Article(id=1291704970026442757, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.19.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1747670400000, receivedDateStr=2025-05-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896063571, onlineDateStr=2026-08-05, pubDate=1760630400000, pubDateStr=2025-10-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896063571, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896063571, creator=13701087609, updateTime=1785896063571, updator=13701087609, issue=Issue{id=1291704892859638107, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='19', pageStart='2701', pageEnd='2850', issueExtLink='null', onlineDate='null', pubDate='1760630400000', pubDateStr='2025-10-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896045171, creator='13701087609', updateTime=1785896787712, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708007352656266, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708007352656267, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2706, endPage=2710, ext={EN=ArticleExt(id=1291704970424901638, articleId=1291704970026442757, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of combined application of tiotropium bromide and budesonide formoterol in elderly patients with chronic obstructive pulmonary disease, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the effect of tiotropium bromide combined with budesonide formoterol on elderly patients with chronic obstructive pulmonary disease (COPD).
Methods Using the random number table method, the patients with COPD admitted to our hospital from January 2020 to November 2023 were divided into two groups: the control group received conventional treatment and used budesonide formoterol; the other group received the same treatment as the control group plus tiotropium bromide, serving as the experimental group. The blood gas analysis indicators, inflammation-related indicators, quality of life, clinical efficacy, and safety were compared between the two groups.
Results After treatment, arterial partial pressure of oxygen (PaO2), generic quality of life inventory 74 (GQOLI-74) scores in the experimental group increased, while partial pressure of carbon dioxide (PaCO2), interleukin-6 (IL-6), C-reactive protein (CRP) and procalcitonin (PCT) decreased, which were more significant than those in the control group(P<0.05). The experimental group’s overall efficacy rate was 98.33%, significantly better than the control group’s 80.00% (P<0.05). There was no statistically significant difference in adverse reactions between the experimental group (15.00%) and the control group (10.00%) (P>0.05).
Conclusion Tiotropium bromide in combination with budesonide formoterol can effectively regulate blood gas analysis and the level of inflammation, improve quality of life and enhance clinical efficacy.
, authors=Yu-xia LI, Fang WANG, Ya WU, authorsList=Yu-xia LI, Fang WANG, Ya WU, authorCompany=null, correspAuthors=Yu-xia LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704972241035271, articleId=1291704970026442757, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=噻托溴铵联合布地奈德福莫特罗在老年慢阻肺中的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究噻托溴铵剂型与布地奈德福莫特罗剂型对老年慢阻肺（COPD）患者联合应用的临床疗效和安全性。
方法 用随机数表法将本院2020年1月至2023年11月收治的COPD患者分为2组：接受常规治疗并使用布地奈德福莫特罗，作为对照组；另一组在对照组的治疗方案上额外使用噻托溴铵，作为试验组。比较2组血气分析指标、炎症相关指标、生活质量、临床疗效，并进行安全性评价。
结果 筛选脱落入组情况试验组治疗后动脉血氧分压（PaO2）、生活质量综合评定问卷（GQOLI-74）评分升高，二氧化碳分压（PaCO2）、白细胞介素-6（IL-6）、C反应蛋白（CRP）、降钙素原（PCT）下降，均较对照组更显著（P<0.05）；试验组总有效率（98.33%）高于对照组（80.00%）（P<0.05）；试验组不良反应（15.00%）与对照组（10.00%）比较差异无统计学意义（P>0.05）。
结论 应用噻托溴铵剂型联合布地奈德福莫特罗剂型可有效调节机体血气分析和炎症水平，提高生活质量，增强临床疗效。
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李钰霞（1987-），女，本科，主治医师，主要从事呼吸病学等方向研究
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