Article(id=1291404801980494830, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404791758975909, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.11.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1734796800000, receivedDateStr=2024-12-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824497932, onlineDateStr=2026-08-04, pubDate=1750089600000, pubDateStr=2025-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824497932, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824497932, creator=13701087609, updateTime=1785824497932, updator=13701087609, issue=Issue{id=1291404791758975909, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1750089600000', pubDateStr='2025-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824495496, creator='13701087609', updateTime=1785824495496, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1550, endPage=1555, ext={EN=ArticleExt(id=1291404802202792943, articleId=1291404801980494830, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research of
LncRNA PCAT19 knockdown on the sensitivity of human gastric cancer cells to oxaliplatin, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the mechanism of long non-coding RNA prostate cancer-associated transcript 19 (LncRNA PCAT19) knockdown on oxaliplatin (OXA) sensitivity of human gastric cancer cells by regulating microRNA (miR)-200c-3p mediated ataxia-telangiectasia mutated proteins (ATM) and Rad3-related kinase-related kinase (ATR) / checkpoint kinase1(CHK1) signaling pathway.
Methods Human gastric adenocarcinoma cells (AGS) were randomly divided into OXA group (8 μg·L-1 OXA), OXA+si-NC+inh-NC group (si-NC and inh-NC co-transfected with +8 μg·L-1 OXA), OXA+si-PCAT19+ inh-NC group (si-PCAT19 and inh-NC co-transfected +8 μg·L-1 OXA), OXA+si-PCAT19+ miR-200c-3p inh group (si-PCAT19 and miR-200c-3p inh co-transfected +8 μg·L-1 OXA). Cell proliferation in each group was detected by 5-acetylidene-2′-deoxyuridine assay; cell apoptosis was detected by in situ terminal transferase labeling technique; cell migration was detected by cell scratch assay; the expression levels of phosphorylated histone H2A.X (γH2A.X) and radiation-sensitive protein 51 (RAD51) were detected by immunofluorescence.
Results In OXA group, OXA+si-NC+inh-NC group, OXA+si-PCAT19+inh-NC group, OXA+si-PCAT19+miR-200c-3p group, the cell proliferation rates were (58.83±6.52)%, (59.42±6.86)%, (45.59±6.09)% and (55.71±7.69)%, respectively; the apoptosis rates were (20.06±2.44)%, (20.32±2.66)%, (31.74±4.43)% and (24.60±3.29)%, respectively; the migration rates were (54.50±6.14)%, (56.11±6.72)%, (31.51±4.13)% and (48.59±7.26)%, respectively; the relative fluorescence intensities of γH2A.X were 1.00±0.08, 0.97±0.12, 4.84±0.82 and 2.11±0.41, respectively; the relative fluorescence intensities of RAD51 were 1.00±0.06, 1.08±0.15, 0.22±0.04 and 0.55±0.08, respectively. There were no significant differences between OXA+si-NC+inh-NC group and OXA group (all P>0.05). The above indexes of OXA+si-PCAT19+inh-NC group were compared with those of OXA+si-NC+inh-NC group, the above indexes in OXA+si-PCAT19+miR-200c-3p inh group were compared with those of OXA+si-PCAT19+inh-NC group, the differences were statistically significant (all P<0.05).
Conclusion Knockdown of LncRNA PCAT19 can affect the proliferation, migration, apoptosis and deoxyribonucleic acid repair of gastric cancer cells by targeting and negatively regulating miR-200c-3p, thereby enhancing the sensitivity of gastric cancer cells to OXA, which may be related to the ATR/CHK1 signaling pathway.
, authors=Li-meng ZUO, Xiao-yu ZHAO, Jian-xin ZHANG, authorsList=Li-meng ZUO, Xiao-yu ZHAO, Jian-xin ZHANG, authorCompany=null, correspAuthors=Jian-xin ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404802479617008, articleId=1291404801980494830, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=敲低
LncRNA PCAT19对人胃癌细胞奥沙利铂敏感性的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究敲低长链非编码核糖核酸前列腺癌相关转录本19（LncRNA PCAT19）通过调控微小核糖核酸（miR）-200c-3p介导共济失调毛细血管扩张突变相关蛋白（ATM）与Rad3相关蛋白激酶（ATR）/细胞周期检查点激酶1（CHK1）信号通路对人胃癌细胞奥沙利铂（OXA）敏感性的机制。
方法 人胃腺癌细胞（AGS）细胞随机分为OXA组（8 μg·L-1 OXA）、OXA+si-NC+inh-NC组（si-NC和inh-NC共转染+8 μg·L-1 OXA）、OXA+si-PCAT19+inh-NC组（si-PCAT19和inh-NC共转染+8 μg·L-1 OXA）、OXA+si-PCAT19+miR-200c-3p inh组（si-PCAT19和miR-200c-3p inh共转染+8 μg·L-1 OXA）。用5-乙炔基-2′-脱氧尿苷实验检测各组细胞增殖情况，用原位末端转移酶标记技术检测各组细胞凋亡情况，用细胞划痕实验检测各组细胞迁移情况，用免疫荧光法检测各组细胞中磷酸化组蛋白H2A.X（γH2A.X）、辐射敏感蛋白51（RAD51）表达水平。
结果 OXA组、OXA+si-NC+inh-NC组、OXA+si-PCAT19+inh-NC组和OXA+si-PCAT19+miR-200c-3p inh组的细胞增殖率分别为（58.83±6.52）%、（59.42±6.86）%、（45.59±6.09）%和（55.71±7.69）%，凋亡率分别为（20.06±2.44）%、（20.32±2.66）%、（31.74±4.43）%和（24.60±3.29）%，迁移率分别为（54.50±6.14）%、（56.11±6.72）%、（31.51±4.13）%和（48.59±7.26）%，γH2A.X相对荧光强度分别为1.00±0.08、0.97±0.12、4.84±0.82和2.11±0.41，RAD51相对荧光强度分别为1.00±0.06、1.08±0.15、0.22±0.04和0.55±0.08，OXA+si-NC+inh-NC组的上述指标与OXA组比较，在统计学上差异均无统计学意义（均P>0.05）；OXA+si-PCAT19+inh-NC组的上述指标与OXA+si-NC+inh-NC组比较、OXA+si-PCAT19+miR-200c-3p inh组的上述指标与OXA+si-PCAT19+inh-NC组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 敲低LncRNA PCAT19通过靶向负调控miR-200c-3p影响胃癌细胞增殖、迁移、凋亡及脱氧核糖核酸修复，从而增强胃癌细胞对OXA的敏感性，这可能与ATR/CHK1信号通路有关。
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左丽萌（1986-），女，讲师，主要从事临床微生物及检验技术等方面的研究
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