首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1291704867584762111, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.18.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1745769600000, receivedDateStr=2025-04-28, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896039147, onlineDateStr=2026-08-05, pubDate=1758988800000, pubDateStr=2025-09-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896039147, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896039147, creator=13701087609, updateTime=1785896039147, updator=13701087609, issue=Issue{id=1291704811443999077, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='18', pageStart='2551', pageEnd='2700', issueExtLink='null', onlineDate='null', pubDate='1758988800000', pubDateStr='2025-09-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896025763, creator='13701087609', updateTime=1785896871490, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708358743053253, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708358743053254, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2605, endPage=2610, ext={EN=ArticleExt(id=1291704869396701440, articleId=1291704867584762111, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical study of icotinib in the treatment of patients with recurrent mediastinal squamous cell carcinoma, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective

To observe the clinical efficacy and safety of icotinib in the treatment of patients with recurrent mediastinal squamous cell carcinoma.

Methods

Patients with recurrent mediastinal squamous cell carcinoma were randomly divided into control group and treatment group using a random number table. Control group received docetaxel injection 75 mg·m-2, intravenous infusion, once every 3 weeks for 4 cycles; treatment group received icotinib 150 mg, orally, 3 times daily for 12 consecutive weeks. The clinical efficacy, disease control rate, progression-free survival, quality of life scores, physiological laboratory indicators and the incidence of adverse drug reactions were compared between the two groups.

Results

A total of 105 patients were enrolled, 3 cases were excluded during the trial, leaving 52 participants in treatment group and 50 in control group. After treatment, the objective response rates (ORR) for treatment group and control group were 42.31% (22 cases /52 cases) and 32.00% (16 cases /50 cases); the disease control rates (DCR) were 76.92% (40 cases/52 cases) and 60.00% (30 cases/50 cases); the median progression-free survival (PFS) were 5.60 and 4.20 months; the median overall survival (OS) were 16.90 and 10.50 months; the overall health status were (72.61±13.96) and (63.62±16.94) points, respectively; the functional scale scores were (80.19±15.73) and (68.39±14.55) points, respectively; the symptom scale scores were (31.41±12.61) and (41.81±10.57) points, respectively; white blood cell count (WBC) were (2.31±1.50) and (4.45±1.00)×109 cell·L-1 ; neutrophil count (NEU) were (3.70±1.38) and (1.96±0.95)×109 cell·L-1; hemoglobin (Hb) were (119.39±17.40) and (109.98±14.04) g·L-1; platelet count (PLT) were (217.68±50.33) and (164.93±56.01)×109 cell·L-1. Compared with control group, the above indexes in treatment group all had significant differences (all P<0.05). The main adverse drug reactions in treatment group were rash, diarrhea and elevated transaminase; in control group were bone marrow suppression, alopecia, nausea and vomiting . There was no significant difference in the total incidence of adverse drug reactions between the two groups (82.69% vs. 90.00%, P>0.05). However, the incidence of grade 3-4 adverse drug reactions in treatment group was significantly lower than that in control group (11.54% vs. 30.00%, P<0.05).

Conclusion

Icotinib tablet is more effective than docetaxel injection in treating recurrent mediastinal squamous cell carcinoma, with less hematological toxicity, lower incidence of severe adverse reactions, and better safety profile.

, authors=De-jun SHU1, Yu-guang SHEN1, Ji-yang TANG1, Wei-fu ZHOU1, Xun LU1, Yong MEI2, authorsList=De-jun SHU, Yu-guang SHEN, Ji-yang TANG, Wei-fu ZHOU, Xun LU, Yong MEI, authorCompany=null, correspAuthors=Yu-guang SHEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704870524969217, articleId=1291704867584762111, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=埃克替尼治疗纵隔复发性鳞状细胞癌患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的

观察埃克替尼片治疗纵隔复发性鳞状细胞癌的临床疗效和安全性。

方法

将纵隔复发性鳞状细胞癌患者按随机数表法分为对照组和试验组。对照组给予多西他赛注射液75 mg·m-2静脉滴注，每3周1次，共4个疗程；试验组给予埃克替尼片150 mg，口服，每日3次，连续用药12周。比较2组患者的临床疗效、疾病控制率、无进展生存期、生活质量评分和生理学实验室指标，并进行安全性评价。

结果

共纳入105例受试者，试验过程中共脱落3例，最终试验组和对照组分别纳入52例和50例。治疗后，试验组和对照组的总有效率（ORR）分别为42.31%（22例/52例）和32.00%（16例/50例）；疾病控制率（DCR）分别为76.92%（40例/52例）和60.00%（30例/50例）；中位无进展生存期（PFS）分别为5.60个月和4.20个月；中位总生存期（OS）分别为16.90个月和10.50个月；总体健康状况评分分别为（72.61±13.96）和（63.62±16.94）分；功能量表评分分别为（80.19±15.73）和（68.39±14.55）分；症状量表评分分别为（31.41±12.61）和（41.81±10.57）分；白细胞计数（WBC）分别为（2.31±1.50）和（4.45±1.00）×109·L-1；中性粒细胞计数（NEU）分别为（3.70±1.38）和（1.96±0.95）×109·L-1；血红蛋白（Hb）分别为（119.39±17.40）和（109.98±14.04）g·L-1；血小板计数（PLT）分别为（217.68±50.33）和（164.93±56.01）×109·L-1，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（均P<0.05）。试验组的药物不良反应主要有皮疹、腹泻和转氨酶升高，对照组的药物不良反应主要有骨髓抑制、脱发和恶心呕吐。试验组和对照组的总药物不良反应发生率分别为82.69%和90.00%，在统计学上差异无统计学意义（P>0.05），但试验组3 ~ 4级药物不良反应发生率显著低于对照组（11.54% vs. 30.00%，P<0.05）。

结论

与多西他赛注射液比较，埃克替尼片治疗纵隔复发性鳞状细胞癌的疗效更佳，且对血液系统毒性更小，重度药物不良反应发生率更低，安全性更好。

, authors=舒德军1, 沈玉光1, 唐激扬1, 周维富1, 卢勋1, 梅永2, authorsList=舒德军, 沈玉光, 唐激扬, 周维富, 卢勋, 梅永, authorCompany=null, correspAuthors=沈玉光, authorNote=

舒德军（1986-），男，硕士研究生，主治医师，主要从事胸外科疾病相关临床工作和研究

, correspAuthorsNote=
沈玉光，主任医师，硕士生导师 MP: 13595259966 E-mail:
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=OwFlod3q6N2nYLFw3SsJOA==, magXml=tHy/KlShvSKTzjAFgCbGyw==, pdfUrl=null, pdf=5wzPM8yj/IMKuHfb6Qcswg==, pdfFileSize=1088616, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=/1xYb7ZTeIxPuWW/NTr2Zw==, mapNumber=null, fund=null)}, authors=[Author(id=1291704873960104204, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704874308231438, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704873960104204, language=EN, stringName=De-jun SHU, firstName=De-jun, middleName=null, lastName=SHU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704874387923215, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704873960104204, language=CN, stringName=舒德军, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000, bio={"content":"

舒德军（1986-），男，硕士研究生，主治医师，主要从事胸外科疾病相关临床工作和研究

"}, bioImg=null, bioContent=

舒德军（1986-），男，硕士研究生，主治医师，主要从事胸外科疾病相关临床工作和研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704871808426243, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=1., ext=[AuthorCompanyExt(id=1291704871829397764, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China), AuthorCompanyExt(id=1291704872169136389, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000)])]), Author(id=1291704874740244753, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=1120008146@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291704874824130835, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704874740244753, language=EN, stringName=Yu-guang SHEN, firstName=Yu-guang, middleName=null, lastName=SHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704875163869460, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704874740244753, language=CN, stringName=沈玉光, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704871808426243, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=1., ext=[AuthorCompanyExt(id=1291704871829397764, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China), AuthorCompanyExt(id=1291704872169136389, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000)])]), Author(id=1291704875235172630, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704875591688472, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704875235172630, language=EN, stringName=Ji-yang TANG, firstName=Ji-yang, middleName=null, lastName=TANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704875658797337, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704875235172630, language=CN, stringName=唐激扬, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704871808426243, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=1., ext=[AuthorCompanyExt(id=1291704871829397764, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China), AuthorCompanyExt(id=1291704872169136389, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000)])]), Author(id=1291704876032090395, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704876376023325, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704876032090395, language=EN, stringName=Wei-fu ZHOU, firstName=Wei-fu, middleName=null, lastName=ZHOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704876480880926, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704876032090395, language=CN, stringName=周维富, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704871808426243, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=1., ext=[AuthorCompanyExt(id=1291704871829397764, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China), AuthorCompanyExt(id=1291704872169136389, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000)])]), Author(id=1291704876782870816, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704878288625954, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704876782870816, language=EN, stringName=Xun LU, firstName=Xun, middleName=null, lastName=LU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704878368317731, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704876782870816, language=CN, stringName=卢勋, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704871808426243, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=1., ext=[AuthorCompanyExt(id=1291704871829397764, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China), AuthorCompanyExt(id=1291704872169136389, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000)])]), Author(id=1291704878452203813, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704878573838631, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704878452203813, language=EN, stringName=Yong MEI, firstName=Yong, middleName=null, lastName=MEI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704878666113320, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704878452203813, language=CN, stringName=梅永, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.贵州医科大学 附属医院 肝胆外科，贵州 贵阳 550001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704873859440904, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=2., ext=[AuthorCompanyExt(id=1291704873867829513, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704873859440904, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China), AuthorCompanyExt(id=1291704873876218122, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704873859440904, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.贵州医科大学 附属医院 肝胆外科，贵州 贵阳 550001)])])], keywords=[Keyword(id=1291704878997463337, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, language=EN, orderNo=1, keyword=icotinib tablet), Keyword(id=1291704879089738026, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, language=EN, orderNo=2, keyword=docetaxel injection), Keyword(id=1291704879299453227, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, language=EN, orderNo=3, keyword=recurrent mediastinal squamous cell carcinoma), Keyword(id=1291704879370756396, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, language=EN, orderNo=4, keyword=clinical efficacy), Keyword(id=1291704879463031085, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, language=EN, orderNo=5, keyword=adverse reactions), Keyword(id=1291704879714689326, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, language=CN, orderNo=1, keyword=埃克替尼片), Keyword(id=1291704879798575407, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, language=CN, orderNo=2, keyword=多西他赛注射液), Keyword(id=1291704879886655792, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, language=CN, orderNo=3, keyword=纵隔复发性鳞状细胞癌), Keyword(id=1291704879953764657, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, language=CN, orderNo=4, keyword=临床疗效), Keyword(id=1291704880134119730, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, language=CN, orderNo=5, keyword=药物不良反应)], refs=null, funds=[Fund(id=1291704880251560243, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, awardId=黔科合基础-[2024]青年268号, language=CN, fundingSource=贵州省科技计划基金资助项目(黔科合基础-[2024]青年268号), fundOrder=null, country=null), Fund(id=1291704880314474805, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, awardId=遵市科合HZ字（2021）272号, language=CN, fundingSource=贵州省遵义市科技局科技计划基金资助项目(遵市科合HZ字（2021）272号), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1291704871808426243, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=1., ext=[AuthorCompanyExt(id=1291704871829397764, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China), AuthorCompanyExt(id=1291704872169136389, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000)]), AuthorCompany(id=1291704873859440904, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=2., ext=[AuthorCompanyExt(id=1291704873867829513, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704873859440904, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China), AuthorCompanyExt(id=1291704873876218122, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704873859440904, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.贵州医科大学 附属医院 肝胆外科，贵州 贵阳 550001)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1788948995538, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509895005466898, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995591, updatedTime=1788948995591, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1304509895047409939, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995601, updatedTime=1788948995601, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.18.006, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.18.006, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.18.006, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.18.006, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1758988800000, fullTextJson=null, articleText=null, reference=null)
收藏切换
埃克替尼治疗纵隔复发性鳞状细胞癌患者的临床研究
收藏切换
PDF下载
舒德军 1 , 沈玉光 1 , 唐激扬 1 , 周维富 1 , 卢勋 1 , 梅永 2
中国临床药理学杂志 | 临床与基础桥接研究 2025,41(18): 2605-2610
收起
收藏切换
中国临床药理学杂志 |临床与基础桥接研究 2025 , 41 (18) : 2605 -2610
埃克替尼治疗纵隔复发性鳞状细胞癌患者的临床研究
全屏
[Author(id=1291704873960104204, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704874308231438, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704873960104204, language=EN, stringName=De-jun SHU, firstName=De-jun, middleName=null, lastName=SHU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704874387923215, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704873960104204, language=CN, stringName=舒德军, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000, bio={"content":"

舒德军（1986-），男，硕士研究生，主治医师，主要从事胸外科疾病相关临床工作和研究

"}, bioImg=null, bioContent=

舒德军（1986-），男，硕士研究生，主治医师，主要从事胸外科疾病相关临床工作和研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704871808426243, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=1., ext=[AuthorCompanyExt(id=1291704871829397764, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China), AuthorCompanyExt(id=1291704872169136389, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000)])]), Author(id=1291704874740244753, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=1120008146@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291704874824130835, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704874740244753, language=EN, stringName=Yu-guang SHEN, firstName=Yu-guang, middleName=null, lastName=SHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704875163869460, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704874740244753, language=CN, stringName=沈玉光, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704871808426243, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=1., ext=[AuthorCompanyExt(id=1291704871829397764, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China), AuthorCompanyExt(id=1291704872169136389, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000)])]), Author(id=1291704875235172630, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704875591688472, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704875235172630, language=EN, stringName=Ji-yang TANG, firstName=Ji-yang, middleName=null, lastName=TANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704875658797337, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704875235172630, language=CN, stringName=唐激扬, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704871808426243, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=1., ext=[AuthorCompanyExt(id=1291704871829397764, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China), AuthorCompanyExt(id=1291704872169136389, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000)])]), Author(id=1291704876032090395, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704876376023325, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704876032090395, language=EN, stringName=Wei-fu ZHOU, firstName=Wei-fu, middleName=null, lastName=ZHOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704876480880926, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704876032090395, language=CN, stringName=周维富, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704871808426243, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=1., ext=[AuthorCompanyExt(id=1291704871829397764, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China), AuthorCompanyExt(id=1291704872169136389, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000)])]), Author(id=1291704876782870816, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704878288625954, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704876782870816, language=EN, stringName=Xun LU, firstName=Xun, middleName=null, lastName=LU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704878368317731, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704876782870816, language=CN, stringName=卢勋, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704871808426243, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=1., ext=[AuthorCompanyExt(id=1291704871829397764, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China), AuthorCompanyExt(id=1291704872169136389, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704871808426243, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000)])]), Author(id=1291704878452203813, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704878573838631, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704878452203813, language=EN, stringName=Yong MEI, firstName=Yong, middleName=null, lastName=MEI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704878666113320, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, authorId=1291704878452203813, language=CN, stringName=梅永, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.贵州医科大学 附属医院 肝胆外科，贵州 贵阳 550001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704873859440904, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, xref=2., ext=[AuthorCompanyExt(id=1291704873867829513, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704873859440904, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China), AuthorCompanyExt(id=1291704873876218122, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704867584762111, companyId=1291704873859440904, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.贵州医科大学 附属医院 肝胆外科，贵州 贵阳 550001)])])]
舒德军1, 沈玉光1 , 唐激扬1, 周维富1, 卢勋1, 梅永2
作者信息
  • 1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000
  • 2.贵州医科大学 附属医院 肝胆外科，贵州 贵阳 550001
通讯作者:
沈玉光，主任医师，硕士生导师 MP: 13595259966 E-mail:
作者简介:

舒德军（1986-），男，硕士研究生，主治医师，主要从事胸外科疾病相关临床工作和研究

Clinical study of icotinib in the treatment of patients with recurrent mediastinal squamous cell carcinoma
De-jun SHU1, Yu-guang SHEN1 , Ji-yang TANG1, Wei-fu ZHOU1, Xun LU1, Yong MEI2
Affiliations
  • 1.Department of Thoracic Surgery, First People’s Hospital of Zunyi City/Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
  • 2.Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China
出版时间: 2025-09-28 doi: 10.13699/j.cnki.1001-6821.2025.18.006
文章导航
收藏切换
摘要
收起
目的

观察埃克替尼片治疗纵隔复发性鳞状细胞癌的临床疗效和安全性。

方法

将纵隔复发性鳞状细胞癌患者按随机数表法分为对照组和试验组。对照组给予多西他赛注射液75 mg·m-2静脉滴注，每3周1次，共4个疗程；试验组给予埃克替尼片150 mg，口服，每日3次，连续用药12周。比较2组患者的临床疗效、疾病控制率、无进展生存期、生活质量评分和生理学实验室指标，并进行安全性评价。

结果

共纳入105例受试者，试验过程中共脱落3例，最终试验组和对照组分别纳入52例和50例。治疗后，试验组和对照组的总有效率（ORR）分别为42.31%（22例/52例）和32.00%（16例/50例）；疾病控制率（DCR）分别为76.92%（40例/52例）和60.00%（30例/50例）；中位无进展生存期（PFS）分别为5.60个月和4.20个月；中位总生存期（OS）分别为16.90个月和10.50个月；总体健康状况评分分别为（72.61±13.96）和（63.62±16.94）分；功能量表评分分别为（80.19±15.73）和（68.39±14.55）分；症状量表评分分别为（31.41±12.61）和（41.81±10.57）分；白细胞计数（WBC）分别为（2.31±1.50）和（4.45±1.00）×109·L-1；中性粒细胞计数（NEU）分别为（3.70±1.38）和（1.96±0.95）×109·L-1；血红蛋白（Hb）分别为（119.39±17.40）和（109.98±14.04）g·L-1；血小板计数（PLT）分别为（217.68±50.33）和（164.93±56.01）×109·L-1，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（均P<0.05）。试验组的药物不良反应主要有皮疹、腹泻和转氨酶升高，对照组的药物不良反应主要有骨髓抑制、脱发和恶心呕吐。试验组和对照组的总药物不良反应发生率分别为82.69%和90.00%，在统计学上差异无统计学意义（P>0.05），但试验组3 ~ 4级药物不良反应发生率显著低于对照组（11.54% vs. 30.00%，P<0.05）。

结论

与多西他赛注射液比较，埃克替尼片治疗纵隔复发性鳞状细胞癌的疗效更佳，且对血液系统毒性更小，重度药物不良反应发生率更低，安全性更好。

埃克替尼片  /  多西他赛注射液  /  纵隔复发性鳞状细胞癌  /  临床疗效  /  药物不良反应
Objective

To observe the clinical efficacy and safety of icotinib in the treatment of patients with recurrent mediastinal squamous cell carcinoma.

Methods

Patients with recurrent mediastinal squamous cell carcinoma were randomly divided into control group and treatment group using a random number table. Control group received docetaxel injection 75 mg·m-2, intravenous infusion, once every 3 weeks for 4 cycles; treatment group received icotinib 150 mg, orally, 3 times daily for 12 consecutive weeks. The clinical efficacy, disease control rate, progression-free survival, quality of life scores, physiological laboratory indicators and the incidence of adverse drug reactions were compared between the two groups.

Results

A total of 105 patients were enrolled, 3 cases were excluded during the trial, leaving 52 participants in treatment group and 50 in control group. After treatment, the objective response rates (ORR) for treatment group and control group were 42.31% (22 cases /52 cases) and 32.00% (16 cases /50 cases); the disease control rates (DCR) were 76.92% (40 cases/52 cases) and 60.00% (30 cases/50 cases); the median progression-free survival (PFS) were 5.60 and 4.20 months; the median overall survival (OS) were 16.90 and 10.50 months; the overall health status were (72.61±13.96) and (63.62±16.94) points, respectively; the functional scale scores were (80.19±15.73) and (68.39±14.55) points, respectively; the symptom scale scores were (31.41±12.61) and (41.81±10.57) points, respectively; white blood cell count (WBC) were (2.31±1.50) and (4.45±1.00)×109 cell·L-1 ; neutrophil count (NEU) were (3.70±1.38) and (1.96±0.95)×109 cell·L-1; hemoglobin (Hb) were (119.39±17.40) and (109.98±14.04) g·L-1; platelet count (PLT) were (217.68±50.33) and (164.93±56.01)×109 cell·L-1. Compared with control group, the above indexes in treatment group all had significant differences (all P<0.05). The main adverse drug reactions in treatment group were rash, diarrhea and elevated transaminase; in control group were bone marrow suppression, alopecia, nausea and vomiting . There was no significant difference in the total incidence of adverse drug reactions between the two groups (82.69% vs. 90.00%, P>0.05). However, the incidence of grade 3-4 adverse drug reactions in treatment group was significantly lower than that in control group (11.54% vs. 30.00%, P<0.05).

Conclusion

Icotinib tablet is more effective than docetaxel injection in treating recurrent mediastinal squamous cell carcinoma, with less hematological toxicity, lower incidence of severe adverse reactions, and better safety profile.

icotinib tablet  /  docetaxel injection  /  recurrent mediastinal squamous cell carcinoma  /  clinical efficacy  /  adverse reactions
舒德军, 沈玉光, 唐激扬, 周维富, 卢勋, 梅永. 埃克替尼治疗纵隔复发性鳞状细胞癌患者的临床研究. 中国临床药理学杂志, 2025 , 41 (18) : 2605 -2610 . DOI: 10.13699/j.cnki.1001-6821.2025.18.006
De-jun SHU, Yu-guang SHEN, Ji-yang TANG, Wei-fu ZHOU, Xun LU, Yong MEI. Clinical study of icotinib in the treatment of patients with recurrent mediastinal squamous cell carcinoma[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (18) : 2605 -2610 . DOI: 10.13699/j.cnki.1001-6821.2025.18.006
基金
收起
  • 贵州省科技计划基金资助项目(黔科合基础-[2024]青年268号)
  • 贵州省遵义市科技局科技计划基金资助项目(遵市科合HZ字（2021）272号)
文献
收起
参考文献 引证文献
排序方式：
2025年第41卷第18期
PDF下载
149
26
引用本文
BibTeX
文章信息
doi: 10.13699/j.cnki.1001-6821.2025.18.006
  • 接收时间：2025-04-28
  • 首发时间：2026-08-05
  • 出版时间：2025-09-28
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期：2025-04-28
基金
贵州省科技计划基金资助项目(黔科合基础-[2024]青年268号)
贵州省遵义市科技局科技计划基金资助项目(遵市科合HZ字（2021）272号)
作者信息
    1.遵义市第一人民医院/遵义医科大学 第三附属医院 胸外科，贵州 遵义 563000
    2.贵州医科大学 附属医院 肝胆外科，贵州 贵阳 550001

通讯作者:

沈玉光，主任医师，硕士生导师 MP: 13595259966 E-mail:
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.18.006
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62199257（仅加盟咨询）
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持