Article(id=1291704812043784549, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.18.004, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1749398400000, receivedDateStr=2025-06-09, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896025905, onlineDateStr=2026-08-05, pubDate=1758988800000, pubDateStr=2025-09-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896025905, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896025905, creator=13701087609, updateTime=1785896025905, updator=13701087609, issue=Issue{id=1291704811443999077, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='18', pageStart='2551', pageEnd='2700', issueExtLink='null', onlineDate='null', pubDate='1758988800000', pubDateStr='2025-09-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896025763, creator='13701087609', updateTime=1785896871490, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708358743053253, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708358743053254, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2594, endPage=2598, ext={EN=ArticleExt(id=1291704812282859878, articleId=1291704812043784549, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical research on the effect of dapagliflozin combined with semaglutide in the treatment of patients with type 2 diabetes mellitus complicated with abdominal obesity, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the clinical effect of dapagliflozin tables combined with semaglutide injection in the treatment of patients with type 2 diabetes mellitus (T2DM) accompanied by abdominal obesity.
Methods Patients with T2DM accompanied by abdominal obesity were divided into the control group and the treatment group by the random number table method. The control group took dapagliflozin tables orally once a day, 10 mg each time. The treatment group was hypodermic injection with semaglutide injection once a week on the basis of the control group, 0.5 mg each time. Both groups were treated for 3 months. The lipid metabolism, glucose metabolism, body mass index (BMI), waist circumference(WC), serological indicators, adipokines and adverse drug reactions were compared between the 2 groups.
Results In this study, 84 cases were enrolled in the treatment group and 83 cases in the control group, and 3 cases fell off in both groups. Finally, 81 cases were enrolled in the treatment group and 80 cases in the control group. After treatment, the low-density lipoprotein cholesterol (LDL-C) in the treatment group and the control group were (3.21±0.43) and (3.57±0.54) mmol·L-1, respectively, and the glycated hemoglobin (HbAlc) were (5.42±0.67)% and (6.95±0.75)%, respectively; the homeostasis model assessment of insulin resistance (HOMA-IR) were (2.02±0.37) and (2.45±0.48) respectively, the BMI were (26.02±2.11) and (27.12±2.38) kg·m-2, respectively, and the WC were (90.25±8.17) and (95.07±9.14) cm, respectively; insulin-like growth factor (IGF) were (154.31±15.68) and (165.23±17.08) mmol·L-1, respectively, and asprosin (ASP) were (1.20±0.31) and (1.37±0.38) μg·L-1, respectively; the spexin (SPX) were (0.78±0.19) and (0.65±0.14) ng·mL-1, respectively, while the difference of above indexes in treatment and control groups were all statistically significant (all P<0.05). The adverse drug reaction incidence in treatment and control groups were 8.64% and 5.00%, respectively, showing no statistically significant difference (P>0.05).
Conclusion Dapagliflozin tables combined with semaglutide injection can effectively regulate the glycolipid metabolism of patients with type 2 diabetes mellitus (T2DM) accompanied by abdominal obesity, reduce BMI and WC, regulate adipokines, inhibit the expression of serum IGF, and with reliable safety.
, authors=Chun-yan LU, Jing FENG, Wei-wei WANG, authorsList=Chun-yan LU, Jing FENG, Wei-wei WANG, authorCompany=null, correspAuthors=Chun-yan LU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704812689707367, articleId=1291704812043784549, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=达格列净联合司美格鲁肽治疗2型糖尿病伴腹型肥胖患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 分析2型糖尿病（T2DM）伴腹型肥胖患者用达格列净片与联合司美格鲁肽注射液治疗的临床疗效和安全性。
方法 将T2DM伴腹型肥胖患者用随机数表法分为对照组和试验组。对照组每天口服1次达格列净，每次10 mg。试验组在对照组的基础上每周皮下注射1次司美格鲁肽，每次0.5 mg。2组均治疗3个月。对比2组的脂代谢、糖代谢、体质量指数（BMI）、腰围（WC）、血清学指标、脂肪因子及血清学指标，并进行安全性评价。
结果 本研究试验组和对照组分别入组84例及83例，2组均脱落3例，最终试验组、对照组分别纳入81例及80例进行统计分析。治疗后，试验组和对照组低密度脂蛋白胆固醇（LDL-C）分别为（3.21±0.43）和（3.57±0.54）mmol·L-1，糖化血红蛋白（HbAlc）分别为（5.42±0.67）%和（6.95±0.75）%，胰岛素抵抗指数（HOMA-IR）分别为2.02±0.37和2.45±0.48，BMI分别为（26.02±2.11）和（27.12±2.38）kg·m-2，WC分别为（90.25±8.17）和（95.07±9.14）cm，胰岛素样生长因子（IGF）分别为（154.31±15.68）和（165.23±17.08）mmol·L-1，白脂素（ASP）分别为（1.20±0.31）和（1.37±0.38）μg·L-1，神经肽（SPX）分别为（0.78±0.19）和（0.65±0.14）ng·mL-1，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（均P<0.05）。2组总药物不良反应发生率分别为8.64%和5.00%，在统计学上差异无统计学意义（P>0.05）。
结论 达格列净片联合司美格鲁肽注射液可有效调节T2DM伴腹型肥胖患者糖脂代谢，可降低BMI与WC，调节脂肪因子，抑制血清IGF表达，且安全性可靠。
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卢春燕（1982-），女，副主任医师，主要从事内分泌疾病临床工作和研究
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