Article(id=1291704943862375243, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.17.020, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1744732800000, receivedDateStr=2025-04-16, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896057330, onlineDateStr=2026-08-05, pubDate=1758038400000, pubDateStr=2025-09-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896057330, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896057330, creator=13701087609, updateTime=1785896057330, updator=13701087609, issue=Issue{id=1291704771212234905, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='17', pageStart='2401', pageEnd='2550', issueExtLink='null', onlineDate='null', pubDate='1758038400000', pubDateStr='2025-09-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896016147, creator='13701087609', updateTime=1785896900366, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708479866164175, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708479866164176, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2516, endPage=2520, ext={EN=ArticleExt(id=1291704944118227789, articleId=1291704943862375243, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Pharmaceutical care of patients with severe type Ⅱ thrombocytopenia induced by low molecular weight heparin complicated by thrombus, columnId=1291704944038536012, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Rational Use of Drugs, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the anticoagulant treatment of patients with low molecular weight heparin-induced severe type II thrombocytopenia complicated by multi-site embolism, and to provide reference for rational use of anticoagulant drugs in clinic.
Methods Clinical pharmacists participated in the diagnosis and treatment of a patient with heparin-induced thrombocytopenia(HIT) with multiple thrombus. According to the patient’s pathophysiology, auxiliary examination and other conditions, combined with literature review and individualized medication monitoring, they assisted in formulating and optimizing the anticoagulant treatment plan, improving the quality of pharmaceutical care, and promoting clinical rational drug use.
Results The clinical pharmacist assisted in identifying the cause of thrombocytopenia, with a 4T’s HIT score of 7 (indicating high probability of HIT) and positive HIT antibody(HIT-Ab) (6.2 U·mL-1). Following argatroban anticoagulation therapy, the patient’s blood platelet count (PLT) improved from 11 to 87 ×10 ·L-1, while D-dimer levels peaked at 60.08 mg·L-1 FEU before declining to 30.60 mg·L-1 FEU. Activated partial thromboplastin time (APTT) remained stable at approximately 50 seconds. No new thrombotic or hemorrhagic events occurred, and the clinical outcome was favorable.
Conclusion Although low molecular weight heparin-induced thrombocytopenia is rare, it still needs clinical attention. Clinical pharmacists can assist physicians in formulating individualized treatment plans for patients from the perspective of pharmaceutical professionals to ensure the rationality of clinical drug use.
, authors=Xiao-wan TANG
1a, Hui-xin ZHAO
2, Xi-tao SONG
1b, Dan ZHANG
1a, 3, Li-ping DU
1a, authorsList=Xiao-wan TANG, Hui-xin ZHAO, Xi-tao SONG, Dan ZHANG, Li-ping DU, authorCompany=null, correspAuthors=Li-ping DU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704944529269583, articleId=1291704943862375243, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=低分子肝素致重度Ⅱ型血小板减少症并发血栓患者的药学监护, columnId=1291704944210502478, journalTitle=中国临床药理学杂志, columnName=合理用药, runingTitle=null, highlight=null, articleAbstract=
目的 分析探讨临床药师参与低分子肝素诱导重度Ⅱ型血小板减少症并发多部位栓塞患者的抗凝治疗过程，为临床合理使用抗凝药物提供参考。
方法 临床药师参与1例肝素诱导血小板减少症（HIT）伴多发血栓患者的诊疗，根据患者病生理、辅助检查等情况，结合文献及个体化用药监护，协助制定、优化抗凝治疗方案，提升药学监护质量，促进临床合理用药。
结果 临床药师协助明确血小板减少原因，4T’s评分7分（高度怀疑HIT），HIT-抗体（HIT-Ab）阳性（6.2 U·mL-1）。经阿加曲班治疗后，患者血小板计数（PLT）从11 ×109·L-1升至87 ×109·L-1，D-二聚体（D-dimer）由峰值60.08 mg·L-1 FEU降至30.60 mg·L-1 FEU，活化部分凝血活酶时间（APTT）稳定于50 s左右，未出现新发血栓或出血，预后良好。
结论 低分子肝素诱导的血小板减少症虽罕见但仍需引起临床高度重视，临床药师可从药学专业角度协助医师为患者制定个体化治疗方案，保障临床用药合理性。
, authors=唐筱婉
1a, 赵会新
2, 宋希涛
1b, 张丹
1a, 3, 都丽萍
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唐筱婉（1989-），主管药师，主要从事医院药学、临床药学方面的临床工作和研究
赵会新（1987-），主管药师，主要从事医院药学、临床药学方面的临床工作和研究
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赵会新（1987-），主管药师，主要从事医院药学、临床药学方面的临床工作和研究
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1b.Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704946991326058, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704943862375243, authorId=1291704946836136807, language=CN, stringName=宋希涛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1b.中国医学科学院 北京协和医院 血管外科，北京 100730, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704945263272787, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704943862375243, xref=1b., ext=[AuthorCompanyExt(id=1291704945271661396, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704943862375243, companyId=1291704945263272787, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1a.Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
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1a.中国医学科学院 北京协和医院 药剂科，北京 100730
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