Article(id=1291704981778879212, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.18.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1749657600000, receivedDateStr=2025-06-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896066373, onlineDateStr=2026-08-05, pubDate=1758988800000, pubDateStr=2025-09-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896066373, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896066373, creator=13701087609, updateTime=1785896066373, updator=13701087609, issue=Issue{id=1291704811443999077, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='18', pageStart='2551', pageEnd='2700', issueExtLink='null', onlineDate='null', pubDate='1758988800000', pubDateStr='2025-09-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896025763, creator='13701087609', updateTime=1785896871490, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708358743053253, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708358743053254, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2630, endPage=2634, ext={EN=ArticleExt(id=1291704981996983021, articleId=1291704981778879212, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of atrosiban acetate combined with magnesium sulfate in inhibiting uterine contractions in premature delivery, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To study the clinical effect and safety of atosiban acetate injection combined with magnesium sulfate injection in inhibiting uterine contractions in premature delivery.
Methods Patients with threatened preterm delivery were divided into treatment group (treated with atosiban acetate combined with magnesium sulfate) and control group (treated with magnesium sulfate) by random number table method. The 24 h dose magnesium sulfate injection was 30 g and this drug was stopped when uterine contraction was inhibited, the total dose of atosiban acetate injection was ≤ 330 mg and total treatment time should not exceed 48 h. The effects of contraction inhibition, serological indexes, hemodynamics, safety and perinatal outcomes of the two groups were compared.
Results A total of 97 cases were screened in this study, there were 47 cases in control group and 45 cases in treatment group. The treatment group and control group with success rate of fetal protection were 97.78% and 82.98%, the extended gestation time was (26.35±4.12) and (20.04±3.27) d, and the onset time of uterine contraction was (1.58±0.26) and (2.45±0.38) h, and the difference was all statistically significant (all P<0.05). After treatment, the interleukin-6 (IL-6) levels in treatment group and control group were (142.34±15.75) and (182.17±19.43) ng·L-1, respectively. Matrix metalloproteinase inhibitor-1 (TIMP-1) was (135.29±15.42) and (112.48±13.55) pg·mL-1, nitric oxide (NO) was (23.03±2.17) and (28.13±3.01) μmol·L-1; and the difference of the indexes between two groups was statistically significant (P<0.05). After treatment, there were no statistically significant differences in systolic blood pressure (SBP)[(120.07±13.97) vs. (119.28±13.51) mmHg], heart rate (HR)[(93.56±10.82) vs. (93.32±10.65) bpm] and diastolic blood pressure (DBP) [(77.22±9.05) vs. (78.32±9.47) mmHg] between 2 groups (P>0.05). There were no statistically differences in perinatal mortality and incidence of adverse reactions in 2 groups (P>0.05). The incidence of neonatal asphyxia in treatment group and control group was 2.22% and 17.02%, and the incidence of low body weight infants was 2.22% and 14.89%, the difference was statistically significant (P<0.05).
Conclusion Atosiban acetate injection combined with magnesium sulfate injection can effectively inhibit uterine contraction, reduce inflammation, improve vascular endothelial function, regulate serum TIMP-1 expression, and improve perinatal outcomes in patients with threatened preterm delivery, with good safety and no significant effects on hemodynamics.
, authors=Jing ZHAO, Zhi-fei REN, Gao-yan JIA, Guang-yi Zhang, authorsList=Jing ZHAO, Zhi-fei REN, Gao-yan JIA, Guang-yi Zhang, authorCompany=null, correspAuthors=Guang-yi Zhang, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704982349304558, articleId=1291704981778879212, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=醋酸阿托西班联合硫酸镁对早产抑制宫缩的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 研究醋酸阿托西注射液班联合硫酸镁注射液对早产抑制宫缩的临床疗效和安全性。
方法 把先兆早产患者以随机数表法分为试验组（接受醋酸阿托西班联合硫酸镁治疗）和对照组（接受硫酸镁治疗）。硫酸镁注射液24 h总量为30 g，宫缩停止发作时停止用药；醋酸阿托班注射液总治疗剂量≤330 mg，总治疗时间≤48 h。对比2组的宫缩抑制效果、血清学指标、血流动力学及围产儿结局并进行安全性评价。
结果 本研究共筛选97例，对照组入组47例，试验组入组45例。试验组和对照组保胎成功率分别为97.78%和82.98%，延长妊娠时间分别为（26.35±4.12）和（20.04±3.27）d，宫缩起效时间分别为（1.58±0.26）和（2.45±0.38）h，在统计学上差异均有统计学意义（均P<0.05）。治疗后，试验组和对照组的白细胞介素-6（IL-6）分别为（142.34±15.15）和（182.17±19.43）ng·L-1，基质金属蛋白酶抑制剂-1（TIMP-1）分别为（135.29±15.42）和（112.48±13.55）pg·mL-1，一氧化氮（NO）分别为（23.03±2.17）和（28.13±3.01）μmol·L-1，试验组的上述指标与对照组比较，在统计学上差异有统计学意义（P<0.05）。治疗后，2组的收缩压（SBP）分别为（120.07±13.97）和（119.28±13.15）mmHg、心率（HR）分别为每分钟（93.56±10.82）和（93.32±10.65）次，以及舒张压（DBP）分别为（77.22±9.05）和（78.32±9.47）mmHg，上述指标2组比较在统计学上差异无统计学意义（均P>0.05）。试验组和对照组的围产儿死亡率分别为0.00%和6.38%，药物不良反应发生率分别为13.33%和10.64%。2组围产儿死亡率以及药物不良反应发生率比较，在统计学上差异均无统计学意义（均P>0.05）。试验组和对照组新生儿窒息发生率分别为2.22%和17.02%，低体重儿发生率分别为2.22%和14.89%，在统计学上差异有统计学意义（P<0.05）。
结论 醋酸阿托西班注射液联合硫酸镁注射液可有效抑制先兆早产患者宫缩，减轻炎症反应，改善血管内皮功能，调节血清TIMP-1表达，改善围产儿结局，安全性良好，且对患者血流动力学无明显影响。
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赵静（1979-），女，副主任医师，主要从事产科临床诊疗方面的工作
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