Article(id=1291704839696831027, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.18.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1746892800000, receivedDateStr=2025-05-11, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896032499, onlineDateStr=2026-08-05, pubDate=1758988800000, pubDateStr=2025-09-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896032499, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896032499, creator=13701087609, updateTime=1785896032499, updator=13701087609, issue=Issue{id=1291704811443999077, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='18', pageStart='2551', pageEnd='2700', issueExtLink='null', onlineDate='null', pubDate='1758988800000', pubDateStr='2025-09-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896025763, creator='13701087609', updateTime=1785896871490, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708358743053253, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708358743053254, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2624, endPage=2629, ext={EN=ArticleExt(id=1291704839914934836, articleId=1291704839696831027, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical study of propofol combined with sufentanil for intravenous anesthesia in children undergoing laparoscopic repair of oblique inguinal hernia, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe clinical curative effect and safety of propofol emulsion injection combined with sufentanil citrate injection for intravenous anesthesia in children undergoing laparoscopic repair of oblique inguinal hernia.
Methods According to historical medication regimens, children undergoing laparoscopic repair of oblique inguinal hernia were divided into treatment group and control group. The control group was given intravenous pumping of propofol emulsion injection 4-10 mg·kg-1·h-1 and fentanyl citrate injection 3 μg·kg-1·h-1 for anesthesia maintenance, while treatment group was given intravenous pumping of propofol emulsion injection 4-10 mg·kg-1·h-1 and sufentanil citrate injection 0.3 μg·kg-1·h-1 for anesthesia maintenance. The hemodynamic indexes, emergence agitation, awakening quality, pain and postoperative analgesics use were compared between the two groups at different time points, and safety evaluation was performed.
Results According to electronic medical record, 427 children with oblique inguinal hernia were enrolled between June 2021 and 2024. Finally, 160 cases meeting the inclusion and exclusion criteria were included for grouping analysis, including 76 cases in control group and 84 cases in treatment group. Immediately after skin incision (T1), heart rate (HR) in treatment group and control group were (92.67±5.06) and (97.53±4.97) time·min-1, and mean arterial pressure (MAP) were (98.63±5.82) and (101.31±5.49) mmHg, respectively. At 5 min after the start of surgery (T2), HR in treatment group and control group were (89.35±5.22) and (94.21±5.36) time·min-1, and MAP were (96.97±5.13) and (99.29±4.75) mmHg, respectively. After the surgery (T3), HR in treatment group and control group were (87.41±4.89) and (89.82±4.61) time·min-1, and MAP were (93.82±5.67) and (96.71±5.03) mmHg, respectively. The incidences of emergence agitation in treatment group and control group were 3.57% (3 cases/84 cases) and 11.84% (9 cases/76 cases), awakening time were (8.21±1.76) and (10.45±2.59) min, recovery time of spontaneous respiration were (6.29±1.40) and (8.63±2.02) min, and extubation time were (12.43±2.51) and (15.87±3.08) min, respectively; immediately after awakening, scores of the face, legs, activity, cry, consolability behavioral tool (FLACC) in treatment group and control group were (2.08±0.59) and (2.43±0.65) points; at 1 h after awakening, FLACC scores were (1.75±0.47) and (2.12±0.61) points; at 6 h after awakening, FLACC scores were (1.42±0.41) and (1.73±0.49); at 12 h after awakening, FLACC scores were (1.28±0.36) and (1.56±0.43) points, and differences in the above indexes between the two groups were statistically significant (all P<0.05). The total dosages of postoperative analgesics in treatment group and control group were (33.51±3.21) and (41.98±3.94) mL, and compression frequency of analgesic pump was (1.55±0.42) and (2.89±0.75) times, the differences were statistically significant (all P<0.05). The adverse drug reactions were as follows: treatment group: nausea, hypotension, vomiting, dizziness; control group: nausea, hypotension, vomiting, dizziness. There was no significant difference in total incidence of adverse drug reactions between treatment group and control group [10.71% (9 cases/84 cases) vs. 9.21% (7 cases/76 cases), (P>0.05)].
Conclusion Compared with propofol emulsion injection combined with fentanyl citrate injection, propofol emulsion injection combined with sufentanil citrate injection for intravenous anesthesia is beneficial to maintain hemodynamic stability, improve emergence agitation and awakening quality, relieve postoperative pain and reduce postoperative use of analgesics in children undergoing laparoscopic repair of oblique inguinal hernia, which has good safety.
, authors=Ping HAN, Rui-chao CHU, Yan ZHANG, authorsList=Ping HAN, Rui-chao CHU, Yan ZHANG, authorCompany=null, correspAuthors=Yan ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704840409862709, articleId=1291704839696831027, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=舒芬太尼联合丙泊酚静脉麻醉在小儿腹腔镜下腹股沟斜疝修补术的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察丙泊酚乳状注射液联合枸橼酸舒芬太尼注射液静脉麻醉用于小儿腹腔镜下腹股沟斜疝修补术麻醉的临床疗效和安全性。
方法 将行腹腔镜下腹股沟斜疝修补术的患儿按历史用药方案自然分组，分为试验组和对照组。对照组静脉泵注丙泊酚乳状注射液4~10 mg·kg-1·h-1、枸橼酸芬太尼注射液3 μg·kg-1·h-1进行麻醉维持。试验组静脉泵注丙泊酚乳状注射液4~10 mg·kg-1·h-1、枸橼酸舒芬太尼注射液0.3 μg·kg-1·h-1进行麻醉维持。比较2组不同时刻的血流动力学指标、苏醒期躁动情况、苏醒质量、疼痛情况、术后镇痛药物使用情况，并进行安全性评价。
结果 通过电子病历系统筛选2021年月6至2024年6月收治的腹股沟斜疝患儿427例，最终纳入符合入排标准的160例进行分组分析，对照组76例、试验组84例。切皮时（T1），试验组及对照组的心率（HR）分别为（92.67±5.06）和（97.53±4.97）time·min-1，平均动脉压（MAP）分别为（98.63±5.82）和（101.31±5.49）mmHg；手术5 min时（T2），试验组及对照组的HR分别为（89.35±5.22）和（94.21±5.36）time·min-1，MAP分别为（96.97±5.13）和（99.29±4.75）mmHg；术毕时（T3），试验组及对照组的HR分别为（87.41±4.89）和（89.82±4.61）time·min-1，MAP分别为（93.82±5.67）和（96.71±5.03）mmHg；试验组及对照组的苏醒期躁动发生率分别为3.57%（3例/84例）和11.84%（9例/76例），苏醒时间分别为（8.21±1.76）和（10.45±2.59）min，自主呼吸恢复时间分别为（6.29±1.40）和（8.63±2.02）min，气管拔管时间分别为（12.43±2.51）和（15.87±3.08）min；苏醒即刻，试验组和对照组的儿童疼痛行为量表（FLACC）评分分别为（2.08±0.59）和（2.43±0.65）分；苏醒1 h，FLACC分别为（1.75±0.47）和（2.12±0.61）分；苏醒6 h，FLACC分别为（1.42±0.41）和（1.73±0.49）分；苏醒12 h，FLACC分别为（1.28±0.36）和（1.56±0.43）分，上述指标在试验组和对照组间比较，在统计学上差异均有统计学意义（均P<0.05）。试验组和对照组术后镇痛药物使用总量分别为（33.51±3.21）和（41.98±3.94）mL，镇痛泵按压次数分别为（1.55±0.42）和（2.89±0.75）次，在统计学上差异均有统计学意义（均P<0.05）。试验组的药物不良反应有恶心、低血压、呕吐、眩晕；对照组的药物不良反应有恶心、低血压、呕吐、眩晕，试验组和对照组的药物不良反应总发生率分别为10.71%（9例/84例）和9.21%（7例/76例），在统计学上差异无统计学意义（P>0.05）。
结论 腹腔镜下腹股沟斜疝修补术患儿用丙泊酚乳状注射液联合枸橼酸舒芬太尼注射液静脉麻醉与丙泊酚乳状注射液联合枸橼酸芬太尼注射液相比，有利于维持血流动力学稳定，改善苏醒期躁动情况，提高苏醒质量，缓解术后疼痛，减少术后镇痛药物使用，且安全性良好。
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韩平（1976-），女，副主任医师，主要从事小儿麻醉方面的临床工作和研究
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