Article(id=1291705022912422273, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.18.016, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1751385600000, receivedDateStr=2025-07-02, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896076181, onlineDateStr=2026-08-05, pubDate=1758988800000, pubDateStr=2025-09-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896076181, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896076181, creator=13701087609, updateTime=1785896076181, updator=13701087609, issue=Issue{id=1291704811443999077, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='18', pageStart='2551', pageEnd='2700', issueExtLink='null', onlineDate='null', pubDate='1758988800000', pubDateStr='2025-09-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896025763, creator='13701087609', updateTime=1785896871490, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708358743053253, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708358743053254, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2661, endPage=2666, ext={EN=ArticleExt(id=1291705023231189378, articleId=1291705022912422273, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Analysis of necrotic apoptosis-related lncRNAs expression levels in patients with hepatocellular carcinoma and construction of prognostic model based on TCGA database, columnId=1246531412438966969, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Reader’s Field, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the impact of necrotic apoptosis-related long non-coding RNA (lncRNA) on the prognosis of hepatocellular carcinoma (HCC) in high-risk populations.
Methods LncRNAs were identified by co-expression analysis of immune genes with gene expression and clinical data from the cancer genome atlas program (TCGA) database. A risk model was established through univariate and multivariate cox proportional hazards regression model (Cox), as well as Lasso regression analysis. Patients were screened from TCGA database and divided into high-risk group and low-risk group. Combined with necrotic apoptosis-related lncRNA features, a highly predictive nomogram was created.
Results By analyzing data from the TCGA, a total of five lncRNAs (TMCC1-AS1, AC026412.3, AC026356.1, AC100872.2, and FOXD2-AS1) were identified as potential biomarkers. Nomogram was created, and its predictive efficiency was assessed using a calibration curve. Receiver operating characteristic (ROC) curve analysis showed that the area under curve (AUC) for predicting 1-year, 3-year, and 5-year survival rate were 0.781, 0.663, and 0.686, respectively (P<0.001).
Conclusion Risk model constructed based on five necrotic apoptosis-related lncRNAs may predict prognosis in HCC patients.
, authors=Yan-qiu ZHU, Jun YANG, Wen-jun XU, Jin DUAN, Min JIA, Ying-min MA, Ping DU, authorsList=Yan-qiu ZHU, Jun YANG, Wen-jun XU, Jin DUAN, Min JIA, Ying-min MA, Ping DU, authorCompany=null, correspAuthors=Ping DU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291705023709340035, articleId=1291705022912422273, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于TCGA数据库分析肝细胞癌患者坏死性凋亡相关lncRNA表达并构建预后模型, columnId=1246531414020219657, journalTitle=中国临床药理学杂志, columnName=读者园地, runingTitle=null, highlight=null, articleAbstract=
目的 探讨坏死性凋亡相关长链非编码核糖核酸（lncRNA）对高危人群肝细胞癌（HCC）预后的影响。
方法 选取基因表达和临床数据来自癌症基因组图谱计划（TCGA）数据库的免疫基因进行共表达分析，鉴定lncRNA。通过单变量和多变量的比例风险回归模型（Cox）回归以及最小绝对收缩和选择算子（LASSO）回归分析，建立风险模型。选取TCGA数据库中的患者，分为高危组和低危组。通过结合坏死性凋亡相关lncRNA特征，创建具有高度预测性的列线图。
结果 通过分析TCGA数据集，TMCC1-AS1、AC026412.3、AC026356.1、AC100872.2和FOXD2-AS1共5个lncRNA被鉴定为潜在的生物标志物。构建列线图并生成校准曲线以评估预测性能。受试者工作特征曲线（ROC）预测1年、3年和5年生存率的曲线下面积（AUC）分别为0.781、0.663和0.686（P<0.001）。
结论 基于5个坏死性凋亡相关lncRNA构建的风险模型可能预测HCC患者的预后。
, authors=祝艳秋, 杨君, 许文君, 段瑾, 贾敏, 马迎民, 杜萍, authorsList=祝艳秋, 杨君, 许文君, 段瑾, 贾敏, 马迎民, 杜萍, authorCompany=null, correspAuthors=杜萍, authorNote=
祝艳秋（1990-），女，主管药师，主要从事药理学及临床药学研究
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=iF+5tfu8QjGkm4+6fHZaxQ==, magXml=tUN86pAmdJNll0sIMZQmTA==, pdfUrl=null, pdf=VSOYUEtD1GEJzNdT56lEWw==, pdfFileSize=1480559, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=bIJeZhIMbIMfgCBhGcZ6TA==, mapNumber=null, fund=null)}, authors=[Author(id=1291705024011329928, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291705024082633098, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705024011329928, language=EN, stringName=Yan-qiu ZHU, firstName=Yan-qiu, middleName=null, lastName=ZHU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291705024149741963, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705024011329928, language=CN, stringName=祝艳秋, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069, bio={"content":"
祝艳秋（1990-），女，主管药师，主要从事药理学及临床药学研究
"}, bioImg=null, bioContent=
祝艳秋（1990-），女，主管药师，主要从事药理学及临床药学研究
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291705023931638148, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, xref=null, ext=[AuthorCompanyExt(id=1291705023940026757, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China), AuthorCompanyExt(id=1291705023948415366, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069)])]), Author(id=1291705025802297741, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291705025902961039, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705025802297741, language=EN, stringName=Jun YANG, firstName=Jun, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291705025970069904, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705025802297741, language=CN, stringName=杨君, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291705023931638148, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, xref=null, ext=[AuthorCompanyExt(id=1291705023940026757, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China), AuthorCompanyExt(id=1291705023948415366, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069)])]), Author(id=1291705026045567378, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291705026129453460, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705026045567378, language=EN, stringName=Wen-jun XU, firstName=Wen-jun, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291705026200756629, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705026045567378, language=CN, stringName=许文君, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291705023931638148, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, xref=null, ext=[AuthorCompanyExt(id=1291705023940026757, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China), AuthorCompanyExt(id=1291705023948415366, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069)])]), Author(id=1291705026276254103, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291705026351751577, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705026276254103, language=EN, stringName=Jin DUAN, firstName=Jin, middleName=null, lastName=DUAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291705026427249050, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705026276254103, language=CN, stringName=段瑾, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291705023931638148, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, xref=null, ext=[AuthorCompanyExt(id=1291705023940026757, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China), AuthorCompanyExt(id=1291705023948415366, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069)])]), Author(id=1291705026494357916, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291705026569855390, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705026494357916, language=EN, stringName=Min JIA, firstName=Min, middleName=null, lastName=JIA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291705026636964255, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705026494357916, language=CN, stringName=贾敏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291705023931638148, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, xref=null, ext=[AuthorCompanyExt(id=1291705023940026757, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China), AuthorCompanyExt(id=1291705023948415366, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069)])]), Author(id=1291705026716656033, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291705026787959203, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705026716656033, language=EN, stringName=Ying-min MA, firstName=Ying-min, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291705026859262372, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705026716656033, language=CN, stringName=马迎民, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291705023931638148, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, xref=null, ext=[AuthorCompanyExt(id=1291705023940026757, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China), AuthorCompanyExt(id=1291705023948415366, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069)])]), Author(id=1291705026938954150, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=pingdu2012@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291705027006063016, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705026938954150, language=EN, stringName=Ping DU, firstName=Ping, middleName=null, lastName=DU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291705027073171881, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, authorId=1291705026938954150, language=CN, stringName=杜萍, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291705023931638148, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, xref=null, ext=[AuthorCompanyExt(id=1291705023940026757, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China), AuthorCompanyExt(id=1291705023948415366, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069)])])], keywords=[Keyword(id=1291705027161252266, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, language=EN, orderNo=1, keyword=necroptosis), Keyword(id=1291705027228361131, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, language=EN, orderNo=2, keyword=long non-coding RNA), Keyword(id=1291705027287081388, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, language=EN, orderNo=3, keyword=hepatocellular carcinoma), Keyword(id=1291705027349995949, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, language=EN, orderNo=4, keyword=prognosis), Keyword(id=1291705027425493422, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, language=CN, orderNo=1, keyword=坏死性凋亡), Keyword(id=1291705027484213679, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, language=CN, orderNo=2, keyword=长链非编码核糖核酸), Keyword(id=1291705027547128240, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, language=CN, orderNo=3, keyword=肝细胞癌), Keyword(id=1291705027614237105, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, language=CN, orderNo=4, keyword=预后)], refs=null, funds=[Fund(id=1291705027710706098, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, awardId=2025Y-HZ-01, language=CN, fundingSource=北京肝病研究所自主选题院所合作项目(2025Y-HZ-01), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1291705023931638148, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, xref=null, ext=[AuthorCompanyExt(id=1291705023940026757, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Drug Clinical Trial Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China), AuthorCompanyExt(id=1291705023948415366, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291705022912422273, companyId=1291705023931638148, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=首都医科大学 附属北京佑安医院 国家药物临床试验机构，北京，100069)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1788948995538, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509895005466898, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995591, updatedTime=1788948995591, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1304509895047409939, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995601, updatedTime=1788948995601, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.18.016, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.18.016, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.18.016, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.18.016, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1758988800000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
128
24
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
