Article(id=1291704911872413824, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.18.021, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1745856000000, receivedDateStr=2025-04-29, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896049706, onlineDateStr=2026-08-05, pubDate=1758988800000, pubDateStr=2025-09-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896049706, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896049706, creator=13701087609, updateTime=1785896049706, updator=13701087609, issue=Issue{id=1291704811443999077, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='18', pageStart='2551', pageEnd='2700', issueExtLink='null', onlineDate='null', pubDate='1758988800000', pubDateStr='2025-09-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896025763, creator='13701087609', updateTime=1785896871490, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708358743053253, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708358743053254, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2692, endPage=2696, ext={EN=ArticleExt(id=1291704912115683457, articleId=1291704911872413824, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Considerations in clinical pharmacology research in the development of combination chemical drug, columnId=1291339025546211579, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Drug Evaluation and Administration, runingTitle=null, highlight=null, articleAbstract=

The research and development of combination chemical drug occupy an important position in the development of new drugs and generic drugs. Two or more active ingredients are often formulated into combined preparations for development based on clinical needs, the mechanism of drug action and actual clinical effects. In the research and development of combined chemical drugs, clinical pharmacology research serves as a crucial bridge connecting the theories of drug research and development and the practical application in clinical practice. Based on regulations and guidelines, this article explores the application of clinical pharmacology research in the research and development of combined pharmaceutical preparations by integrating research and development cases, clinical practice and literature research.

, authors=Fei-fei LIU, Dong LIU, Dong LI, Yu-zhu WANG, authorsList=Fei-fei LIU, Dong LIU, Dong LI, Yu-zhu WANG, authorCompany=null, correspAuthors=Yu-zhu WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704912518336642, articleId=1291704911872413824, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=化药复方药物研发中临床药理研究的一般考虑, columnId=1291339025730760957, journalTitle=中国临床药理学杂志, columnName=药物评价与管理, runingTitle=null, highlight=null, articleAbstract=

化药复方药物的研发在新药和仿制药研发中占据重要的地位。根据临床需要、药物作用机制及实际临床效应常将2种或2种以上活性成份组成复方制剂进行开发。在化药复方药物研发中，临床药理学研究是连接药物研发理论与临床实践应用的关键桥梁。本文根据法规和指导原则，结合研发案例，临床实践和文献调研等探讨临床药理研究在复方药物研发中的应用。

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刘霏霏（1987-），女，审评员，主要从事临床药理审评工作

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刘霏霏（1987-），女，审评员，主要从事临床药理审评工作

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