Article(id=1291404866216260052, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.08.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729094400000, receivedDateStr=2024-10-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824513248, onlineDateStr=2026-08-04, pubDate=1745769600000, pubDateStr=2025-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824513248, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824513248, creator=13701087609, updateTime=1785824513248, updator=13701087609, issue=Issue{id=1291404807152067353, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1745769600000', pubDateStr='2025-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824499166, creator='13701087609', updateTime=1785824499166, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1114, endPage=1118, ext={EN=ArticleExt(id=1291404866639884757, articleId=1291404866216260052, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Protective effects of resveratrol on kidney of diabetic rats based on lipid metabolism pathway, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the protective effect of resveratrol on kidney of diabetic rats through lipid metabolism pathway.
Methods The SD rats were randomly divided into control group, model group and experimental -L, -M, -H groups. The control group was fed with normal feed, while the other four groups were all based on high-fat and high-sugar feed feeding + intraperitoneal injection of streptozotocin to establish diabetic rat models. After successful modeling, the control group and the model group were given the same amount of normal saline, while the experimental-L, -M, -H groups were given 5, 25, 50 mg·kg-1 concentration of resveratrol once a day, and were given continuous gavage for 10 weeks. Kidney function levels [cystatin C (Cys-C), serum creatinine (SCr), blood urea nitrogen (BUN)]were determined by enzyme-linked immunosorbent assay. The expressions of peroxissome proliferator-activated receptor γ (PPARγ), fatty acid- binding protein (FABP1), peroxisomal acyl-coenzyme A oxidase 1 (ACOX) 2 and ACOX1 were detected by Western blot.
Results The Cys-C levels of experimental -M, -H groups, control group, model group were (1.85±0.15), (1.39±0.11), (0.78±0.11) and (2.42±0.32) mg·L-1; SCr levels were (55.74±7.02), (48.15±6.97), (32.41±4.22) and (68.15±8.48) μmol·L-1; BUN levels were (10.37±1.02), (9.41±0.87), (7.12±1.12) and (14.48±2.45) mmol·L-1; the relative expression levels of PPARγ protein were 0.74±0.08, 0.92±0.10, 1.22±0.15 and 0.39±0.05; the relative expression levels of FABP1 protein were 0.64±0.08, 0.81±0.07, 0.98±0.09 and 0.30±0.05; the relative expression levels of ACOX2 protein were 0.59±0.06, 0.72±0.07, 0.85±0.13 and 0.27±0.05; the relative expression levels of ACOX1 protein were 0.58±0.06, 0.67±0.05, 0.78±0.06 and 0.24±0.03. The differences of above indexes were statistically significant between the experimental-M, -H groups and control group and the model group (all P<0.05).
Conclusion Resveratrol may play a protective role on kidney of diabetic rats by regulating lipid metabolism pathway.
, authors=Hui-na ZHANG, Min YU, Wei GU, Li-ping HOU, Li-rong CHENG, authorsList=Hui-na ZHANG, Min YU, Wei GU, Li-ping HOU, Li-rong CHENG, authorCompany=null, correspAuthors=Wei GU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404868409881047, articleId=1291404866216260052, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于脂代谢通路探索白藜芦醇对糖尿病大鼠肾的保护作用, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探索白藜芦醇通过脂代谢通路对糖尿病大鼠肾的保护作用，及其作用机制。
方法 将SD大鼠随机分为对照组、模型组和低、中、高剂量实验组，每组10只。对照组给予普通饲料喂养，其余4组均基于高脂高糖饲料喂养+腹腔注射链脲佐菌素构建糖尿病大鼠模型。造模成功后，对照组和模型组均灌胃给予等量0.9% NaCl；低、中、高剂量实验组分别灌胃给予5、25、50 mg·kg-1白藜芦醇。5组大鼠每天给药1次，连续灌胃10周。用酶联免疫吸附试验法测定肾功能水平[胱抑素C（Cys-C）、血清肌酸酐（SCr）、血尿素氮（BUN）]，用蛋白质印迹法检测肾组织中过氧化物酶体增殖物激活受体γ（PPARγ）、脂肪酸结合蛋白（FABP1）、酰基辅酶A氧化酶（ACOX）2和ACOX1蛋白的表达情况。
结果 中、高剂量实验组和对照组、模型组的Cys-C水平分别为（1.85±0.15）、（1.39±0.11）、（0.78±0.11）和（2.42±0.32）mg·L-1，SCr水平分别为（55.74±7.02）、（48.15±6.97）、（32.41±4.22）和（68.15±8.48）μmol·L-1，BUN水平分别为（10.37±1.02）、（9.41±0.87）、（7.12±1.12）和（14.48±2.45）mmol·L-1，PPARγ蛋白相对表达水平分别为0.74±0.08、0.92±0.10、1.22±0.15和0.39±0.05，FABP1蛋白相对表达水平分别为0.64±0.08、0.81±0.07、0.98±0.09和0.30±0.05，ACOX2蛋白相对表达水平分别为0.59±0.06、0.72±0.07、0.85±0.13和0.27±0.05，ACOX1蛋白相对表达水平分别为0.58±0.06、0.67±0.05、0.78±0.06和0.24±0.03。中、高剂量实验组和对照组的上述指标与模型组相比，在统计学上差异均有统计学意义（均P<0.05）。
结论 白藜芦醇可能通过调节脂代谢通路对糖尿病大鼠发挥肾保护作用。
, authors=张惠娜, 于敏, 谷巍, 侯丽萍, 程黎蓉, authorsList=张惠娜, 于敏, 谷巍, 侯丽萍, 程黎蓉, authorCompany=null, correspAuthors=谷巍, authorNote=
张惠娜（1981-），女，主治医师，主要从事脂代谢与糖尿病肾病的相关研究和临床诊疗工作
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张惠娜（1981-），女，主治医师，主要从事脂代谢与糖尿病肾病的相关研究和临床诊疗工作
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