Article(id=1292439988818436680, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.20.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1747152000000, receivedDateStr=2025-05-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1786071305708, onlineDateStr=2026-08-07, pubDate=1761580800000, pubDateStr=2025-10-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1786071305708, onlineIssueDateStr=2026-08-07, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1786071305708, creator=13701087609, updateTime=1786071305708, updator=13701087609, issue=Issue{id=1291704786705993936, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='20', pageStart='2851', pageEnd='3000', issueExtLink='null', onlineDate='null', pubDate='1761580800000', pubDateStr='2025-10-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896019864, creator='13701087609', updateTime=1785896741492, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707813508702571, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707813508702572, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2851, endPage=2855, ext={EN=ArticleExt(id=1292439989019763273, articleId=1292439988818436680, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trail of intravenous drip and aerosol inhalation of polymyxin E in patients with severe neurological disease and
Acinetobacter baumannii infection, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe clinical curative effect and safety of intravenous drip and aerosol inhalation of colistimethate sodium for injection in patients with severe neurological disease and Acinetobacter baumannii (AB) pulmonary infection.
Methods According to queuing method, patients with severe neurological disease and AB pulmonary infection in the hospital were divided into treatment group and control group. Control group was treated with colistimethate sodium for injection (150 mg bid, intravenous drip), while treatment group was treated with colistimethate sodium for injection (75 mg bid, aerosol inhalation) on basis of control group. All patients were treated for 5 days. The clinical curative effect, renal function, inflammatory response, bacterial clearance rates and prognosis in the two groups were compared, and the safety was evaluated.
Results Among the 80 patients, there were 40 cases in treatment group and 40 cases in control group. After treatment, total response rates of treatment group and control group were 72.50% (29 cases/40 cases) and 42.50% (17 cases/40 cases), levels of serum interleukin-8 were (4.07±1.01) and (5.01±1.65) pg·mL-1, procalcitonin levels were 0.90(0.60, 1.35) and 1.50(1.05, 2.00) ng·mL-1, C-reactive protein levels were (5.57±3.28) and (10.57±6.09) mg·L-1, bacterial clearance rates were 60.00% (24 cases/40 cases) and 35.00% (14 cases/40 cases), and infection-related 28 d mortality rates were 5.00% (2 cases/40 cases) and 20.00% (8 cases/40 cases), the differences between the two groups were all statistically significant (all P<0.05). After treatment, levels of serum creatinine in treatment group and control group were (86.22±9.84) and (87.27±10.54) μmol·L-1, and levels of blood urea nitrogen were (7.98±2.44) and (7.86±2.47) mmol·L-1, the differences were not statistically significant (both P>0.05). The main adverse drug reactions in treatment group were rash, diarrhea and respiratory depression, while which in control group were rash and diarrhea. The difference in total incidence of adverse drug reactions between treatment group and control group was statistically significant (7.50% vs 5.00%, P>0.05).
Conclusion Curative effect of intravenous drip combined with aerosol inhalation of polymyxin E is significant in patients with severe neurological disease and AB infection, which can effectively increase bacterial clearance rate, reduce inflammatory response and mortality, and will not increase renal injury.
, authors=Han-mo BAO, Yu-xuan WU, Xu WANG, Wen CAI, Yong WANG, authorsList=Han-mo BAO, Yu-xuan WU, Xu WANG, Wen CAI, Yong WANG, authorCompany=null, correspAuthors=Yu-xuan WU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292439989304975946, articleId=1292439988818436680, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=多粘菌素E静脉滴注联合雾化在神经重症伴鲍曼不动杆菌感染患者中的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察注射用多粘菌素E甲磺酸钠静脉滴注联合雾化对神经重症伴鲍曼不动杆菌（Acinetobacter baumannii，AB）肺部感染患者的临床疗效和安全性。
方法 以本院收治的神经重症伴AB肺部感染患者按照队列法分为试验组和对照组。对照组给予注射用多粘菌素E甲磺酸钠（150 mg bid，静脉滴注）治疗。试验组在对照组基础上联合注射用多粘菌素E甲磺酸钠（75 mg bid，雾化吸入）治疗。2组均治疗5 d。比较2组患者的临床疗效、肾功能、炎症反应、细菌清除率和预后，并进行安全性评价。
结果 共纳入80例患者，试验组和对照组均纳入40例。治疗后，试验组和对照组的总有效率分别为72.50%（29例/40例）和42.50%（17例/40例），血清白细胞介素8分别为（4.07±1.01）和（5.01±1.65）pg·mL-1，降钙素原分别为0.90（0.60，1.35）和1.50（1.05，2.00）ng·mL-1，C反应蛋白分别为（5.57±3.28）和（10.57±6.09）mg·L-1，细菌清除率分别为60.00%（24例/40例）和35.00%（14例/40例），感染相关28 d病死率分别为5.00%（2例/40例）和20.00%（8例/40例），试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（均P<0.05）。治疗后，试验组和对照组的血清肌酸酐分别为（86.22±9.84）和（87.27±10.54）μmol·L-1，血尿素氮分别为（7.98±2.44）和（7.86±2.47）mmol·L-1，在统计学上差异均无统计学意义（均P>0.05）。试验组的药物不良反应主要有皮疹、腹泻及呼吸抑制，对照组的药物不良反应主要有皮疹及腹泻。试验组和对照组的总药物不良反应发生率分别为7.50%和5.00%，在统计学上差异无统计学意义（P>0.05）。
结论 多粘菌素E静脉滴注联合雾化给药对神经重症伴AB感染患者的效果显著，可有效提高细菌清除率，降低炎症反应和病死率，且不会增加对肾功能的损伤。
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鲍翰墨（1990-），男，主治医师，主要从事神经重症方面的临床工作和研究
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