Article(id=1291404859866079407, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.08.020, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1731513600000, receivedDateStr=2024-11-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824511733, onlineDateStr=2026-08-04, pubDate=1745769600000, pubDateStr=2025-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824511733, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824511733, creator=13701087609, updateTime=1785824511733, updator=13701087609, issue=Issue{id=1291404807152067353, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1745769600000', pubDateStr='2025-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824499166, creator='13701087609', updateTime=1785897109470, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291709356903522905, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291709356903522906, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1164, endPage=1169, ext={EN=ArticleExt(id=1291404861040484528, articleId=1291404859866079407, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Evaluation of SGLT-2 inhibitors for type 2 diabetes mellitus treatment effectiveness, columnId=1246531413395263850, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Research Method, runingTitle=null, highlight=null, articleAbstract=
Objective To establish a pharmacodynamic model of sodium-glucose transporter 2 inhibitors (SGLT-2i) in order to evaluate the efficacy characteristics of the drugs.
Methods A model-based meta-analysis was used. By searching randomized controlled trials of SGLT-2i monotherapy in patients with type 2 diabetes (T2DM) in databases, the change in glycosylated hemoglobin (HbA1c) from baseline was used as the efficacy indicator. The pharmacodynamic models of SGLT-2i and placebo were constructed, and the covariates were screened to determine the factors affecting the drug’s efficacy.
Results A total of 39 studies were included, involving 96 trial groups, 8 534 participants, and 13 drugs (dapagliflozin, canagliflozin, empagliflozin, ipragliflozin, luseogliflozin, ertuglilfozin, enavogliflozin, henagliflozin, licogliflozin, sotagliflozin, bexagliflozin, janagliflozin and tofogliflozin). The time-effect relationships of the drug group and the placebo group were consistent with the Emax model, and fasting plasma glucose baseline had an effect on the pharmacodynamic parameters of SGLT-2i.
Conclusion The final model can describe the pharmacodynamic characteristics of the drug and placebo groups, and there is a significant association between FPB baseline and drug efficacy.
, authors=Xin-yi MA, Pan-pan XIE, Zhi-xing CHEN, Xi WENG, Ai-xin SHI, authorsList=Xin-yi MA, Pan-pan XIE, Zhi-xing CHEN, Xi WENG, Ai-xin SHI, authorCompany=null, correspAuthors=Ai-xin SHI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404861585744049, articleId=1291404859866079407, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=SGLT-2抑制药治疗2型糖尿病的有效性分析, columnId=1246531413600784769, journalTitle=中国临床药理学杂志, columnName=研究方法, runingTitle=null, highlight=null, articleAbstract=
目的 建立钠-葡萄糖协同转运蛋白-2抑制药（SGLT-2i）药效学模型，定量评估药物的疗效特征。
方法 基于模型的荟萃分析（MBMA）的方法，在公共数据库中检索SGLT-2i单药治疗2型糖尿病（T2DM）患者的随机对照试验。以糖化血红蛋白（HbA1c）较基线的变化值作为疗效指标，构建SGLT-2i和安慰剂的药效学模型，并进行协变量筛选，确定药效的影响因素。
结果 共纳入39篇文献，包含96个试验组，8 534例受试者，13种药物（达格列净、卡格列净、恩格列净、伊格列净、鲁格列净、依那格列净、贝格列净、埃格列净、加格列净、利格列净、索格列净、托格列净、恒格列净）。药物组和安慰剂组的时间效应关系均符合Emax模型，并发现空腹血糖基线值（FPG baseline）对SGLT-2i的药效有重要影响。
结论 最终模型可以描述药物组和安慰剂组的药效学特征，且FPB baseline与药物疗效之间存在显著关联。
, authors=马昕怡, 谢潘潘, 陈志兴, 翁茜, 史爱欣, authorsList=马昕怡, 谢潘潘, 陈志兴, 翁茜, 史爱欣, authorCompany=null, correspAuthors=史爱欣, authorNote=
马昕怡（2000-），女，硕士研究生，主要从事临床药学的相关研究
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