Article(id=1291405021824930275, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404875351449891, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.09.022, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1733760000000, receivedDateStr=2024-12-10, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824550347, onlineDateStr=2026-08-04, pubDate=1747411200000, pubDateStr=2025-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824550347, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824550347, creator=13701087609, updateTime=1785824550347, updator=13701087609, issue=Issue{id=1291404875351449891, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1747411200000', pubDateStr='2025-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824515426, creator='13701087609', updateTime=1785824515426, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1323, endPage=1328, ext={EN=ArticleExt(id=1291405022043034084, articleId=1291405021824930275, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status on the impact of endothelial cell dysfunction on blood supply in femoral head necrosis and the mechanisms of traditional Chinese medicine in promoting angiogenesis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Osteonrosis of the femoral head (ONFH) is an intractable orthopaedic disease caused by insufficient blood supply to the femoral head. As a highly vascularised tissue, vascular microcirculatory dysfunction can lead to increased apoptosis of bone cells and inadequate blood supply to the femoral head. Vascular endothelial cells are the main constituent cells of the vascular wall, which are crucial for maintaining the normal state of blood vessels, when inflammation, oxidative stress and other risk factors cause vascular endothelial cell dysfunction, it can disrupt vascular homeostasis and normal blood flow to the bone tissue, leading to inhibition of angiogenesis-osteogenesis coupling function, and ultimately resulting in necrosis due to insufficient osteogenesis and haematological transport to the femoral head. Traditional Chinese medicine can promote angiogenesis and reduce apoptosis of vascular endothelial cells by promoting the expression of vascular endothelial cytogenesis-related factors, and enhance the blood supply of the femoral head. Therefore, this article reviews the effects of vascular endothelial cell dysfunction on the blood supply of the femoral head and the mechanism of action of traditional Chinese medicine in promoting angiogenesis, with a view to providing ideas for the treatment of ONFH.

, authors=Zhen-hua SHI¹, Xiao-ping WANG^2a, Ming-wang ZHOU^2b, Hai-yuan GAO¹, Xian-jun ZHANG¹, authorsList=Zhen-hua SHI, Xiao-ping WANG, Ming-wang ZHOU, Hai-yuan GAO, Xian-jun ZHANG, authorCompany=null, correspAuthors=Ming-wang ZHOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291405022634430949, articleId=1291405021824930275, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=血管内皮细胞功能障碍对股骨头坏死血供的影响及中药促进血管生成的研究状况, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

股骨头坏死（ONFH）是股骨头血供不足导致的难治性骨科疾病。股骨头作为高度血管化的组织，血管微循环功能障碍可导致骨细胞凋亡增加、血供不足，从而诱发ONFH。血管内皮细胞作为血管壁的主要构成细胞，对维持血管的正常状态至关重要，当炎症、氧化应激等危险因素造成血管内皮细胞功能障碍时，可破坏血管稳态及正常的骨组织血流量，导致血管生成-成骨耦合功能被抑制，最终造成股骨头成骨不足、血运不畅而发生坏死。中药可通过促进血管内皮细胞生成相关因子的表达促进血管生成，减少血管内皮细胞的凋亡，增强股骨头血供。故本文通过综述血管内皮细胞功能障碍对股骨头血供的影响及中药促进血管生成作用机制的研究，以期为ONFH的治疗提供思路。

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史振华（1998-），男，硕士研究生，主要从事中医药防治骨与关节疾病的研究

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史振华（1998-），男，硕士研究生，主要从事中医药防治骨与关节疾病的研究

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