Article(id=1291704996198896478, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.18.017, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1742140800000, receivedDateStr=2025-03-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896069812, onlineDateStr=2026-08-05, pubDate=1758988800000, pubDateStr=2025-09-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896069812, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896069812, creator=13701087609, updateTime=1785896069812, updator=13701087609, issue=Issue{id=1291704811443999077, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='18', pageStart='2551', pageEnd='2700', issueExtLink='null', onlineDate='null', pubDate='1758988800000', pubDateStr='2025-09-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896025763, creator='13701087609', updateTime=1785896871490, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708358743053253, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708358743053254, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2667, endPage=2673, ext={EN=ArticleExt(id=1291704996387640159, articleId=1291704996198896478, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Meta-analysis of safety and efficacy of tranexamic acid in perioperative burn patients, columnId=1246531412438966969, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Reader’s Field, runingTitle=null, highlight=null, articleAbstract=
Objective The safety and efficacy of tranexamic acid in the perioperative period of burn patients remain controversial. This study aimed to investigate the safety and efficacy of tranexamic acid in perioperative burn patients.
Methods A systematic search was conducted in Pubmed, Embase, Cochrane Library, China national know-ledge infrastructure (CNKI), Wanfang, and other databases up to March 1, 2025, for studies on the use of tranexamic acid in perioperative burn care. The primary outcomes included total perioperative blood loss, perioperative blood transfusion events, operative time, all-cause mortality, and incidence of adverse events. Meta-analysis was performed using RevMan 5.4.1, with risk of bias assessed using Cochrane’s ROB 2 tool and Robins-1 tool.
Results Seven studies were included, comprising a total of 465 cases (218 in the tranexamic acid intervention group and 247 in the control group). The findings demonstrated that the total perioperative blood loss in the tranexamic acid group was significantly lower than in the control group [MD=-165.01, 95% confidence interval (CI) (-210.13 to -119.89), P<0.001]. Additionally, tranexamic acid reduced operative time [MD=-8.32, 95% CI (-14.55 to -2.09), P=0.009] and perioperative blood transfusion events (OR=0.26, 95% CI 0.15-0.44, P<0.001), without increasing all-cause mortality (OR=0.67, 95% CI 0.33 to 1.36, P=0.27).
Conclusion Tranexamic acid is effective in reducing total perioperative blood loss, shortening operative time, and decreasing the risk of perioperative blood transfusion events in burn patients, without increasing all-cause mortality. Thus, tranexamic acid can serve as a valuable adjunct in perioperative management for burn patients.
, authors=Jing SUN
1a, Chang MENG
1b, Yue ZHAO
1b, Ying BAI
1a, Shu-fang WANG
1b, Guo-bin MIAO
1b, authorsList=Jing SUN, Chang MENG, Yue ZHAO, Ying BAI, Shu-fang WANG, Guo-bin MIAO, authorCompany=null, correspAuthors=Guo-bin MIAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704996811264864, articleId=1291704996198896478, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=氨甲环酸在烧伤患者围术期应用安全性和有效性的Meta分析, columnId=1246531414020219657, journalTitle=中国临床药理学杂志, columnName=读者园地, runingTitle=null, highlight=null, articleAbstract=
目的 氨甲环酸在烧伤患者围术期应用的安全性和有效性尚存争议，本文旨在研究氨甲环酸在围术期应用的安全性和有效性。
方法 系统检索Pubmed、Embase、Cochrane Library、中国知网（CNKI）、万方等数据库涉及氨甲环酸在烧伤患者围术期的研究，检索时间截至2025年3月1日，评价指标包括围术期失血总量、围术期输血事件、手术时间、全因死亡率及不良事件发生率等。用RevMan 5.4.1进行Meta分析，根据Cochrane的ROB 2工具和Robins-1工具进行偏倚风险评估。
结果 最终纳入7篇研究，累计例数465例，其中氨甲环酸干预组218例，对照组247例。结果表明，氨甲环酸组围术期失血总量显著低于对照组[MD=-165.01，95%置信区间（CI）（-210.13～-119.89），P<0.001]，氨甲环酸可降低手术时间[MD=-8.32，95% CI（-14.55～-2.09），P=0.009]和围术期输血事件发生风险（OR=0.26，95% CI 0.15~0.44，P<0.001），并且氨甲环酸不增加全因死亡率（OR=0.67，95% CI 0.33~1.36，P=0.27）。
结论 氨甲环酸应用于围术期的烧伤患者可降低失血总量，缩短手术时间，降低围术期输血事件发生风险，不增加全因死亡率。氨甲环酸对于围术期烧伤患者可作为一种有价值的辅助手段。
, authors=孙晶
1a, 孟昌
1b, 赵月
1b, 白莹
1a, 王术芳
1b, 缪国斌
1b, authorsList=孙晶, 孟昌, 赵月, 白莹, 王术芳, 缪国斌, authorCompany=null, correspAuthors=缪国斌, authorNote=
孙晶（1987-），女，主治医师，主要从事急重症围术期管理的相关研究
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