Article(id=1291405016020013499, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404875351449891, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.09.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1732896000000, receivedDateStr=2024-11-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824548964, onlineDateStr=2026-08-04, pubDate=1747411200000, pubDateStr=2025-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824548964, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824548964, creator=13701087609, updateTime=1785824548964, updator=13701087609, issue=Issue{id=1291404875351449891, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1747411200000', pubDateStr='2025-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824515426, creator='13701087609', updateTime=1785824515426, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1261, endPage=1267, ext={EN=ArticleExt(id=1291405016347169212, articleId=1291405016020013499, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research of paeoniflorin reducing insulin resistance and myocardial damage in gestational diabetes rats, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effects of paeoniflorin on insulin resistance and myocardial injury in rats with gestational diabetes mellitus and its mechanism.
Methods Female rats were randomly divided into control group (normal diet), model group [male rats fed with high-fat diet and intraperitoneally injected 30 mg·kg-1 streptozotocin (STZ) after close cages], experimental group (after modeling, 50 mg·kg-1 paeoniflorin was given by gavage), si-NC group (50 mg·kg-1 paeoniflorin + si-NC plasmid injected into tail vein after modeling), si-IGFBP2 group (50 mg·kg-1 paeoniflorin + si-IGFBP2 plasmid injected into tail vein after modeling), each group of 10 rats. After 2 weeks of continuous treatment, fasting blood glucose (FBG) was measured with a glucose meter. Serum insulin-like growth factor binding protein 2 (IGFBP2), fasting insulin (FINS), cardiac troponin Ⅰ (cTnⅠ), creatine kinase isoenzyme MB (CK-MB) related factors were detected by enzyme-linked immunosorbent assay (ELISA), insulin resistance index (HOMA-IRI) was calculated, and the expression of signal pathway-related proteins was detected by Western blot assay.
Results The levels of FBG in control group, model group, experimental group, si-NC group and si-IGFBP2 group were: (5.62±0.56), (18.10±1.76), (9.81±1.46), (10.02±1.38) and (16.32±1.87) mmol·L-1, respectively; IGFBP2 levels were (39.47±2.64), (20.65±1.86), (27.18±1.85), (27.95±1.74) and (15.28±1.22) ng·mL-1, respectively; FINS levels were (8.72±0.75), (21.11±2.50), (16.88±1.86), (16.06±1.39) and (20.01±2.94) mU·L-1, respectively; cTnⅠ levels were (406.04±29.98), (788.11±84.43), (513.70±57.62), (526.85±38.03) and (756.51±63.88) pg·mL-1, respectively; CK-MB levels were (7.98±0.07), (15.15±1.26), (11.59±1.23), (11.37±1.79) and (13.49±1.54) U·L-1, respectively; HOMA-IRI levels were 2.17±0.26, 16.92±2.12, 6.24±0.95, 6.60±1.10 and 12.83±1.68, respectively; the relative expression levels of phosphorylate-phosphatidylinositol 3-kinase (p-PI3K) protein were 0.68±0.11, 0.39±0.04, 0.53±0.05, 0.51±0.06 and 0.43±0.04, respectively; the above indexes in the model group were compared with the control group, the experimental group were compared with the model group, and the si-IGFBP2 group were compared with the si-NC group, the differences were statistically significant (all P<0.05).
Conclusion Paeoniflorin may improve insulin resistance and myocardium injury in gestational diabetes mellitus rats by up-regulating IGFBP2 expression.
, authors=Jian-ying XIAO
1, Jun-jiang ZHU
2, Gui-hong KANG
1, Jin-fen LI
1, authorsList=Jian-ying XIAO, Jun-jiang ZHU, Gui-hong KANG, Jin-fen LI, authorCompany=null, correspAuthors=Jin-fen LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291405016661742013, articleId=1291405016020013499, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=芍药苷减轻妊娠期糖尿病大鼠胰岛素抵抗和心肌损伤的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨芍药苷对妊娠期糖尿病大鼠胰岛素抵抗和心肌损伤的影响及其作用机制。
方法 将雌性大鼠随机分为对照组（普通饲料）、模型组[高脂饲料喂养+腹腔注射30 mg·kg-1链脲佐菌素（STZ）]、实验组（建模后灌胃给予50 mg·kg-1的芍药苷）、si-NC组（建模后灌胃给予50 mg·kg-1的芍药苷+尾静脉注射si-NC质粒）和si-IGFBP2组（建模后灌胃给予50 mg·kg-1的芍药苷+尾静脉注射si-IGFBP2质粒），每组10只，连续治疗2周。用血糖仪测定空腹血糖（FBG），用酶联免疫吸附试验（ELISA）法检测血清胰岛素样生长因子结合蛋白2（IGFBP2）、空腹胰岛素（FINS）、心肌肌钙蛋白Ⅰ（cTnⅠ）和肌酸激酶同工酶MB（CK-MB）相关因子表达水平，并计算胰岛素抵抗指数（HOMA-IRI），用蛋白质印迹实验检测信号通路相关蛋白表达水平。
结果 对照组、模型组、实验组、si-NC组和si-IGFBP2组的FBG水平分别为（5.62±0.56）、（18.10±1.76）、（9.81±1.46）、（10.02±1.38）和（16.32±1.87）mmol·L-1，IGFBP2水平分别为（39.47±2.64）、（20.65±1.86）、（27.18±1.85）、（27.95±1.74）和（15.28±1.22）ng·mL-1，FINS水平分别为（8.72±0.75）、（21.11±2.50）、（16.88±1.86）、（16.06±1.39）和（20.01±2.94）mU·L-1，cTnⅠ水平分别为（406.04±29.98）、（788.11±84.43）、（513.70±57.62）、（526.85±38.03）和（756.51±63.88）pg·mL-1，CK-MB水平分别为（7.98±0.07）、（15.15±1.26）、（11.59±1.23）、（11.37±1.79）和（13.49±1.54）U·L-1，HOMA-IRI水平分别为2.17±0.26、16.92±2.12、6.24±0.95、6.60±1.10和12.83±1.68，磷酸化-磷脂酰肌醇3-激酶（p-PI3K）蛋白相对表达水平分别为0.68±0.11、0.39±0.04、0.53±0.05、0.51±0.06和0.43±0.04，模型组的上述指标与对照组比较，实验组的上述指标与模型组比较，si-IGFBP2组的上述指标与si-NC组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 芍药苷可能通过上调IGFBP2表达改善妊娠期糖尿病大鼠胰岛素抵抗和妊娠期糖尿病相关心肌损伤。
, authors=肖建英
1, 朱俊江
2, 康桂红
1, 李金芬
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肖建英（1979-），女，副主任医师，主要从事妊娠期高血糖疾病方面的临床诊疗工作
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