Article(id=1292439993415393905, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.20.004, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1754841600000, receivedDateStr=2025-08-11, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1786071306804, onlineDateStr=2026-08-07, pubDate=1761580800000, pubDateStr=2025-10-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1786071306804, onlineIssueDateStr=2026-08-07, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1786071306804, creator=13701087609, updateTime=1786071306804, updator=13701087609, issue=Issue{id=1291704786705993936, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='20', pageStart='2851', pageEnd='3000', issueExtLink='null', onlineDate='null', pubDate='1761580800000', pubDateStr='2025-10-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896019864, creator='13701087609', updateTime=1785896741492, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707813508702571, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707813508702572, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2869, endPage=2874, ext={EN=ArticleExt(id=1292439993641886322, articleId=1292439993415393905, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trail of butylphthalide combined with dual antibiotics in the treatment of non-disabling ischemic cerebrovascular events, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the the clincial efficacy and safety of butylphthalide soft capsules combined with dual anti-platelet therapy (DAPT) in the treatment of non-disabling ischemic cerebrovascular events (NICE).
Methods The patients with NICE admitted to the hospital were enrolled as the research objects. According to random number table method, they were divided into treatment group and control group. Control group was treated with DAPT (aspirin enteric-coated tablets 100 mg·d-1+ clopidogrel bisulfate tablets 75 mg·d-1), while treatment group was treated with butylphthalide soft capsules 0.6 g·d-1 on basis of control group for 1 month. The clinical curative effect, incidence of recurrent cerebral infarction within 6 months of follow-up, levels of NLR family Pyrin domain containing protein 3 (NLRP3) inflammasome, homocysteine (Hcy) and interleukin (IL)-6, plasma viscosity, whole blood high-shear viscosity, low-shear viscosity and hematocrit were compared between the two groups, and the safety was evaluated.
Results Among the 130 patients in this study, there were 120 cases included finally after excluding 10 cases not meeting the inclusion criteria. According to random number table method, they were divided into treatment group and control group, and there was no case lost to follow-up in the study process. After treatment, total response rate in treatment group was 93.33% (56 cases /60 cases) which was statistically significantly higher than that in control group [80.00% (48 cases /60 cases), P<0.05]. After treatment, scores of National Institutes of Health stroke scale (NIHSS) in treatment group and control group were (1.10±0.12) and (1.85±0.21) points, scores of modified Rankin scale (mRS) were (1.10±0.12) and (1.82±0.19) points, scores of activity of daily living (ADL) were (68.97±6.96) and (60.11±6.12) points, levels of NLRP3 inflammasome were (1.40±0.16) and (1.96±0.21) μg·L-1, IL-6 levels were (24.15±2.57) and (31.27±3.35) pg·mL-1, Hcy levels were (20.18±2.13) and (27.78±3.14) μmol·L-1, plasma viscosity were (1.59±0.16) and (1.81±0.19) mPa·s-1, whole blood high-shear viscosity were (4.01±0.41) and (4.78±0.50) mPa·s-1, whole blood low-shear viscosity were (10.42±1.15) and (11.87±1.20) mPa·s-1, and hematocrit were (0.25±0.03) and (0.33±0.04) L·L-1, there were statistically significant differences in the above indexes between the two groups (all P<0.05). After 6 months of follow-up, incidence of recurrent cerebral infarction in treatment group was 8.33% (5 cases /60 cases) which was statistically significantly lower than that in control group [23.33% (14 cases / 60 cases), P<0.05]. The main adverse drug reactions in treatment group were subcutaneous ecchymosis 1 case (1.67%), nausea 1 case (1.67%) and gastrointestinal discomfort 3 cases (5.00%), while which in control group were subcutaneous ecchymosis 2 cases (3.33%), nausea 2 cases (3.33%), vomiting 1 case (1.67%) and gastrointestinal discomfort 2 cases (3.33%). There was no significant difference in total incidence of adverse drug reactions between treatment group and control group (8.33% vs 11.67%, P>0.05).
Conclusion Curative effect of butylphthalide soft capsule combined with DAPT is good in NICE patients, which can reduce level of NLRP3 inflammasome, improve blood circulation, reduce incidence of recurrent cerebral infarction and will not increase adverse drug reactions.
, authors=Xiao-li WANG, Wei-jian MENG, Xin-ying WANG, Wen-ting DING, Zhi WANG, authorsList=Xiao-li WANG, Wei-jian MENG, Xin-ying WANG, Wen-ting DING, Zhi WANG, authorCompany=null, correspAuthors=Xiao-li WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292439993931293299, articleId=1292439993415393905, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=丁苯酞联合双抗治疗非致残性缺血性脑血管事件的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察丁苯酞软胶囊联合双联抗血小板（双抗）治疗非致残性缺血性脑血管事件（NICE）的临床疗效和安全性。
方法 以本院收治的NICE患者纳入为研究对象。按照随机数表法分为试验组和对照组。对照组用双抗（阿司匹林肠溶片100 mg·d-1+硫酸氢氯吡格雷片75 mg·d-1）治疗，试验组在对照组基础上加用丁苯酞软胶囊0.6 g·d-1，均连续治疗1个月。比较2组患者的临床疗效、随访6个月内再发脑梗死发生率、NLR家族Pyrin域蛋白3（NLRP3）炎症小体水平、高半胱氨酸（Hcy）水平、白介素（IL）-6水平、血浆粘度、全血高切粘度、全血低切粘度和红细胞比容，并进行安全性评价。
结果 本研究共筛选130例，排除不符合纳入标准的10例后，最终纳入120例，按随机数表法分为试验组和对照组，研究过程中无患者脱落。治疗后，试验组和对照组患者的总有效率分别为93.33%（56例/60例）和80.00%（48例/60例），试验组显著高于对照组（P<0.05）。治疗后，试验组和对照组的美国国立卫生研究院卒中量表（NIHSS）评分分别为（1.10±0.12）和（1.85±0.21）分；改良Rankin评分量表（mRS）评分分别为（1.10±0.12）和（1.82±0.19）分；日常生活活动能力量表（ADL）评分分别为（68.97±6.96）和（60.11±6.12）分；NLRP3炎症小体水平分别为（1.40±0.16）和（1.96±0.21）μg·L-1；IL-6水平分别为（24.15±2.57）和（31.27±3.35）pg·mL-1；Hcy水平分别为（20.18±2.13）和（27.78±3.14）μmol·L-1；血浆粘度水平分别为（1.59±0.16）和（1.81±0.19）mPa·s-1；全血高切粘度水平分别为（4.01±0.41）和（4.78±0.50）mPa·s-1；全血低切粘度水平分别为（10.42±1.15）和（11.87±1.20）mPa·s-1；红细胞比容分别为（0.25±0.03）和（0.33±0.04）L·L-1，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（均P<0.05）。随访6个月后，试验组再发脑梗死发生率为8.33%（5例/60例），显著低于对照组的23.33%（14例/60例）（P<0.05）；试验组主要的药物不良反应为皮下瘀斑1例（1.67%）、恶心1例（1.67%）和胃肠道不适3例（5.00%），对照组为皮下瘀斑2例（3.33%）、恶心2例（3.33%）、呕吐1例（1.67%）、胃肠道不适2例（3.33%）。试验组和对照组的药物不良反应总发生率分别为8.33%和11.67%，在统计学上差异无统计学意义（P>0.05）。
结论 丁苯酞软胶囊联合双抗治疗NICE患者获得较好疗效，降低NLRP3炎症小体水平，改善血液循环，降低再发脑梗死发生概率，且不会增加药物不良反应。
, authors=王晓莉, 孟伟建, 王心颖, 丁文婷, 王智, authorsList=王晓莉, 孟伟建, 王心颖, 丁文婷, 王智, authorCompany=null, correspAuthors=王晓莉, authorNote=
王晓莉（1978-）女，副主任医师，主要从事脑血管病、感染、认知等方面的临床工作和研究
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