Article(id=1291704965618225831, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.19.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1742140800000, receivedDateStr=2025-03-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896062520, onlineDateStr=2026-08-05, pubDate=1760630400000, pubDateStr=2025-10-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896062520, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896062520, creator=13701087609, updateTime=1785896062520, updator=13701087609, issue=Issue{id=1291704892859638107, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='19', pageStart='2701', pageEnd='2850', issueExtLink='null', onlineDate='null', pubDate='1760630400000', pubDateStr='2025-10-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896045171, creator='13701087609', updateTime=1785896787712, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708007352656266, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708007352656267, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2701, endPage=2705, ext={EN=ArticleExt(id=1291704969183384232, articleId=1291704965618225831, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of betahistine mesylate combined with oxiracetam in treating posterior circulation ischemic vertigo, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the clinical efficacy of betahistine mesylate combined with oxiracetam in the treatment of patients with posterior circulation ischemic vertigo (PCIV).
Methods This prospective study included 80 patients with PCIV who were treated at our hospital between June 2022 and June 2024. The patients were randomly assigned into two groups: the observation group (40 cases, treated with betahistine combined with oxiracetam) and the control group (40 cases, treated with betahistine monotherapy). After two weeks of treatment, the following were assessed: vertigo symptom scores [Electronystagmography (ENG) score, Visual Vertigo Analogue Scale (VVAS), and Sheikh Control Scale (SCS)], imaging indicators, and serum-related factors.
Results After treatment, the nystagmogram score and Visual Vertigo Analog Scale (VVAS) score of the observation group were (3.08±0.86) and (37.13±3.26) points, respectively, which decreased significantly, while the Situational Vertigo Scale (SCS) score was (82.55±7.89) points, which increased significantly (P<0.05). The average blood flow velocities of the basilar artery and vertebral artery in the observation group were significantly higher than those in the control group (P<0.05). The serum levels of endothelin-1 (ET-1) and platelet-derived growth factor-BB (PDGF-BB) decreased, and the level of nerve growth factor (NGF) increased, with the observation group showing a better effect than the control group (P<0.05). The observation group experienced 2 cases of nausea and vomiting, 2 cases of rash, 2 cases of drowsiness, and 4 cases of dizziness, while the control group had 1 case of nausea and vomiting, 1 case of rash, and 1 case of dizziness, with no drowsiness reported. The incidence of adverse reactions was higher in the observation group than in the control group (χ2=4.501, P=0.034)(P<0.05).
Conclusion Betahistine mesylate combined with oxiracetam significantly improves symptoms in patients with PCIV, enhances hemodynamics, and modulates serum factors, demonstrating promising clinical application potential.
, authors=Rui-hong LIU
1, Yu-fan HE
2, Xiao-dong ZHANG
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目的 探讨甲磺酸倍他司汀片联合奥拉西坦注射液在治疗后循环缺血性眩晕患者中的临床疗效。
方法 选取2022年6月至2024年6月本院就诊的后循环缺血性眩晕患者，按随机数表法分为观察组（倍他司汀联合奥拉西坦）和对照组（倍他司汀单药治疗）。治疗2周后，观察眼震图积分、视觉性眩晕量表（VVAS）、Sheikh控制量表（SCS）、影像学指标和血清相关因子，并进行安全性评价。
结果 治疗后，观察组眼震图积分和VVAS评分分别为（3.08±0.86）、（37.13±3.26）分，显著降低，SCS评分为（82.55±7.89），显著升高（P<0.05）。观察组基底动脉及椎动脉平均血流速度显著高于对照组（P<0.05）。血清内皮素-1（ET-1）和血小板衍生生长因子-BB（PDGF-BB）水平降低，神经生长因子（NGF）水平升高，且观察组效果优于对照组（P<0.05）。观察组出现2例恶心呕吐、2例皮疹、2例嗜睡、4例头晕，对照组出现1例恶心呕吐、1例皮疹、1例头晕，无嗜睡出现。观察组不良反应发生率高于对照组（P<0.05）。
结论 甲磺酸倍他司汀片联合奥拉西坦注射液能显著改善后循环缺血性眩晕患者的症状，增强血流动力学，调节血清因子，具有良好的临床应用前景。
, authors=刘芮宏
1, 何雨繁
2, 张小东
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刘芮宏（1998-），女，硕士，医师，主要从事脑血管病、阿尔茨海默病方向研究
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