Article(id=1291404918649250417, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404875351449891, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.09.024, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1734364800000, receivedDateStr=2024-12-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824525748, onlineDateStr=2026-08-04, pubDate=1747411200000, pubDateStr=2025-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824525748, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824525748, creator=13701087609, updateTime=1785824525748, updator=13701087609, issue=Issue{id=1291404875351449891, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1747411200000', pubDateStr='2025-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824515426, creator='13701087609', updateTime=1785824515426, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1335, endPage=1340, ext={EN=ArticleExt(id=1291404918980600434, articleId=1291404918649250417, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of JNK-mediated signaling network regulation of Alzheimer’s disease, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Neuroinflammation, neuronal damage, and signal fragmentation between neurons make cognitive dysfunction is the main pathological basis of Alzheimer’s disease (AD). It is characterized by significant cognitive and sensory impairment caused by irreversible progressive neurological dysfunction. It is unclear how molecular changes associated with AD affect information processing in neuronal circuits and translate into cognitive dysfunction. c-Jun N-terminal kinase (JNK) plays a key regulatory role in the AD process. In this paper, we review the pathological process of AD research progress of JNK-targeted inhibitory drugs to provide a basis for the treatment of AD diseases and the development and application of targeted drugs.

, authors=Ting CHEN¹, Ping YANG², Xue-mei WANG², Xi-xiang LI², Shuai-yin LI¹, authorsList=Ting CHEN, Ping YANG, Xue-mei WANG, Xi-xiang LI, Shuai-yin LI, authorCompany=null, correspAuthors=Xi-xiang LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404919370670707, articleId=1291404918649250417, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=JNK介导的信号网络调控阿尔茨海默病的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

神经炎症、神经元损伤以及神经元之间信号割裂引发的认知功能障碍是阿尔茨海默病（AD）主要的病理学基础。其特征是明显的认知和感觉障碍，是由不可逆的进行性神经功能障碍引起的。目前尚不清楚与AD相关的分子变化如何影响神经元回路中的信息处理并转化为认知功能障碍。c-Jun氨基末端激酶（JNK）在AD过程中发挥了关键的调控作用。本文就近年来AD病理过程和对JNK靶向抑制药的研究进展进行综述，以期为AD疾病的治疗以及靶向药的开发应用提供依据。

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陈挺（2001-），男，硕士研究生，主要从事中药炮制与制剂工艺的相关研究

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陈挺（2001-），男，硕士研究生，主要从事中药炮制与制剂工艺的相关研究

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