Article(id=1291704990754693238, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.17.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1753200000000, receivedDateStr=2025-07-23, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896068513, onlineDateStr=2026-08-05, pubDate=1758038400000, pubDateStr=2025-09-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896068513, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896068513, creator=13701087609, updateTime=1785896068513, updator=13701087609, issue=Issue{id=1291704771212234905, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='17', pageStart='2401', pageEnd='2550', issueExtLink='null', onlineDate='null', pubDate='1758038400000', pubDateStr='2025-09-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896016147, creator='13701087609', updateTime=1785896900366, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708479866164175, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708479866164176, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2441, endPage=2445, ext={EN=ArticleExt(id=1291704990951825527, articleId=1291704990754693238, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of evidence-based investigation on off-label use of escitalopram in children and adolescents, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the off-label drug use of escitalopram in children and adolescents, and to provide a reference for rational clinical medication.
Methods Collected prescription data of children and adolescents (<18 years) receiving antidepressant treatment, including gender, age, clinical diagnosis, drug name, dosage, frequency and route of administration. Based on domestic drug labeling, we assessed whether escitalopram was used off-label, and further conducted evidence-based searches regarding its off-label drug use. A literature search was conducted using the keywords escitalopram, off-label use, evidence-based medicine, children and adolescents across multiple electronic databases, including PubMed, Embase, The Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang and VIP.
Results This study included a total of 156 504 outpatients, with escitalopram prescribed to 9 798, the off-label use rate was 6.26%. An analysis of the off-label use of escitalopram was conducted based on 22 articles, including the original drug instructions, evidence-based databases and related medical literature, the results demonstrated that escitalopram was supported by evidence for the use of both depression and generalized anxiety disorder in children and adolescents.
Conclusion Escitalopram has preliminary evidence-based support for its use in children and adolescent patients, it is an off-label application. Therefore, clinical practice should strengthen the supervision and management of off-label use of escitalopram to ensure medication safety for patients.
, authors=Shuang BAO
1, 2, Shan-shan LIU
1, 2, Yan-nan ZANG
1, 2, Fei JIA
1, 2, Xiao-qian LAN
1, 2, Hong-yan ZHUANG
1, 2, Meng-xi NIU
1, 2, Peng-fei LI
1, 2, authorsList=Shuang BAO, Shan-shan LIU, Yan-nan ZANG, Fei JIA, Xiao-qian LAN, Hong-yan ZHUANG, Meng-xi NIU, Peng-fei LI, authorCompany=null, correspAuthors=Peng-fei LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704991308341368, articleId=1291704990754693238, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于循证医学证据的儿童青少年艾司西酞普兰超说明书用药情况研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 调查艾司西酞普兰在儿童青少年人群中的超说明书使用情况，为临床合理用药提供参考。
方法 以本院门诊接受抗抑郁药物治疗的儿童青少年（<18岁）患儿纳入为研究对象，收集患者的性别、年龄、临床诊断、药品名称、给药剂量、给药频率和给药途径等病例信息。依据国内药品说明书判断艾司西酞普兰是否存在超说明书用药的情况，并对其超说明书用药情况以艾司西酞普兰、超说明书用药、循证医学、儿童和青少年为关键词在PubMed、Embase、The Cochrane Library、Web of Science、中国知网（CNKI）、万方和维普（VIP）数据库进行循证证据检索。
结果 共纳入门诊患者156 502人次，其中，使用艾司西酞普兰的患者为9 798人次，超说明书用药率为6.26%。艾司西酞普兰超说明书用药循证医学证据检索共纳入22篇文献，涵盖原研药品说明书、循证数据库以及相关医学文献，结果表明，艾司西酞普兰用于儿童青少年抑郁症和广泛性焦虑障碍具有循证证据支持。
结论 艾司西酞普兰用于儿童青少年患者具备初步的循证依据，但仍属于超说明书用药范畴。因此，临床实践中应加强对艾司西酞普兰的监督和管理，保障患者用药安全。
, authors=鲍爽
1, 2, 刘珊珊
1, 2, 臧彦楠
1, 2, 贾菲
1, 2, 兰晓倩
1, 2, 庄红艳
1, 2, 牛梦溪
1, 2, 李鹏飞
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鲍爽（1987-），女，副主任药师，主要从事精神科合理用药方面的临床工作和研究
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1.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development/Beijing Key Laboratory of Mental Disorders/National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
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1.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development/Beijing Key Laboratory of Mental Disorders/National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
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1.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development/Beijing Key Laboratory of Mental Disorders/National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
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1.首都医科大学 附属北京安定医院 国家精神疾病医学中心/国家精神心理疾病临床医学研究中心/精神疾病诊断与治疗北京市重点实验室/慢病新药创制关键桥接技术北京市重点实验室，北京 100088
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1, 2, address=
1.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development/Beijing Key Laboratory of Mental Disorders/National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
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1, 2, address=
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