Article(id=1291404847903928635, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404791758975909, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.11.023, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1731340800000, receivedDateStr=2024-11-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824508881, onlineDateStr=2026-08-04, pubDate=1750089600000, pubDateStr=2025-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824508881, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824508881, creator=13701087609, updateTime=1785824508881, updator=13701087609, issue=Issue{id=1291404791758975909, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1750089600000', pubDateStr='2025-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824495496, creator='13701087609', updateTime=1785824495496, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1628, endPage=1633, ext={EN=ArticleExt(id=1291404848235278652, articleId=1291404847903928635, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of Chinese medicinal monomers and formulas in the intervention of postmenopausal osteoporosis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Postmenopausal osteoporosis (PMOP) is a systemic metabolic bone disease characterised by significant bone loss and deterioration of the bone microstructure. Although traditional anti-osteoporosis drugs have been shown to be effective in preventing and treating PMOP, they can also cause various side effects. Traditional Chinese medicine has been used to treat various diseases for many years and is widely used to treat PMOP due to its high tolerability, low toxicity, good efficacy and minimal adverse reactions. This review summarises the mechanisms of action of PMOP and the current state of research on the mechanisms of action of commonly used Chinese medicinal compounds and combinations for treating PMOP. The aim is to provide ideas for the future clinical treatment of PMOP and related basic research.

, authors=Dong LIU1, Ping-an CHU1, Ning LI1, 2, Xing-wen XIE1, 2, Yuan CHEN1, De-min LIN1, Jiang-feng HAO1, authorsList=Dong LIU, Ping-an CHU, Ning LI, Xing-wen XIE, Yuan CHEN, De-min LIN, Jiang-feng HAO, authorCompany=null, correspAuthors=Ning LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404848625348925, articleId=1291404847903928635, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中药单体及复方干预绝经后骨质疏松症的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

绝经后骨质疏松症(PMOP)是一种全身代谢性骨骼疾病,以大量骨丢失和骨微结构恶化为特征。传统的抗骨质疏松药物在预防和治疗PMOP方面具有较好的效果,但在发挥疗效的过程中也会出现各种各样的药物不良反应。中医药用于多种疾病的治疗已经有多年的历史,以其耐受性好、毒性较低、疗效好、药物不良反应较小等优点被广泛应用于PMOP的治疗中。本文归纳了PMOP的作用机制及综述了常用的中药单体和中药复方治疗PMOP作用机制的研究现况,以期为今后PMOP的临床治疗和相关基础研究提供思路。

, authors=刘东1, 褚平铵1, 李宁1, 2, 谢兴文1, 2, 程渊1, 林德民1, 郝江峰1, authorsList=刘东, 褚平铵, 李宁, 谢兴文, 程渊, 林德民, 郝江峰, authorCompany=null, correspAuthors=李宁, authorNote=

刘东(1995-),男,博士研究生,主要从事中医药治疗骨与关节疾病的相关研究

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李宁,教授,博士生导师 MP: 17760579068 E-mail:
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刘东(1995-),男,博士研究生,主要从事中医药治疗骨与关节疾病的相关研究

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中药单体及复方干预绝经后骨质疏松症的研究现状
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刘东 1 , 褚平铵 1 , 李宁 1, 2 , 谢兴文 1, 2 , 程渊 1 , 林德民 1 , 郝江峰 1
中国临床药理学杂志 | 综述 2025,41(11): 1628-1633
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中国临床药理学杂志 |综述 2025 , 41 (11) : 1628 -1633
中药单体及复方干预绝经后骨质疏松症的研究现状
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刘东(1995-),男,博士研究生,主要从事中医药治疗骨与关节疾病的相关研究

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刘东(1995-),男,博士研究生,主要从事中医药治疗骨与关节疾病的相关研究

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刘东1, 褚平铵1, 李宁1, 2 , 谢兴文1, 2, 程渊1, 林德民1, 郝江峰1
作者信息
  • 1.甘肃中医药大学 中医临床学院,甘肃 兰州 730000
  • 2.甘肃中医药大学 附属医院 康复骨科,甘肃 兰州 730000
通讯作者:
李宁,教授,博士生导师 MP: 17760579068 E-mail:
作者简介:

刘东(1995-),男,博士研究生,主要从事中医药治疗骨与关节疾病的相关研究

Research status of Chinese medicinal monomers and formulas in the intervention of postmenopausal osteoporosis
Dong LIU1, Ping-an CHU1, Ning LI1, 2 , Xing-wen XIE1, 2, Yuan CHEN1, De-min LIN1, Jiang-feng HAO1
Affiliations
  • 1.Clinical School of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 2.Department of Rehabilitation Orthopedics, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
出版时间: 2025-06-17 doi: 10.13699/j.cnki.1001-6821.2025.11.023
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绝经后骨质疏松症(PMOP)是一种全身代谢性骨骼疾病,以大量骨丢失和骨微结构恶化为特征。传统的抗骨质疏松药物在预防和治疗PMOP方面具有较好的效果,但在发挥疗效的过程中也会出现各种各样的药物不良反应。中医药用于多种疾病的治疗已经有多年的历史,以其耐受性好、毒性较低、疗效好、药物不良反应较小等优点被广泛应用于PMOP的治疗中。本文归纳了PMOP的作用机制及综述了常用的中药单体和中药复方治疗PMOP作用机制的研究现况,以期为今后PMOP的临床治疗和相关基础研究提供思路。

中医药  /  中药单体  /  活性成分  /  绝经后骨质疏松

Postmenopausal osteoporosis (PMOP) is a systemic metabolic bone disease characterised by significant bone loss and deterioration of the bone microstructure. Although traditional anti-osteoporosis drugs have been shown to be effective in preventing and treating PMOP, they can also cause various side effects. Traditional Chinese medicine has been used to treat various diseases for many years and is widely used to treat PMOP due to its high tolerability, low toxicity, good efficacy and minimal adverse reactions. This review summarises the mechanisms of action of PMOP and the current state of research on the mechanisms of action of commonly used Chinese medicinal compounds and combinations for treating PMOP. The aim is to provide ideas for the future clinical treatment of PMOP and related basic research.

traditional Chinese medicine  /  monomer of traditional Chinese medicine  /  active ingredients  /  postmenopausal osteoporosis
刘东, 褚平铵, 李宁, 谢兴文, 程渊, 林德民, 郝江峰. 中药单体及复方干预绝经后骨质疏松症的研究现状. 中国临床药理学杂志, 2025 , 41 (11) : 1628 -1633 . DOI: 10.13699/j.cnki.1001-6821.2025.11.023
Dong LIU, Ping-an CHU, Ning LI, Xing-wen XIE, Yuan CHEN, De-min LIN, Jiang-feng HAO. Research status of Chinese medicinal monomers and formulas in the intervention of postmenopausal osteoporosis[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (11) : 1628 -1633 . DOI: 10.13699/j.cnki.1001-6821.2025.11.023
  • 国家自然科学基金面上项目基金资助项目(82374491; 82174412)
  • 中央高校基本科研业务费基金资助项目(31920210041)
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2025年第41卷第11期
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doi: 10.13699/j.cnki.1001-6821.2025.11.023
  • 接收时间:2024-11-12
  • 首发时间:2026-08-04
  • 出版时间:2025-06-17
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  • 收稿日期:2024-11-12
基金
国家自然科学基金面上项目基金资助项目(82374491; 82174412)
中央高校基本科研业务费基金资助项目(31920210041)
作者信息
    1.甘肃中医药大学 中医临床学院,甘肃 兰州 730000
    2.甘肃中医药大学 附属医院 康复骨科,甘肃 兰州 730000

通讯作者:

李宁,教授,博士生导师 MP: 17760579068 E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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