Article(id=1291405037780062832, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404875351449891, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.09.016, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1734278400000, receivedDateStr=2024-12-16, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824554151, onlineDateStr=2026-08-04, pubDate=1747411200000, pubDateStr=2025-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824554151, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824554151, creator=13701087609, updateTime=1785824554151, updator=13701087609, issue=Issue{id=1291404875351449891, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1747411200000', pubDateStr='2025-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824515426, creator='13701087609', updateTime=1785824515426, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1292, endPage=1298, ext={EN=ArticleExt(id=1291405037973000817, articleId=1291405037780062832, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research on the effects of Wuzi Yanzong pill intervention on testicular function injury in subacute aging rats based on metabolomics, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the effect of Wuzi Yanzong pill on testicular dysfunction in subacute aging rats through metabolomics.
Methods Forty-two rats were subcutaneously injected with 200 mg·kg-1 D-galactose (D-Gal) to induce a subacute aging model. After successful modeling, the rats were randomly divided into four groups: model group, control group, exprimental-L group, exprimental-H group, each with 9 rats. Eight normal rats without D-Gal treatment were used as the normal group. The exprimental-L,-H groups were administered Wuzi Yanzong pill at doses of 0.54 and 2.16 g·kg-1 by gavage, respectively, while the control group was given 300 mg·kg-1 metformin by gavage. The normal and model groups were treated with an equal volume of distilled water by gavage. All rats were dosed once daily for 4 weeks. During this period, the each group (except for the normal group) was continued injected 200 mg·kg-1 D-Gal injections. The levels of testosterone (T), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) in serum were measured using enzyme-linked immunosorbent assay (ELISA). The relative expression of proteins involved in testicular secretory function [hydroxysteroid 17-beta dehydrogenase 3 (HSD17B3), cytochrome P450, family 11, subfamily A, polypeptide 1 (CYP11A1), steroidogenic acute regulatory protein (STAR)] was determined by Western blot. Metabolomics analysis was performed to study metabolic changes in the testicular tissue.
Results The serum T levels in the normal, model, control, experimental-L, and experimental-H groups were (8.67±1.71), (1.95±0.46), (6.50±1.15), (2.45±0.49) and (5.81±0.96) pg·mL-1, respectively; the FSH levels were (28.53±4.16), (46.73±3.72), (30.18±5.17), (35.35±1.90) and (30.31±4.35) mU·mL-1, respectively; the LH levels were (22.66±3.97), (37.89±4.16), (24.28±3.75), (37.09±3.98) and (28.35±4.38) mU·mL-1, respectively; the relative protein expression levels of HSD17B3 were 1.04±0.05, 0.29±0.14, 0.78±0.18, 0.71±0.13 and 0.85±0.18; the relative protein expression levels of CYP11A1 were 1.23±0.15, 0.62±0.08, 1.01±0.05, 0.77±0.15 and 1.24±0.09; the relative protein expression levels of STAR were 0.97±0.12, 0.21±0.05, 0.79±0.19, 0.62±0.23 and 0.96±0.25, respectively. The model group showed significant differences in these indicators when compared with the control and experimental-H groups (all P<0.05). Metabolomics analysis identified six differential metabolites in the experimental-H group compared to the model group. These metabolites were mainly involved in steroid hormone biosynthesis, ovarian steroidogenesis, lipid metabolism, and biotin metabolism.
Conclusion In vivo and metabolomics studies show that Wuzi Yanzong pill improves antioxidant capacity in the testes, reduces oxidative stress damage, delays aging, and effectively treats testicular dysfunction, thereby improving testicular function.
, authors=Sheng MU
1a, 1b, Hui-ming MA
1c, Hong HUI
1a, Jing PU
1c, Wen-xin MA
1c, Chang LIU
1c, Zi-yu LIU
1c, Xiang-dong ZHU
1a, authorsList=Sheng MU, Hui-ming MA, Hong HUI, Jing PU, Wen-xin MA, Chang LIU, Zi-yu LIU, Xiang-dong ZHU, authorCompany=null, correspAuthors=Jing PU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291405038237241970, articleId=1291405037780062832, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于代谢组学的五子衍宗丸干预亚急性衰老大鼠睾丸功能损伤的作用研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 基于代谢组学探究五子衍宗丸干预亚急性衰老大鼠睾丸功能损伤的作用研究。
方法 42只大鼠颈部皮下注射200 mg·kg-1 D-半乳糖（D-Gal）诱导建立亚急性衰老模型大鼠，待造模成功后，随机分为模型组、对照组和低、高剂量实验组，每组9只，外取8只未造模的正常大鼠作为正常组。低、高剂量实验组分别按照0.54和2.16 g·kg-1的剂量灌胃给予五子衍宗丸，对照组按照300 mg·kg-1的剂量灌胃给予二甲双胍。正常组和模型组均灌胃给予等量蒸馏水，5组大鼠每天给药1次，连续4周；且在此期间除正常组外，其余各组均继续颈部皮下注射200 mg·kg-1 D-Gal。用酶联免疫吸附试验（ELISA）法检测血清中睾酮（T）、促卵泡激素（FSH）和黄体生成素（LH）的表达水平，用蛋白质印迹法检测睾丸组织中睾丸分泌功能相关蛋白[17β-羟基类固醇脱氢酶3型（HSD17B3）、细胞色素P450 11A1（CYP11A1）和类固醇急性调节蛋白（STAR）]的蛋白相对表达水平，用代谢组学研究睾丸组织中代谢成分。
结果 正常组、模型组、对照组和低、高剂量实验组的T水平分别为（8.67±1.71）、（1.95±0.46）、（6.50±1.15）、（2.45±0.49）和（5.81±0.96）pg·mL-1，FSH水平分别为（28.53±4.16）、（46.73±3.72）、（30.18±5.17）、（35.35±1.90）和（30.31±4.35）mU·mL-1，LH水平分别为（22.66±3.97）、（37.89±4.16）、（24.28±3.75）、（37.09±3.98）和（28.35±4.38）mU·mL-1，HSD17B3蛋白相对表达水平分别为1.04±0.05、0.29±0.14、0.78±0.18、0.71±0.13和0.85±0.18，CYP11A1蛋白相对表达水平分别为1.23±0.15、0.62±0.08、1.01±0.05、0.77±0.15和1.24±0.09，STAR蛋白相对表达水平分别为0.97±0.12、0.21±0.05、0.79±0.19、0.62±0.23和0.96±0.25。模型组的上述指标与对照组和高剂量实验组比较，在统计学上差异均有统计学意义（均P<0.05）。代谢组学结果显示，高剂量实验组与模型组相比，共有6个差异代谢物，主要通过类固醇激素生物合成、卵巢类固醇生成、脂质和类脂质分子和生物素代谢等代谢途径发挥作用。
结论 通过体内实验和代谢组学研究表明，五子衍宗丸能够提高睾丸抗氧化能力，降低其氧化应激损伤，延缓衰老，对睾丸功能损伤具有治疗作用，从而改善睾丸功能。
, authors=穆胜
1a, 1b, 马会明
1c, 惠宏
1a, 蒲静
1c, 马文欣
1c, 刘畅
1c, 刘自钰
1c, 朱向东
1a, authorsList=穆胜, 马会明, 惠宏, 蒲静, 马文欣, 刘畅, 刘自钰, 朱向东, authorCompany=null, correspAuthors=蒲静, authorNote=
穆胜（1996-），男，硕士研究生，主要从事中医药治疗男性生殖疾病研究
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=OTTBxt4TwKCz2ld53wN8yw==, magXml=nqyd8UD9Si4L8MLfPCts9w==, pdfUrl=null, pdf=h1fBJeat8G7MIVTC8dY/oQ==, pdfFileSize=1792265, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=a7gkm9f/UbCoOvql9lAvgA==, mapNumber=null, fund=null)}, authors=[Author(id=1291405038874776189, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291405038975439488, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405038874776189, language=EN, stringName=Sheng MU, firstName=Sheng, middleName=null, lastName=MU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1a, 1b, address=
1a.School of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China
1b.Key Laboratory of Modernization of Ethnic Minority Medicine in Ningxia, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291405039042548353, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405038874776189, language=CN, stringName=穆胜, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1a, 1b, address=
1a.宁夏医科大学，中医学院，宁夏回族自治区 银川 750000
1b.宁夏医科大学，宁夏少数民族医药现代化重点实验室，宁夏回族自治区 银川 750000, bio={"content":"
穆胜（1996-），男，硕士研究生，主要从事中医药治疗男性生殖疾病研究
"}, bioImg=null, bioContent=
穆胜（1996-），男，硕士研究生，主要从事中医药治疗男性生殖疾病研究
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291405038597952115, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, xref=1a., ext=[AuthorCompanyExt(id=1291405038606340724, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038597952115, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1a.School of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China), AuthorCompanyExt(id=1291405038614729333, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038597952115, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1a.宁夏医科大学，中医学院，宁夏回族自治区 银川 750000)]), AuthorCompany(id=1291405038677643894, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, xref=1b., ext=[AuthorCompanyExt(id=1291405038681838199, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038677643894, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1b.Key Laboratory of Modernization of Ethnic Minority Medicine in Ningxia, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China), AuthorCompanyExt(id=1291405038690226808, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038677643894, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1b.宁夏医科大学，宁夏少数民族医药现代化重点实验室，宁夏回族自治区 银川 750000)])]), Author(id=1291405039105462915, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291405039180960389, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405039105462915, language=EN, stringName=Hui-ming MA, firstName=Hui-ming, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1c, address=
1c.Key Laboratory of Fertility Preservation, Ministry of Education, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291405039243874950, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405039105462915, language=CN, stringName=马会明, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1c, address=
1c.宁夏医科大学，生育力保持教育部重点实验室，宁夏回族自治区 银川 750000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291405038757335673, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, xref=1c., ext=[AuthorCompanyExt(id=1291405038786695802, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038757335673, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1c.Key Laboratory of Fertility Preservation, Ministry of Education, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China), AuthorCompanyExt(id=1291405038799278715, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038757335673, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1c.宁夏医科大学，生育力保持教育部重点实验室，宁夏回族自治区 银川 750000)])]), Author(id=1291405039310983816, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291405039386481290, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405039310983816, language=EN, stringName=Hong HUI, firstName=Hong, middleName=null, lastName=HUI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1a, address=
1a.School of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291405039445201547, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405039310983816, language=CN, stringName=惠宏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1a, address=
1a.宁夏医科大学，中医学院，宁夏回族自治区 银川 750000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291405038597952115, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, xref=1a., ext=[AuthorCompanyExt(id=1291405038606340724, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038597952115, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1a.School of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China), AuthorCompanyExt(id=1291405038614729333, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038597952115, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1a.宁夏医科大学，中医学院，宁夏回族自治区 银川 750000)])]), Author(id=1291405039512310413, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=ajing313@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291405039592002191, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405039512310413, language=EN, stringName=Jing PU, firstName=Jing, middleName=null, lastName=PU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1c, address=
1c.Key Laboratory of Fertility Preservation, Ministry of Education, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291405039663305360, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405039512310413, language=CN, stringName=蒲静, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1c, address=
1c.宁夏医科大学，生育力保持教育部重点实验室，宁夏回族自治区 银川 750000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291405038757335673, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, xref=1c., ext=[AuthorCompanyExt(id=1291405038786695802, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038757335673, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1c.Key Laboratory of Fertility Preservation, Ministry of Education, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China), AuthorCompanyExt(id=1291405038799278715, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038757335673, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1c.宁夏医科大学，生育力保持教育部重点实验室，宁夏回族自治区 银川 750000)])]), Author(id=1291405039730414226, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291405039814300308, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405039730414226, language=EN, stringName=Wen-xin MA, firstName=Wen-xin, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1c, address=
1c.Key Laboratory of Fertility Preservation, Ministry of Education, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291405039881409173, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405039730414226, language=CN, stringName=马文欣, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1c, address=
1c.宁夏医科大学，生育力保持教育部重点实验室，宁夏回族自治区 银川 750000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291405038757335673, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, xref=1c., ext=[AuthorCompanyExt(id=1291405038786695802, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038757335673, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1c.Key Laboratory of Fertility Preservation, Ministry of Education, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China), AuthorCompanyExt(id=1291405038799278715, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038757335673, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1c.宁夏医科大学，生育力保持教育部重点实验室，宁夏回族自治区 银川 750000)])]), Author(id=1291405039952712343, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291405040032404121, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405039952712343, language=EN, stringName=Chang LIU, firstName=Chang, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1c, address=
1c.Key Laboratory of Fertility Preservation, Ministry of Education, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291405040091124378, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405039952712343, language=CN, stringName=刘畅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1c, address=
1c.宁夏医科大学，生育力保持教育部重点实验室，宁夏回族自治区 银川 750000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291405038757335673, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, xref=1c., ext=[AuthorCompanyExt(id=1291405038786695802, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038757335673, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1c.Key Laboratory of Fertility Preservation, Ministry of Education, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China), AuthorCompanyExt(id=1291405038799278715, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038757335673, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1c.宁夏医科大学，生育力保持教育部重点实验室，宁夏回族自治区 银川 750000)])]), Author(id=1291405041743680156, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291405041844343454, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405041743680156, language=EN, stringName=Zi-yu LIU, firstName=Zi-yu, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1c, address=
1c.Key Laboratory of Fertility Preservation, Ministry of Education, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291405041907258015, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405041743680156, language=CN, stringName=刘自钰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1c, address=
1c.宁夏医科大学，生育力保持教育部重点实验室，宁夏回族自治区 银川 750000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291405038757335673, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, xref=1c., ext=[AuthorCompanyExt(id=1291405038786695802, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038757335673, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1c.Key Laboratory of Fertility Preservation, Ministry of Education, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China), AuthorCompanyExt(id=1291405038799278715, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038757335673, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1c.宁夏医科大学，生育力保持教育部重点实验室，宁夏回族自治区 银川 750000)])]), Author(id=1291405041974366881, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291405042070835875, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405041974366881, language=EN, stringName=Xiang-dong ZHU, firstName=Xiang-dong, middleName=null, lastName=ZHU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1a, address=
1a.School of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291405042142139044, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, authorId=1291405041974366881, language=CN, stringName=朱向东, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1a, address=
1a.宁夏医科大学，中医学院，宁夏回族自治区 银川 750000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291405038597952115, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, xref=1a., ext=[AuthorCompanyExt(id=1291405038606340724, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038597952115, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1a.School of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China), AuthorCompanyExt(id=1291405038614729333, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038597952115, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1a.宁夏医科大学，中医学院，宁夏回族自治区 银川 750000)])])], keywords=[Keyword(id=1291405042242802341, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, language=EN, orderNo=1, keyword=Wuzi Yanzong pill), Keyword(id=1291405042314105510, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, language=EN, orderNo=2, keyword=subacute aging rats), Keyword(id=1291405042393797287, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, language=EN, orderNo=3, keyword=testicular dysfunction), Keyword(id=1291405042494460584, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, language=EN, orderNo=4, keyword=metabolomics), Keyword(id=1291405042603512489, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, language=EN, orderNo=5, keyword=oxidative stress), Keyword(id=1291405042720953002, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, language=CN, orderNo=1, keyword=五子衍宗丸), Keyword(id=1291405042830004907, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, language=CN, orderNo=2, keyword=亚急性衰老大鼠), Keyword(id=1291405042934862508, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, language=CN, orderNo=3, keyword=睾丸功能损伤), Keyword(id=1291405043064885933, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, language=CN, orderNo=4, keyword=代谢组学), Keyword(id=1291405043182326446, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, language=CN, orderNo=5, keyword=氧化应激)], refs=null, funds=[Fund(id=1291405043379458735, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, awardId=82274624, language=CN, fundingSource=国家自然科学基金资助项目(82274624), fundOrder=null, country=null), Fund(id=1291405043467539120, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, awardId=2023AAC03211, language=CN, fundingSource=宁夏自然科学基金资助项目(2023AAC03211), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1291405038597952115, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, xref=1a., ext=[AuthorCompanyExt(id=1291405038606340724, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038597952115, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1a.School of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China), AuthorCompanyExt(id=1291405038614729333, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038597952115, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1a.宁夏医科大学，中医学院，宁夏回族自治区 银川 750000)]), AuthorCompany(id=1291405038677643894, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, xref=1b., ext=[AuthorCompanyExt(id=1291405038681838199, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038677643894, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1b.Key Laboratory of Modernization of Ethnic Minority Medicine in Ningxia, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China), AuthorCompanyExt(id=1291405038690226808, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038677643894, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1b.宁夏医科大学，宁夏少数民族医药现代化重点实验室，宁夏回族自治区 银川 750000)]), AuthorCompany(id=1291405038757335673, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, xref=1c., ext=[AuthorCompanyExt(id=1291405038786695802, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038757335673, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1c.Key Laboratory of Fertility Preservation, Ministry of Education, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China), AuthorCompanyExt(id=1291405038799278715, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291405037780062832, companyId=1291405038757335673, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1c.宁夏医科大学，生育力保持教育部重点实验室，宁夏回族自治区 银川 750000)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1784020014723, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1283836250926859016, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014745, updatedTime=1784020014745, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1283836250981384969, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014758, updatedTime=1784020014758, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.09.016, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.09.016, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.09.016, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.09.016, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1747411200000, fullTextJson=null, articleText=null, reference=null)
PDF下载
全屏
5
2
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
