Article(id=1291404922176656296, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404791758975909, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.11.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1735056000000, receivedDateStr=2024-12-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824526589, onlineDateStr=2026-08-04, pubDate=1750089600000, pubDateStr=2025-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824526589, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824526589, creator=13701087609, updateTime=1785824526589, updator=13701087609, issue=Issue{id=1291404791758975909, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1750089600000', pubDateStr='2025-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824495496, creator='13701087609', updateTime=1785824495496, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1562, endPage=1568, ext={EN=ArticleExt(id=1291404922415731625, articleId=1291404922176656296, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of Cepharanthine in regulating the progression of breast cancer cells, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effects of Cepharanthine on apoptosis, energy metabolism and angiogenesis of breast cancer cells by regulating the microRNA (miR)-378c/Golgi transport 1A protein (GOLT1A) axis.
Methods MDA-MB-231 cells in the logarithmic growth phase were divided into the following groups: Control group (no treatment), NC inhibitor group (transfected with miR-378c inhibitor negative control), miR-378c inhibitor group (transfected with miR-378c inhibitor), si-NC group (transfected with si-NC plasmid), si-GOLT1A group (transfected with si-GOLT1A plasmid), Cepharanthine group (20 μmol·L-1 Cepharanthine), Cepharanthine combined with miR-378c inhibitor group (Cepharanthine group with miR-378c inhibitor transfection) and miR-378c inhibitor combined with si-GOLT1A group (Cepharanthine group with co-transfection of miR-378c inhibitor and si-GOLT1A plasmid). Real-time fluorescence quantitative polymerase chain reaction was used to detect the relative expression levels of miR-378c, GOLT1A, vascular endothelial growth factor A (VEGFA) and thrombospondin-1 (THBS1); kits were used to detect energy metabolism indicators; immunofluorescence was used to detect VEGFA and THBS1 expression levels.
Results The relative expression levels of miR-378c in the control group and Cepharanthine group were 1.00±0.14 and 3.26±0.48, respectively; the relative expression levels of GOLT1A mRNA were 1.00±0.15 and 0.43±0.07, respectively. The glutamine concentrations in the control group, Cepharanthine group, Cepharanthine combined with miR-378c inhibitor group and miR-378c inhibitor combined with si-GOLT1A group were (22.03±3.14), (8.27±1.94), (17.25±2.86) and (13.11±2.28) nmol·10-7 cells, respectively; the acetyl coenzyme A concentrations were (11.32±2.06), (5.71±1.19), (9.62±1.85) and (6.67±1.63) nmol·10-6 cells, respectively; the succinate concentrations were (53.67±6.92), (21.24±3.87), (39.82±4.39) and (30.36±4.21) nmol·mg-1·Pr-1, respectively; the ATP production values were (2.32±0.42), (0.96±0.12), (1.91±0.33) and (1.16±0.26) mmol·mg-1·Pr-1, respectively; the relative expression levels of VEGFA mRNA were 1.00±0.14, 0.56±0.10, 0.84±0.13 and 0.69±0.10, respectively; the relative expression levels of THBS1 mRNA were 1.00±0.12, 3.43±0.57, 2.04±0.36 and 3.10±0.52, respectively; the relative fluorescence intensities of VEGFA were 1.00±0.11, 0.37±0.05, 0.76±0.09 and 0.48±0.06, respectively; and the relative fluorescence intensities of THBS1 were 1.00±0.09, 3.71±0.62, 1.88±0.31 and 2.55±0.37, respectively. All the above indicators showed significant differences between the control group and the Cepharanthine group, the Cepharanthine group and the Cepharanthine combined with miR-378c inhibitor group, the Cepharanthine combined with miR-378c inhibitor group and the miR-378c inhibitor combined with si-GOLT1A group (P<0.05, P<0.01, P<0.001).
Conclusion Cepharanthine can promote apoptosis and inhibit energy metabolism and angiogenesis in breast cancer cells, which may be related to its regulation of the miR-378c/GOLT1A axis.
, authors=Jun-jie JIANG, Wei ZHANG, Chun-jia CHANG, Chun-hui JI, Ran ZHANG, authorsList=Jun-jie JIANG, Wei ZHANG, Chun-jia CHANG, Chun-hui JI, Ran ZHANG, authorCompany=null, correspAuthors=Wei ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404922789024682, articleId=1291404922176656296, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=千金藤素调控乳腺癌细胞进展的作用, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 研究千金藤素通过调控微小RNA-378c（miR-378c）/高尔基体运输1A蛋白（GOLT1A）轴对乳腺癌细胞凋亡、能量代谢及血管生成的影响。
方法 将处于对数生长期MDA-MB-231细胞分为对照组（不做任何处理）、NC inhibitor组（转染miR-378c抑制剂阴性对照）、miR-378c inhibitor组（转染miR-378c抑制剂）、si-NC组（转染si-NC质粒）、si-GOLT1A组（转染si-GOLT1A质粒）、千金藤素组（20 μmol·L-1的千金藤素）、千金藤素联合miR-378c inhibitor组（千金藤素组基础上转染miR-378c抑制剂）和miR-378c inhibitor联合si-GOLT1A组（千金藤素组基础上共转染miR-378c抑制剂和si-GOLT1A质粒）。用实时荧光定量聚合酶链反应检测miR-378c、GOLT1A、血管内皮生长因子A（VEGFA）、血小板反应蛋白-1（THBS1）的mRNA相对表达水平，用试剂盒法检测能量代谢指标，用免疫荧光法检测VEGFA、THBS1蛋白相对表达水平。
结果 对照组和千金藤素组的miR-378c相对表达水平分别为1.00±0.14和3.26±0.48，GOLT1A mRNA相对表达水平分别为1.00±0.15和0.43±0.07。对照组、千金藤素组、千金藤素联合miR-378c inhibitor组和miR-378c inhibitor联合si-GOLT1A组的谷氨酰胺浓度分别为（22.03±3.14）、（8.27±1.94）、（17.25±2.86）和（13.11±2.28） nmol·10-7 cells，乙酰辅酶A浓度分别为（11.32±2.06）、（5.71±1.19）、（9.62±1.85）和（6.67±1.63） nmol·10-6 cells，琥珀酸浓度分别为（53.67±6.92）、（21.24±3.87）、（39.82±4.39）和（30.36±4.21） nmol·mg-1·Pr-1，腺苷三磷酸生成量分别为（2.32±0.42）、（0.96±0.12）、（1.91±0.33）和（1.16±0.26） mmol·mg-1·Pr-1，VEGFA mRNA相对表达水平分别为1.00±0.14、0.56±0.10、0.84±0.13和0.69±0.10，THBS1 mRNA相对表达水平分别为1.00±0.12、3.43±0.57、2.04±0.36和3.10±0.52，VEGFA相对荧光强度分别为1.00±0.11、0.37±0.05、0.76±0.09和0.48±0.06，THBS1相对荧光强度分别为1.00±0.09、3.71±0.62、1.88±0.31和2.55±0.37；对照组的上述指标与千金藤素组比较，千金藤素组的上述指标与千金藤素联合miR-378c inhibitor组比较，千金藤素联合miR-378c inhibitor组的上述指标与miR-378c inhibitor联合si-GOLT1A组比较，在统计学上差异均有统计学意义（P<0.05，P<0.01，P<0.001）。
结论 千金藤素能够促进乳腺癌细胞凋亡并抑制其能量代谢及血管生成，可能与其调控miR-378c/GOLT1A轴有关。
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姜俊杰（1982-），女，主治医师，主要从事甲状腺乳腺方面的工作
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