Article(id=1291404901398082302, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.08.024, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1735315200000, receivedDateStr=2024-12-28, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824521636, onlineDateStr=2026-08-04, pubDate=1745769600000, pubDateStr=2025-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824521636, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824521636, creator=13701087609, updateTime=1785824521636, updator=13701087609, issue=Issue{id=1291404807152067353, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1745769600000', pubDateStr='2025-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824499166, creator='13701087609', updateTime=1785897109470, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291709356903522905, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291709356903522906, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1186, endPage=1190, ext={EN=ArticleExt(id=1291404901628769023, articleId=1291404901398082302, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of clinical and mechanistic on butylphthalide for Parkinson’s disease, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Parkinson’s disease (PD), a highly disabling neurodegenerative disorder, poses significant clinical challenges in both prevention and therapeutic intervention. Butylphthalide (NBP), a small-molecule compound derived from celery seeds, has garnered considerable attention due to its remarkable neuroprotective properties. This article systematically reviews recent studies, demonstrating that NBP not only ameliorates motor and non-motor symptoms in PD patients but also slows disease progression through modulation of neuroinflammation and mitochondrial function. By integrating clinical evidence with advances in molecular mechanism research, it provides a scientific foundation for in-depth investigation of NBP-based PD management and development of novel therapeutics.

, authors=Miao YU^{1, 2}, Chong-yang ZHANG^{1, 2}, Xiao SUN², Yun LUO², Zun-peng SHU^{1, 3}, Xiao-bo SUN², Yan-fen CHEN¹, authorsList=Miao YU, Chong-yang ZHANG, Xiao SUN, Yun LUO, Zun-peng SHU, Xiao-bo SUN, Yan-fen CHEN, authorCompany=null, correspAuthors=Yan-fen CHEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404901993673472, articleId=1291404901398082302, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=丁苯酞在帕金森病中的临床研究与作用机制现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

帕金森病（PD）是一种高致残率的神经退行性疾病，其防治面临重大临床挑战。丁苯酞（NBP）是从芹菜籽中提取的小分子化合物，因其显著的神经保护作用备受关注。本文系统梳理近年研究，揭示NBP不仅能显著改善PD患者运动及非运动症状，还可通过调控神经炎症、线粒体功能等途径延缓疾病进展。通过整合其临床研究证据与分子机制研究现状，为NBP防治PD的深入研究及PD治疗药物的研发提供科学依据。

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于淼（2000-），男，硕士研究生，主要从事中药药理学方面的研究

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于淼（2000-），男，硕士研究生，主要从事中药药理学方面的研究

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