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007101403159, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.北京大学 第一医院 老年病内科，北京 100034)])]), Author(id=1292440011723526194, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=fuzhifang@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1292440011799023668, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, authorId=1292440011723526194, language=EN, stringName=Zhi-fang FU, firstName=Zhi-fang, middleName=null, lastName=FU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.Department of Geriatrics, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292440011887104053, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, authorId=1292440011723526194, language=CN, stringName=付志方, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.北京大学 第一医院 老年病内科，北京 100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292440007101403159, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, xref=1., ext=[AuthorCompanyExt(id=1292440007118180376, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007101403159, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Department of Geriatrics, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1292440007130763289, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007101403159, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.北京大学 第一医院 老年病内科，北京 100034)])]), Author(id=1292440011945824311, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292440012029710393, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, authorId=1292440011945824311, language=EN, stringName=Hong-mei JIAO, firstName=Hong-mei, middleName=null, lastName=JIAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.Department of Geriatrics, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292440012109402170, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, authorId=1292440011945824311, language=CN, stringName=焦红梅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.北京大学 第一医院 老年病内科，北京 100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292440007101403159, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, xref=1., ext=[AuthorCompanyExt(id=1292440007118180376, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007101403159, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Department of Geriatrics, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1292440007130763289, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007101403159, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.北京大学 第一医院 老年病内科，北京 100034)])])], keywords=[Keyword(id=1292440012247814203, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, language=EN, orderNo=1, keyword=bifendate), Keyword(id=1292440012331700284, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, language=EN, orderNo=2, keyword=metabolic dysfunction-associated steatotic liver disease), Keyword(id=1292440012403003453, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, language=EN, orderNo=3, keyword=gut-liver axis), Keyword(id=1292440012465918014, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, language=EN, orderNo=4, keyword=protective effect), Keyword(id=1292440014152028223, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, language=CN, orderNo=1, keyword=联苯双酯), Keyword(id=1292440014244302912, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, language=CN, orderNo=2, keyword=代谢功能障碍相关脂肪性肝病), Keyword(id=1292440014428852289, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, language=CN, orderNo=3, keyword=肠-肝轴), Keyword(id=1292440014487572546, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, language=CN, orderNo=4, keyword=保护作用)], refs=null, funds=[Fund(id=1292440014625984579, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, awardId=null, language=CN, fundingSource=北京大学第一医院青年临床研究专项基金资助项目, fundOrder=null, country=null), Fund(id=1292440014718259268, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, awardId=null, language=CN, fundingSource=北京大学第一医院中西医协同旗舰医院建设试点基金资助项目, fundOrder=null, country=null)], companyList=[AuthorCompany(id=1292440007101403159, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, xref=1., ext=[AuthorCompanyExt(id=1292440007118180376, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007101403159, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Department of Geriatrics, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1292440007130763289, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007101403159, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.北京大学 第一医院 老年病内科，北京 100034)]), AuthorCompany(id=1292440007214649370, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, xref=2., ext=[AuthorCompanyExt(id=1292440007223037979, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007214649370, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China), AuthorCompanyExt(id=1292440007231426588, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704790468284627, companyId=1292440007214649370, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.中国医学科学院 药物研究所，北京 100050)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1788948995538, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509895005466898, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995591, updatedTime=1788948995591, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1304509895047409939, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995601, updatedTime=1788948995601, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.20.011, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.20.011, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.20.011, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.20.011, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1761580800000, fullTextJson=null, articleText=null, reference=null)
PDF下载
全屏
124
26
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
