Article(id=1291404828224250805, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404791758975909, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.11.020, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1735228800000, receivedDateStr=2024-12-27, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824504189, onlineDateStr=2026-08-04, pubDate=1750089600000, pubDateStr=2025-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824504189, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824504189, creator=13701087609, updateTime=1785824504189, updator=13701087609, issue=Issue{id=1291404791758975909, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1750089600000', pubDateStr='2025-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824495496, creator='13701087609', updateTime=1785824495496, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1614, endPage=1618, ext={EN=ArticleExt(id=1291404828442354614, articleId=1291404828224250805, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status on the effects and mechanism of phosphatidylethanolamine in atherosclerosis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Atherosclerosis (AS), a multifactorial inflammatory disease characterized by complex interactions among biomolecules and signaling pathways, poses significant cardiovascular risks. Emerging evidence highlights phosphatidylethanolamine (PE), a key phospholipid component of cellular membranes, as playing pivotal regulatory roles in both the initiation and progression of AS. While existing studies have elucidated PE’s fundamental biological functions, its precise molecular mechanisms governing inflammatory responses, lipid homeostasis, and signal transduction remain incompletely characterized. This comprehensive review systematically examines PE’s involvement in atherogenesis, explores its underlying pathophysiological mechanisms, and critically evaluates current research limitations alongside promising therapeutic avenues. Through this synthesis, we aim to advance mechanistic understanding of PE’s pleiotropic functions and inform novel intervention strategies for atherosclerotic cardiovascular diseases.

, authors=Yuan-hong LIAO^1a, Jing-kun LU^1b, Jun LI^{1a, 1c}, Xin TAN^1b, Qiang WEI^1b, Cheng-dong LIU^1a, Ren BU^1a, Yue-wu WANG^{1a, 1c}, authorsList=Yuan-hong LIAO, Jing-kun LU, Jun LI, Xin TAN, Qiang WEI, Cheng-dong LIU, Ren BU, Yue-wu WANG, authorCompany=null, correspAuthors=Yue-wu WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404828744344503, articleId=1291404828224250805, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=磷脂酰乙醇胺在动脉粥样硬化中的作用及其机制的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

动脉粥样硬化（AS）是一种复杂且多因素的心血管疾病，其发病机制涉及多种生物分子和信号通路的相互作用。磷脂酰乙醇胺（PE）作为细胞膜的重要组成部分，对AS的发生和发展具有重要影响。尽管已有研究探讨了PE在细胞生物学中的作用，但其在炎症反应、脂质代谢和细胞信号转导中的具体机制尚未被充分阐明。本文综述PE在AS中的作用，分析其潜在机制，并探讨研究现状及未来方向，为理解PE的生物学功能提供新视角。

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廖园红（1997-），男，硕士研究生，主要从事心血管药理及微生物与生化药学研究

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廖园红（1997-），男，硕士研究生，主要从事心血管药理及微生物与生化药学研究

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