Article(id=1291704986581357329, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.19.019, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1723996800000, receivedDateStr=2024-08-19, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896067518, onlineDateStr=2026-08-05, pubDate=1760630400000, pubDateStr=2025-10-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896067518, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896067518, creator=13701087609, updateTime=1785896067518, updator=13701087609, issue=Issue{id=1291704892859638107, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='19', pageStart='2701', pageEnd='2850', issueExtLink='null', onlineDate='null', pubDate='1760630400000', pubDateStr='2025-10-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896045171, creator='13701087609', updateTime=1785896787712, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708007352656266, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708007352656267, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2822, endPage=2826, ext={EN=ArticleExt(id=1291704986824626962, articleId=1291704986581357329, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of traditional Chinese medicine regulating endoplasmic reticulum stress to prevent and treat diabetic kidney disease, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=
Objective Diabetic kidney disease (DKD) is one of the common microvascular complications of diabetes mellitus. Due to its insidious onset and unclear pathogenesis, DKD is easy to progress to end-stage renal disease. Endoplasmic reticulum is the main site of protein synthesis and processing in the body. When affected by adverse factors of the body, endoplasmic reticulum stress (ERS) will be triggered, resulting in the accumulation of misfolded or unfolded proteins, resulting in imbalance of the internal environment. Studies have shown that ERS is involved in the core pathogenesis of DKD, and the renal tissue lesions caused by DKD can be effectively alleviated by regulating ERS. This article focuses on the experimental studies on the intervention of ERS with traditional Chinese medicine and its compound in the prevention and treatment of DKD, in order to provide new ideas and reference for clinical treatment of DKD.
, authors=Kun ZHANG
1, Zhao-xiao LU
1, Xiao-ling CAO
1, Jia-ni WEN
1, authorsList=Kun ZHANG, Zhao-xiao LU, Xiao-ling CAO, Jia-ni WEN, authorCompany=null, correspAuthors=Zhao-xiao LU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704987168559891, articleId=1291704986581357329, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中药调控内质网应激防治糖尿病肾病的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=
糖尿病肾病(DKD)是糖尿病常见的微血管并发症之一,因其起病隐匿且发病机制尚未完全明确,极易进展为终末期肾病。内质网是蛋白质合成和加工的主要场所,当受到机体不利因素影响时,则会引发内质网应激(ERS),导致错误折叠或未折叠的蛋白积累,造成内环境失衡。研究显示ERS参与DKD的核心发病机制,通过调节ERS可以有效缓解DKD导致的肾组织病变。本文着重梳理了中药及复方干预ERS防治DKD相关实验研究,以期为临床治疗DKD提供新的思路和参考依据。
, authors=张坤
1, 卢朝晓
1, 曹晓玲
1, 文佳妮
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张坤(1999-),女,硕士,主要从事内分泌及代谢性疾病中医药防治研究
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