Article(id=1291704986581357329, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.19.019, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1723996800000, receivedDateStr=2024-08-19, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896067518, onlineDateStr=2026-08-05, pubDate=1760630400000, pubDateStr=2025-10-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896067518, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896067518, creator=13701087609, updateTime=1785896067518, updator=13701087609, issue=Issue{id=1291704892859638107, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='19', pageStart='2701', pageEnd='2850', issueExtLink='null', onlineDate='null', pubDate='1760630400000', pubDateStr='2025-10-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896045171, creator='13701087609', updateTime=1785896787712, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708007352656266, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708007352656267, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2822, endPage=2826, ext={EN=ArticleExt(id=1291704986824626962, articleId=1291704986581357329, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of traditional Chinese medicine regulating endoplasmic reticulum stress to prevent and treat diabetic kidney disease, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=
Objective

Diabetic kidney disease (DKD) is one of the common microvascular complications of diabetes mellitus. Due to its insidious onset and unclear pathogenesis, DKD is easy to progress to end-stage renal disease. Endoplasmic reticulum is the main site of protein synthesis and processing in the body. When affected by adverse factors of the body, endoplasmic reticulum stress (ERS) will be triggered, resulting in the accumulation of misfolded or unfolded proteins, resulting in imbalance of the internal environment. Studies have shown that ERS is involved in the core pathogenesis of DKD, and the renal tissue lesions caused by DKD can be effectively alleviated by regulating ERS. This article focuses on the experimental studies on the intervention of ERS with traditional Chinese medicine and its compound in the prevention and treatment of DKD, in order to provide new ideas and reference for clinical treatment of DKD.

, authors=Kun ZHANG1, Zhao-xiao LU1, Xiao-ling CAO1, Jia-ni WEN1, authorsList=Kun ZHANG, Zhao-xiao LU, Xiao-ling CAO, Jia-ni WEN, authorCompany=null, correspAuthors=Zhao-xiao LU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704987168559891, articleId=1291704986581357329, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中药调控内质网应激防治糖尿病肾病的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

糖尿病肾病(DKD)是糖尿病常见的微血管并发症之一,因其起病隐匿且发病机制尚未完全明确,极易进展为终末期肾病。内质网是蛋白质合成和加工的主要场所,当受到机体不利因素影响时,则会引发内质网应激(ERS),导致错误折叠或未折叠的蛋白积累,造成内环境失衡。研究显示ERS参与DKD的核心发病机制,通过调节ERS可以有效缓解DKD导致的肾组织病变。本文着重梳理了中药及复方干预ERS防治DKD相关实验研究,以期为临床治疗DKD提供新的思路和参考依据。

, authors=张坤1, 卢朝晓1, 曹晓玲1, 文佳妮1, authorsList=张坤, 卢朝晓, 曹晓玲, 文佳妮, authorCompany=null, correspAuthors=卢朝晓, authorNote=

张坤(1999-),女,硕士,主要从事内分泌及代谢性疾病中医药防治研究

, correspAuthorsNote=
卢朝晓,副主任医师 MP: 15097272759 E-mail:
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=TfDnqhsU4OAJq/1MRDBa2g==, magXml=fiAvsALAiyD1tqYzz78Zlw==, pdfUrl=null, pdf=ZYXZkSfzI8nbO97/feDezA==, pdfFileSize=1364861, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=LgBVh0+QU4potbWTALB6mQ==, mapNumber=null, fund=null)}, authors=[Author(id=1291704987449578264, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704987516687130, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704987449578264, language=EN, stringName=Kun ZHANG, firstName=Kun, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704987587990299, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704987449578264, language=CN, stringName=张坤, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.天水四零七医院 中西结合科,甘肃 天水 741099, bio={"content":"

张坤(1999-),女,硕士,主要从事内分泌及代谢性疾病中医药防治研究

"}, bioImg=null, bioContent=

张坤(1999-),女,硕士,主要从事内分泌及代谢性疾病中医药防治研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704987374080788, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, xref=1., ext=[AuthorCompanyExt(id=1291704987378275093, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China), AuthorCompanyExt(id=1291704987386663702, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.天水四零七医院 中西结合科,甘肃 天水 741099)])]), Author(id=1291704987663487773, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=501303184@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291704987747373855, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704987663487773, language=EN, stringName=Zhao-xiao LU, firstName=Zhao-xiao, middleName=null, lastName=LU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704987818677024, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704987663487773, language=CN, stringName=卢朝晓, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.天水四零七医院 中西结合科,甘肃 天水 741099, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704987374080788, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, xref=1., ext=[AuthorCompanyExt(id=1291704987378275093, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China), AuthorCompanyExt(id=1291704987386663702, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.天水四零七医院 中西结合科,甘肃 天水 741099)])]), Author(id=1291704987894174498, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704987965477668, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704987894174498, language=EN, stringName=Xiao-ling CAO, firstName=Xiao-ling, middleName=null, lastName=CAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704988049363749, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704987894174498, language=CN, stringName=曹晓玲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.天水四零七医院 中西结合科,甘肃 天水 741099, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704987374080788, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, xref=1., ext=[AuthorCompanyExt(id=1291704987378275093, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China), AuthorCompanyExt(id=1291704987386663702, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.天水四零七医院 中西结合科,甘肃 天水 741099)])]), Author(id=1291704988124861223, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704989848720169, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704988124861223, language=EN, stringName=Jia-ni WEN, firstName=Jia-ni, middleName=null, lastName=WEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704989957772074, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704988124861223, language=CN, stringName=文佳妮, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.天水四零七医院 中西结合科,甘肃 天水 741099, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704987374080788, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, xref=1., ext=[AuthorCompanyExt(id=1291704987378275093, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China), AuthorCompanyExt(id=1291704987386663702, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.天水四零七医院 中西结合科,甘肃 天水 741099)])])], keywords=[Keyword(id=1291704990066823979, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, language=EN, orderNo=1, keyword=traditional Chinese medicine), Keyword(id=1291704990150710060, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, language=EN, orderNo=2, keyword=active ingredients), Keyword(id=1291704990217818925, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, language=EN, orderNo=3, keyword=diabetic kidney disease), Keyword(id=1291704990289122094, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, language=EN, orderNo=4, keyword=endoplasmic reticulum stress), Keyword(id=1291704990381396783, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, language=CN, orderNo=1, keyword=中医药), Keyword(id=1291704990465282864, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, language=CN, orderNo=2, keyword=活性成分), Keyword(id=1291704990532391729, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, language=CN, orderNo=3, keyword=糖尿病肾病), Keyword(id=1291704990603694898, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, language=CN, orderNo=4, keyword=内质网应激)], refs=null, funds=[Fund(id=1291704990704358195, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, awardId=2025-SHFZK-1935, language=CN, fundingSource=天水市科技支撑计划—民生项目编号:(2025-SHFZK-1935), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1291704987374080788, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, xref=1., ext=[AuthorCompanyExt(id=1291704987378275093, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China), AuthorCompanyExt(id=1291704987386663702, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.天水四零七医院 中西结合科,甘肃 天水 741099)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1788948995538, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509895005466898, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995591, updatedTime=1788948995591, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1304509895047409939, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995601, updatedTime=1788948995601, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.19.019, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.19.019, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.19.019, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.19.019, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1760630400000, fullTextJson=null, articleText=null, reference=null)
收藏切换
中药调控内质网应激防治糖尿病肾病的研究现状
收藏切换
PDF下载
张坤 1 , 卢朝晓 1 , 曹晓玲 1 , 文佳妮 1
中国临床药理学杂志 | 综述 2025,41(19): 2822-2826
收起
收藏切换
中国临床药理学杂志 |综述 2025 , 41 (19) : 2822 -2826
中药调控内质网应激防治糖尿病肾病的研究现状
全屏
[Author(id=1291704987449578264, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704987516687130, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704987449578264, language=EN, stringName=Kun ZHANG, firstName=Kun, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704987587990299, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704987449578264, language=CN, stringName=张坤, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.天水四零七医院 中西结合科,甘肃 天水 741099, bio={"content":"

张坤(1999-),女,硕士,主要从事内分泌及代谢性疾病中医药防治研究

"}, bioImg=null, bioContent=

张坤(1999-),女,硕士,主要从事内分泌及代谢性疾病中医药防治研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704987374080788, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, xref=1., ext=[AuthorCompanyExt(id=1291704987378275093, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China), AuthorCompanyExt(id=1291704987386663702, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.天水四零七医院 中西结合科,甘肃 天水 741099)])]), Author(id=1291704987663487773, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=501303184@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291704987747373855, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704987663487773, language=EN, stringName=Zhao-xiao LU, firstName=Zhao-xiao, middleName=null, lastName=LU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704987818677024, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704987663487773, language=CN, stringName=卢朝晓, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.天水四零七医院 中西结合科,甘肃 天水 741099, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704987374080788, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, xref=1., ext=[AuthorCompanyExt(id=1291704987378275093, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China), AuthorCompanyExt(id=1291704987386663702, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.天水四零七医院 中西结合科,甘肃 天水 741099)])]), Author(id=1291704987894174498, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704987965477668, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704987894174498, language=EN, stringName=Xiao-ling CAO, firstName=Xiao-ling, middleName=null, lastName=CAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704988049363749, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704987894174498, language=CN, stringName=曹晓玲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.天水四零七医院 中西结合科,甘肃 天水 741099, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704987374080788, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, xref=1., ext=[AuthorCompanyExt(id=1291704987378275093, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China), AuthorCompanyExt(id=1291704987386663702, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.天水四零七医院 中西结合科,甘肃 天水 741099)])]), Author(id=1291704988124861223, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704989848720169, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704988124861223, language=EN, stringName=Jia-ni WEN, firstName=Jia-ni, middleName=null, lastName=WEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704989957772074, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, authorId=1291704988124861223, language=CN, stringName=文佳妮, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.天水四零七医院 中西结合科,甘肃 天水 741099, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704987374080788, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, xref=1., ext=[AuthorCompanyExt(id=1291704987378275093, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China), AuthorCompanyExt(id=1291704987386663702, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704986581357329, companyId=1291704987374080788, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.天水四零七医院 中西结合科,甘肃 天水 741099)])])]
张坤1, 卢朝晓1 , 曹晓玲1, 文佳妮1
作者信息
  • 1.天水四零七医院 中西结合科,甘肃 天水 741099
通讯作者:
卢朝晓,副主任医师 MP: 15097272759 E-mail:
作者简介:

张坤(1999-),女,硕士,主要从事内分泌及代谢性疾病中医药防治研究

Research status of traditional Chinese medicine regulating endoplasmic reticulum stress to prevent and treat diabetic kidney disease
Kun ZHANG1, Zhao-xiao LU1 , Xiao-ling CAO1, Jia-ni WEN1
Affiliations
  • 1.Integrated Traditional Chinese and Western Medicine Department, Tianshui 407 Hospital, Tianshui 741099, Gansu Province, China
出版时间: 2025-10-17 doi: 10.13699/j.cnki.1001-6821.2025.19.019
文章导航
收藏切换

糖尿病肾病(DKD)是糖尿病常见的微血管并发症之一,因其起病隐匿且发病机制尚未完全明确,极易进展为终末期肾病。内质网是蛋白质合成和加工的主要场所,当受到机体不利因素影响时,则会引发内质网应激(ERS),导致错误折叠或未折叠的蛋白积累,造成内环境失衡。研究显示ERS参与DKD的核心发病机制,通过调节ERS可以有效缓解DKD导致的肾组织病变。本文着重梳理了中药及复方干预ERS防治DKD相关实验研究,以期为临床治疗DKD提供新的思路和参考依据。

中医药  /  活性成分  /  糖尿病肾病  /  内质网应激
Objective

Diabetic kidney disease (DKD) is one of the common microvascular complications of diabetes mellitus. Due to its insidious onset and unclear pathogenesis, DKD is easy to progress to end-stage renal disease. Endoplasmic reticulum is the main site of protein synthesis and processing in the body. When affected by adverse factors of the body, endoplasmic reticulum stress (ERS) will be triggered, resulting in the accumulation of misfolded or unfolded proteins, resulting in imbalance of the internal environment. Studies have shown that ERS is involved in the core pathogenesis of DKD, and the renal tissue lesions caused by DKD can be effectively alleviated by regulating ERS. This article focuses on the experimental studies on the intervention of ERS with traditional Chinese medicine and its compound in the prevention and treatment of DKD, in order to provide new ideas and reference for clinical treatment of DKD.

traditional Chinese medicine  /  active ingredients  /  diabetic kidney disease  /  endoplasmic reticulum stress
张坤, 卢朝晓, 曹晓玲, 文佳妮. 中药调控内质网应激防治糖尿病肾病的研究现状. 中国临床药理学杂志, 2025 , 41 (19) : 2822 -2826 . DOI: 10.13699/j.cnki.1001-6821.2025.19.019
Kun ZHANG, Zhao-xiao LU, Xiao-ling CAO, Jia-ni WEN. Research status of traditional Chinese medicine regulating endoplasmic reticulum stress to prevent and treat diabetic kidney disease[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (19) : 2822 -2826 . DOI: 10.13699/j.cnki.1001-6821.2025.19.019
  • 天水市科技支撑计划—民生项目编号:(2025-SHFZK-1935)
参考文献 引证文献
排序方式:
2025年第41卷第19期
PDF下载
145
23
引用本文
BibTeX
文章信息
doi: 10.13699/j.cnki.1001-6821.2025.19.019
  • 接收时间:2024-08-19
  • 首发时间:2026-08-05
  • 出版时间:2025-10-17
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期:2024-08-19
基金
天水市科技支撑计划—民生项目编号:(2025-SHFZK-1935)
作者信息
    1.天水四零七医院 中西结合科,甘肃 天水 741099

通讯作者:

卢朝晓,副主任医师 MP: 15097272759 E-mail:
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.19.019
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏