Article(id=1291404934633746523, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404875351449891, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.09.023, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1731168000000, receivedDateStr=2024-11-10, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824529559, onlineDateStr=2026-08-04, pubDate=1747411200000, pubDateStr=2025-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824529559, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824529559, creator=13701087609, updateTime=1785824529559, updator=13701087609, issue=Issue{id=1291404875351449891, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1747411200000', pubDateStr='2025-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824515426, creator='13701087609', updateTime=1785824515426, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1329, endPage=1334, ext={EN=ArticleExt(id=1291404934814101596, articleId=1291404934633746523, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Considerations on the clinical pharmacology of small interfering RNA drugs, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Small interference RNA (siRNA) drugs have unique characteristics in molecular structure, mechanism of action and pharmacokinetic characteristics, presenting numerous challenges during the clinical research phase. This paper mainly presents the clinical pharmacology study of six siRNA drugs, that have been approved by the U.S. Food and Drug Administration, from the pharmacokinetic characteristics, drug-drug interactions, the special population with liver or kidney dysfunction, immunogenicity and cardiac safety etc. By the comprehensive overview of the early clinical pharmacology evaluation method of siRNA drugs, we hope to provide references for the design of early clinical trials and the translation of clinical research of siRNA drugs.

, authors=Jiang-shuo LI^{1, 2}, Jian-xiong ZHANG^{1, 2}, Hang YIN^{1, 2}, Rui-hua DONG^{1, 2}, Jing-yi MA³, Shu-jie LIU³, Chun-min WEI³, Rui-rui HE³, authorsList=Jiang-shuo LI, Jian-xiong ZHANG, Hang YIN, Rui-hua DONG, Jing-yi MA, Shu-jie LIU, Chun-min WEI, Rui-rui HE, authorCompany=null, correspAuthors=Rui-rui HE, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404935191588957, articleId=1291404934633746523, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=关于小干扰RNA类药物临床药理学研究的考虑, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

小干扰RNA（siRNA）药物具有独特的分子结构、作用机制和药代动力学特征，在临床研究阶段面临较多挑战。本文主要结合美国食品药品监督管理局已批准上市的6款siRNA药物在临床药理学研究方面的新药研究实例，从药代动力学、药物-药物相互作用、肝肾功能不全的特殊人群、免疫原性和心脏安全性等方面综合概述了siRNA药物的早期临床药理评价方法，对siRNA药物的临床药理研究提出几点思考，以期为siRNA药物的早期临床试验设计及临床研究转化提供参考。

, authors=李江硕^{1, 2}, 张健雄^{1, 2}, 尹航^{1, 2}, 董瑞华^{1, 2}, 马婧怡³, 刘淑洁³, 魏春敏³, 贺锐锐³, authorsList=李江硕, 张健雄, 尹航, 董瑞华, 马婧怡, 刘淑洁, 魏春敏, 贺锐锐, authorCompany=null, correspAuthors=贺锐锐, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=CDyZ+7mrsXO3/B++Paz/vg==, magXml=EjytkoN63GdJYD75fokNwQ==, pdfUrl=null, pdf=Rr4nZAAFXomqVy7B7rSRTw==, pdfFileSize=1181117, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=jd8Aoiv8bBhdQwj+voXeFg==, mapNumber=null, fund=null)}, authors=[Author(id=1291404935850094696, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404935933980779, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404935850094696, language=EN, stringName=Jiang-shuo LI, firstName=Jiang-shuo, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.Department of Research Ward, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China
^2.Beijing Key Laboratory of Early Clinical Evaluation of Nucleic Acid Products and Cell Therapy, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404936051421292, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404935850094696, language=CN, stringName=李江硕, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.首都医科大学 附属北京友谊医院 研究型病房，北京 100050
^2.核酸类产品与细胞治疗早期临床评价北京市重点实验室，北京 100050, bio={"content":"

李江硕（1993-），女，主管药师，主要从事临床药理学方向研究

"}, bioImg=null, bioContent=

李江硕（1993-），女，主管药师，主要从事临床药理学方向研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404935430664286, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=1., ext=[AuthorCompanyExt(id=1291404935443247199, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935430664286, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Department of Research Ward, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China), AuthorCompanyExt(id=1291404935451635808, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935430664286, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.首都医科大学 附属北京友谊医院 研究型病房，北京 100050)]), AuthorCompany(id=1291404935514550369, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=2., ext=[AuthorCompanyExt(id=1291404935527133282, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935514550369, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Beijing Key Laboratory of Early Clinical Evaluation of Nucleic Acid Products and Cell Therapy, Beijing 100050, China), AuthorCompanyExt(id=1291404935531327587, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935514550369, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.核酸类产品与细胞治疗早期临床评价北京市重点实验室，北京 100050)])]), Author(id=1291404936126918766, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404936210804849, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404936126918766, language=EN, stringName=Jian-xiong ZHANG, firstName=Jian-xiong, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.Department of Research Ward, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China
^2.Beijing Key Laboratory of Early Clinical Evaluation of Nucleic Acid Products and Cell Therapy, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404936277913714, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404936126918766, language=CN, stringName=张健雄, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.首都医科大学 附属北京友谊医院 研究型病房，北京 100050
^2.核酸类产品与细胞治疗早期临床评价北京市重点实验室，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404935430664286, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=1., ext=[AuthorCompanyExt(id=1291404935443247199, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935430664286, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Department of Research Ward, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China), AuthorCompanyExt(id=1291404935451635808, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935430664286, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.首都医科大学 附属北京友谊医院 研究型病房，北京 100050)]), AuthorCompany(id=1291404935514550369, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=2., ext=[AuthorCompanyExt(id=1291404935527133282, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935514550369, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Beijing Key Laboratory of Early Clinical Evaluation of Nucleic Acid Products and Cell Therapy, Beijing 100050, China), AuthorCompanyExt(id=1291404935531327587, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935514550369, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.核酸类产品与细胞治疗早期临床评价北京市重点实验室，北京 100050)])]), Author(id=1291404936345022580, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404936433102967, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404936345022580, language=EN, stringName=Hang YIN, firstName=Hang, middleName=null, lastName=YIN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.Department of Research Ward, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China
^2.Beijing Key Laboratory of Early Clinical Evaluation of Nucleic Acid Products and Cell Therapy, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404936512794744, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404936345022580, language=CN, stringName=尹航, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.首都医科大学 附属北京友谊医院 研究型病房，北京 100050
^2.核酸类产品与细胞治疗早期临床评价北京市重点实验室，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404935430664286, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=1., ext=[AuthorCompanyExt(id=1291404935443247199, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935430664286, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Department of Research Ward, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China), AuthorCompanyExt(id=1291404935451635808, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935430664286, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.首都医科大学 附属北京友谊医院 研究型病房，北京 100050)]), AuthorCompany(id=1291404935514550369, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=2., ext=[AuthorCompanyExt(id=1291404935527133282, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935514550369, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Beijing Key Laboratory of Early Clinical Evaluation of Nucleic Acid Products and Cell Therapy, Beijing 100050, China), AuthorCompanyExt(id=1291404935531327587, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935514550369, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.核酸类产品与细胞治疗早期临床评价北京市重点实验室，北京 100050)])]), Author(id=1291404936571515002, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404936651206781, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404936571515002, language=EN, stringName=Rui-hua DONG, firstName=Rui-hua, middleName=null, lastName=DONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.Department of Research Ward, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China
^2.Beijing Key Laboratory of Early Clinical Evaluation of Nucleic Acid Products and Cell Therapy, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404936718315646, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404936571515002, language=CN, stringName=董瑞华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.首都医科大学 附属北京友谊医院 研究型病房，北京 100050
^2.核酸类产品与细胞治疗早期临床评价北京市重点实验室，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404935430664286, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=1., ext=[AuthorCompanyExt(id=1291404935443247199, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935430664286, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Department of Research Ward, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China), AuthorCompanyExt(id=1291404935451635808, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935430664286, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.首都医科大学 附属北京友谊医院 研究型病房，北京 100050)]), AuthorCompany(id=1291404935514550369, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=2., ext=[AuthorCompanyExt(id=1291404935527133282, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935514550369, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Beijing Key Laboratory of Early Clinical Evaluation of Nucleic Acid Products and Cell Therapy, Beijing 100050, China), AuthorCompanyExt(id=1291404935531327587, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935514550369, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.核酸类产品与细胞治疗早期临床评价北京市重点实验室，北京 100050)])]), Author(id=1291404936789618816, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404936860921986, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404936789618816, language=EN, stringName=Jing-yi MA, firstName=Jing-yi, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404936928030851, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404936789618816, language=CN, stringName=马婧怡, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.国家药品监督管理局 药品审评中心，北京 100022, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404935606825060, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=3., ext=[AuthorCompanyExt(id=1291404935615213669, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935606825060, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China), AuthorCompanyExt(id=1291404935623602278, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935606825060, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.国家药品监督管理局 药品审评中心，北京 100022)])]), Author(id=1291404936995139717, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404937070637191, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404936995139717, language=EN, stringName=Shu-jie LIU, firstName=Shu-jie, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404937137746056, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404936995139717, language=CN, stringName=刘淑洁, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.国家药品监督管理局 药品审评中心，北京 100022, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404935606825060, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=3., ext=[AuthorCompanyExt(id=1291404935615213669, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935606825060, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China), AuthorCompanyExt(id=1291404935623602278, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935606825060, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.国家药品监督管理局 药品审评中心，北京 100022)])]), Author(id=1291404937200660618, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404937288741004, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404937200660618, language=EN, stringName=Chun-min WEI, firstName=Chun-min, middleName=null, lastName=WEI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404937360044173, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404937200660618, language=CN, stringName=魏春敏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.国家药品监督管理局 药品审评中心，北京 100022, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404935606825060, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=3., ext=[AuthorCompanyExt(id=1291404935615213669, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935606825060, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China), AuthorCompanyExt(id=1291404935623602278, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935606825060, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.国家药品监督管理局 药品审评中心，北京 100022)])]), Author(id=1291404937435541647, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=herr@cde.org.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291404937515233425, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404937435541647, language=EN, stringName=Rui-rui HE, firstName=Rui-rui, middleName=null, lastName=HE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404937603313810, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, authorId=1291404937435541647, language=CN, stringName=贺锐锐, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.国家药品监督管理局 药品审评中心，北京 100022, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404935606825060, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=3., ext=[AuthorCompanyExt(id=1291404935615213669, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935606825060, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China), AuthorCompanyExt(id=1291404935623602278, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935606825060, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.国家药品监督管理局 药品审评中心，北京 100022)])])], keywords=[Keyword(id=1291404937695588499, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, language=EN, orderNo=1, keyword=small interference RNA), Keyword(id=1291404937775280276, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, language=EN, orderNo=2, keyword=N-acetylgalactosamine), Keyword(id=1291404937838194837, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, language=EN, orderNo=3, keyword=pharmacokinetics), Keyword(id=1291404937896915094, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, language=EN, orderNo=4, keyword=clinical pharmacology), Keyword(id=1291404937972412567, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, language=CN, orderNo=1, keyword=小干扰RNA), Keyword(id=1291404938043715736, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, language=CN, orderNo=2, keyword=N-乙酰半乳糖胺), Keyword(id=1291404938131796121, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, language=CN, orderNo=3, keyword=药代动力学), Keyword(id=1291404938207293594, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, language=CN, orderNo=4, keyword=临床药理)], refs=null, funds=[Fund(id=1291404938337317019, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, awardId=2024SKLDRS0231, language=CN, fundingSource=药品监管科学全国重点实验室第二批课题基金资助项目(2024SKLDRS0231), fundOrder=null, country=null), Fund(id=1291404938400231581, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, awardId=BHTPP2024090, language=CN, fundingSource=北京市卫生健康科技成果和适宜技术推广基金资助项目(BHTPP2024090), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1291404935430664286, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=1., ext=[AuthorCompanyExt(id=1291404935443247199, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935430664286, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Department of Research Ward, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China), AuthorCompanyExt(id=1291404935451635808, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935430664286, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.首都医科大学 附属北京友谊医院 研究型病房，北京 100050)]), AuthorCompany(id=1291404935514550369, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=2., ext=[AuthorCompanyExt(id=1291404935527133282, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935514550369, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Beijing Key Laboratory of Early Clinical Evaluation of Nucleic Acid Products and Cell Therapy, Beijing 100050, China), AuthorCompanyExt(id=1291404935531327587, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935514550369, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.核酸类产品与细胞治疗早期临床评价北京市重点实验室，北京 100050)]), AuthorCompany(id=1291404935606825060, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, xref=3., ext=[AuthorCompanyExt(id=1291404935615213669, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935606825060, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China), AuthorCompanyExt(id=1291404935623602278, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404934633746523, companyId=1291404935606825060, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.国家药品监督管理局 药品审评中心，北京 100022)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1784020014723, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1283836250926859016, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014745, updatedTime=1784020014745, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1283836250981384969, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014758, updatedTime=1784020014758, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.09.023, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.09.023, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.09.023, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.09.023, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1747411200000, fullTextJson=null, articleText=null, reference=null)